Category: 67085-11-4

Related Products of 67085-11-4,Some common heterocyclic compound, 67085-11-4, name is 4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol, molecular formula is C13H15ClN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Take 5kg of 1-(2-hydroxy-4-(4-chlorophenyl)butyl)-1-hydro-imidazole,Fully dissolved in 35 kg of methylene chloride and added at a rate of 1.5 ml/s at 20C5kg of thionyl chloride was slowly warmed to 32C and the reaction was incubated for 1 hour.Then reflux at 60 C for 1 hour, slowly cooled to 15 C to obtain the reaction solution;In the reaction solution, 10 C. water was added at a rate of 0.5 ml/s with stirring, the volume ratio of the reaction solution to water was 0.005:1, and anhydrous sodium carbonate was added at 1.0-1.5 kg/L. Suction filtrationSolid, the liquid was concentrated at 55 C until the dichloromethane evaporated, and dried.This yields 1-(2-chloro-4-(4-chlorophenyl)butyl)-1H-imidazole with a purity of 99.17%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol, its application will become more common.

Reference:
Patent; Zhuzhou Qianjin Pharmaceutical Co., Ltd.; Li Sanxin; Peng Kaifeng; Ling Yonggen; Wen Fengqiu; Gong Yun; Li Fujun; (13 pag.)CN105198818; (2018); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67085-11-4, name is 4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C13H15ClN2O

(1) 5 kg of 1-(2-hydroxy-4-(4-chlorophenyl)butyl)-1H-imidazole, fully dissolved in 35 kg of methylene chloride,5kg of thionyl chloride was added dropwise at a rate of 1.5ml/s at 20C, and the temperature was slowly raised to 32C and the reaction was incubated for 1 hour.Then reflux at 60 C for 1 hour, slowly cooled to 15 C to obtain the reaction solution;(2) In the reaction solution obtained in step (1), add 10C water at a rate of 0.5 ml/s while stirring.The volume ratio of liquid to water is 0.005:1, and then anhydrous sodium carbonate is added at 1.3 kg/L, suction filtration,The solid was discarded, and the liquid was concentrated at 55 C until no dichloromethane was distilled off.Dry, that is, too. Upon detection, the yield of the product of this example was 99.18%.The target product and impurity levels were determined using HPLC and standards. After testing,The target product, 1-(2-chloro-4-(4-chlorophenyl)butyl)-1H-imidazole, has a content of 99.17%.

According to the analysis of related databases, 67085-11-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zhuzhou Qianjin Pharmaceutical Co., Ltd.; Li Fujun; Bai Lu; Peng Kaifeng; Wen Fengqiu; Li Sanxin; Gong Yun; (10 pag.)CN105198814; (2018); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67085-11-4, name is 4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C13H15ClN2O

(1) 5 kg of 1-(2-hydroxy-4-(4-chlorophenyl)butyl)-1H-imidazole, fully dissolved in 35 kg of methylene chloride,5kg of thionyl chloride was added dropwise at a rate of 1.5ml/s at 20C, and the temperature was slowly raised to 32C and the reaction was incubated for 1 hour.Then reflux at 60 C for 1 hour, slowly cooled to 15 C to obtain the reaction solution;(2) In the reaction solution obtained in step (1), add 10C water at a rate of 0.5 ml/s while stirring.The volume ratio of liquid to water is 0.005:1, and then anhydrous sodium carbonate is added at 1.3 kg/L, suction filtration,The solid was discarded, and the liquid was concentrated at 55 C until no dichloromethane was distilled off.Dry, that is, too. Upon detection, the yield of the product of this example was 99.18%.The target product and impurity levels were determined using HPLC and standards. After testing,The target product, 1-(2-chloro-4-(4-chlorophenyl)butyl)-1H-imidazole, has a content of 99.17%.

According to the analysis of related databases, 67085-11-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zhuzhou Qianjin Pharmaceutical Co., Ltd.; Li Fujun; Bai Lu; Peng Kaifeng; Wen Fengqiu; Li Sanxin; Gong Yun; (10 pag.)CN105198814; (2018); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 67085-11-4,Some common heterocyclic compound, 67085-11-4, name is 4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol, molecular formula is C13H15ClN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

B. Alternatively, a mixture of 1-(4-(4-chlorophenyl)-2-hydroxybutyl)imidazole (1.8 kg, 7.18 mol), 2.25 equivalents of pyridine-sulfur trioxide complex and methylene chloride (8.6 L) stirred in the presence of excess dimethyl sulfoxide (19 L) and triethylamine (9 L) at 20-35 C. for 3 hours. Upon completion of reaction, the mixture was combined with water (76 L) and hexane (34.4 L). The product was isolated, washed with water and hexane and dried to yield 4-(4-chlorophenyl)-1-(imidazol-1-yl)butan-2-one, 1.48 kg (83% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol, its application will become more common.

Reference:
Patent; Syntex (U.S.A.) Inc.; US5208331; (1993); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 67085-11-4, name is 4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 67085-11-4

(1) 3 kg of 1-(2-hydroxy-4-(4-chlorophenyl)butyl)-1-hydro-imidazole was dissolved in 30 kg of methylene chloride.3.5 kg of thionyl chloride was added dropwise at a rate of 1.5 ml/s at 20C and slowly warmed to 33C.The reaction was incubated for 1 hour, then refluxed at 60C for 1 hour, and slowly cooled to below 15C to obtain a reaction liquid;(2) In the reaction liquid obtained in step (1), add 10 C. water at a rate of 0.5 ml/s with stirring, and the volume ratio of the reaction liquid to water is 0.005:1, and then 1.0 to 1.5 kg/L. Add anhydrous sodium carbonate, suction filter, discard the solid,The liquid was concentrated at 55[deg.] C. until no dichloromethane was distilled off, dried and obtained.Upon detection, the yield of the product of this example was 99.18%. The target product and impurity levels were determined using HPLC and standards.The target product, 1-(2-chloro-4-(4-chlorophenyl)butyl)-1H-imidazole, was detected to be 99.17%.The content of 1-(1-chloro-4-(4-chlorophenyl)butan-2-yl)-1-hydro-imidazole is 0.53%.The 1-(2-hydroxy-4-(4-chlorophenyl)butyl)-1H-imidazole content was 0.12%.

The synthetic route of 67085-11-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhuzhou Qianjin Pharmaceutical Co., Ltd.; Peng Kaifeng; Zhang Yingshuai; Wen Fengqiu; Li Sanxin; Gong Yun; Li Fujun; (10 pag.)CN105175338; (2018); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 67085-11-4, A common heterocyclic compound, 67085-11-4, name is 4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol, molecular formula is C13H15ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

PREPARATION 7 A mixture of 1-[4-(4-chlorophenyl)-2-hydroxy-n-butyl]imidazole (20 g) in dry pyridine (100 ml) was cooled in an ice bath and treated dropwise with stirring with 7.0 ml of methanesulfonyl chloride. The mixture was allowed to come to room temperature overnight and diluted to 500 ml by the addition of ethyl acetate, with stirring. The resulting solid was then filtered off, washed with acetone and dried in air to give 1-[4-(4-chlorophenyl)-2-(methanesulfonyloxy)-n-butyl]imidazole hydrochloride as a white solid (27.4 g).

The synthetic route of 67085-11-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Syntex (U.S.A.) Inc.; US4518607; (1985); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 67085-11-4, name is 4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol, A new synthetic method of this compound is introduced below., category: imidazoles-derivatives

PREPARATION 5 1-[2-Hydroxy-4-(4-chlorophenyl)-n-butyl]imidazole (2.0 g) in thionyl chloride (10 ml) is warmed for one hour at 65. The excess thionyl chloride is removed in vacuo, the residue dissolved in dichloromethane (75 ml) and shaken with excess aqueous potassium carbonate. The organic layer is washed with water, dried over MgSO4, evaporated and the residue evacuated to remove all traces of dichloromethane, affording 1-[2-chloro-4-(4-chlorophenyl)-n-butyl]imidazole.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Syntex (U.S.A.) Inc.; US4272545; (1981); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

67085-11-4, These common heterocyclic compound, 67085-11-4, name is 4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Take 5kg of 1-(2-hydroxy-4-(4-chlorophenyl)butyl)-1H-imidazole and dissolve it sufficiently in 35kg of methylene chloride. 5kg of thionyl chloride was added dropwise at a rate of 1.5ml/s at 20C, and the temperature was slowly raised to 32C and the reaction was incubated for 1 hour. Then reflux at 60 C for 1 hour, slowly cooled to 15 C to obtain the reaction solution; In the reaction solution, 10 C. water was added at a rate of 0.5 ml/s with stirring, and the volume ratio of the reaction solution to water was 0.005:1. Anhydrous sodium carbonate was further added at 1.0 to 1.5 kg/L. After suction filtration, the solid was discarded, the liquid was concentrated at 55 C. until no dichloromethane was distilled off, and dried to obtain 1-(2-chloro-4-(4-chlorophenyl)butyl)-1-hydro-imidazole. The purity is 99.17%. The 1-(2-chloro-4-(4-chlorophenyl)butyl)-1H-imidazole was used as a raw material in Examples 1 to 5.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 67085-11-4.

Reference:
Patent; Zhuzhou Qianjin Pharmaceutical Co., Ltd.; Peng Kaifeng; Wen Fengqiu; Bai Lu; Li Sanxin; Gong Yun; Li Fujun; (12 pag.)CN105198816; (2018); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem