Synthetic Route of 67021-83-4,Some common heterocyclic compound, 67021-83-4, name is 1H-Benzo[d]imidazol-4-ol, molecular formula is C7H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 164-(2-Trimethylsilanyl-ethoxymethoxy)-1-(2-trimethylsilanyl-ethoxymethyl)-1 H- benzoimidazole (as a mixture with the 7-regioisomer)To a stirred suspension of 1 H-benzoimidazol-4-ol (440 mg, 3.28 mmol) in THF (13 ml.) at room temperature was added NaH (60percent dispersion in mineral oil; 276 mg, 6.89 mmol) in 3 portions over 15 min. The mixture was stirred at room temperature for 1.5 hours before it was heated to 65 0C for 30 min. The THF was removed and replaced with DMF (10 ml.) and the mixture was warmed to 65 0C for 30 min. The mixture was cooled to 10 0C, 2-(trimethylsilyl)ethoxymethyl chloride (1.19 ml_, 6.72 mmol) was added dropwise and the mixture was stirred at room temperature overnight. H2O and Et2O were added, the mixture was filtered and the phases separated. The aqueous phase was extracted into Et2O (x3), dried (MgSO4) and concentrated in vacuo. The product was purified by SiO2 chromatography and followed by trituration with Et2O to provide the title compound (177 mg).
The synthetic route of 67021-83-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; ASTEX THERAPEUTICS LIMITED; HOWARD, Steven; MORTENSON, Paul Neil; HISCOCK, Steven Douglas; WOOLFORD, Alison Jo-Anne; WOODHEAD, Andrew James; CHESSARI, Gianni; O’REILLY, Marc; CONGREVE, Miles Stuart; DAGOSTIN, Claudio; CHO, Young Shin; YANG, Fan; CHEN, Christine Hiu-Tung; BRAIN, Christopher Thomas; LAGU, Bharat; WANG, Yaping; KIM, Sunkyu; GRIALDES, John; LUZZIO, Michael Joseph; PEREZ, Lawrence Blas; WO2010/125402; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem