Category: 67014-36-2

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67014-36-2, name is 5-Amino-6-methyl-1H-benzo[d]imidazol-2(3H)-one, This compound has unique chemical properties. The synthetic route is as follows., Formula: C8H9N3O

1.59 g (6.13 mmol) of ethyl 3-ethoxy-2-[(ethoxycarbonyl)carbamoyl]acrylate (for preparation see: Senda, Shigeo; Hirota, Kosaku; Notani, Jiyoji, Chemical & Pharmaceutical Bulletin (1972), 20(7), 1380-8) and 1.00 g (6.13 mmol) of 5-amino-6-methyl-1,3-dihydro-2H-benzimidazol-2-one were heated to reflux in 46 ml of ethanol for 2 h. Thereafter, 0.69 g (6.13 mmol) of potassium tert-butoxide were added at RT and the reaction mixture was stirred at RT overnight and at reflux for 1 h. For workup, the reaction mixture was admixed with water and acidified with 1N hydrochloric acid. The solid formed was filtered off, washed with water and ethyl acetate, and then dried under reduced pressure at 50 C. This gave 1.46 g (72% of theory) of the target compound. LC-MS (Method 1): Rt=0.52 min; MS (ESIpos): m/z=331 (M+H)+. 1H NMR (400 MHz, DMSO-d6): delta [ppm]=1.22 (t, 3H), 2.08 (s, 3H), 4.16 (q, 2H), 6.89 (s, 1H), 7.03 (s, 1H), 8.19 (s, 1H), 10.77 (s, 1H), 10.78 (s, 1H), 11.65 (s, 1H).

According to the analysis of related databases, 67014-36-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; Fuerstner, Chantal; Ackerstaff, Jens; Straub, Alexander; Meier, Heinrich; Tinel, Hanna; Zimmermann, Katja; Tersteegen, Adrian; Zubov, Dmitry; Kast, Raimund; Schamberger, Jens; Schaefer, Martina; Boerngen, Kirsten; US2015/148340; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 67014-36-2, These common heterocyclic compound, 67014-36-2, name is 5-Amino-6-methyl-1H-benzo[d]imidazol-2(3H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

8.1 g of 5-amino-6-methylbenzimidazolone-(2) was stirred with 250 ml of water and 14.5 ml of 31.5% hydrochloric acid for 1 hour and then diazotized at 0 C. after the addition of ice, by adding an aqueous sodium nitrite solution. EXAMPLE 2 8.1 g of 5-amino-6-methylbenzimidazolone-(2) was diazotized with sodium nitrite solution in the same method as described in Example 1.

The synthetic route of 67014-36-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dominion Colour Corporation; US6706864; (2004); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem