Category: 670-83-7

Related Products of 670-83-7,Some common heterocyclic compound, 670-83-7, name is 2,5-Diphenyl-1H-imidazole, molecular formula is C15H12N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 3 2,5-diphenyl-4-hydroxymethyl-imidazole hydrochloride 5 g (0.0227 mole) of 2,4-diphenyl-imidazole, 0.85 g (0.0283 mole) of paraformaldehyde and 0.1 g of finely ground potassium hydroxide are dissolved in 29 ml of warm methanol and heated under reflux for 90 hours. The solution is then decolourized with activated carbon, filtered and dried. Water and chloroform are added to the residue by stirring; the insoluble solid of both the layers is filtered, washed with water and chloroform and dried. 2.8 g (yield 49.3%) of crude product is thus obtained, which is crystallized from methanol to afford 1.1 g of 2,5-diphenyl-4-hydroxymethyl-imidazole, m.p. 206-207 C. (dec.) By the usual techniques the hydrochloride has been obtained, m.p. about 220 C. (dec.).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,5-Diphenyl-1H-imidazole, its application will become more common.

Reference:
Patent; Zambon S.p.A.; US4560696; (1985); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 670-83-7, name is 2,5-Diphenyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 670-83-7, SDS of cas: 670-83-7

Into a 15mL pressure tube, sequentially add 1p (66.1mg, 0.3mmol), dichloromethane (3mL), 2a (84.7mg, 0.45mmol), dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer (4.7mg, 0.0075 mmol) and silver acetate (100.1 mg, 0.6 mmol), then the pressure-resistant tube was sealed and placed in a 100 C. oil bath for 10 h. After the reaction was completed, the mixture was cooled to room temperature, filtered with suction, dried, and separated through a silica gel column (dichloromethane / methanol / acetic acid = 30/1 / 0.1) to obtain 3p (85.4 mg, 70%) as a white solid product.

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These common heterocyclic compound, 670-83-7, name is 2,5-Diphenyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C15H12N2

a. 1-Ethyl-2,4-diphenyl-1H-imidazole 50% aqueous KOH (40 mmol) and iodoethane (40 mmol) are added to a solution of 2,4-diphenyl-1H-imidazole (30 mmol) in DMF (50 mL), and the mixture is stirred at 40 C. under nitrogen for 16 hours. The reaction mixture is partitioned between water (300 mL) and ethyl acetate (200 mL). The organic layer is separated, washed with water (200 mL*2), dried over anhydrous magnesium sulfate, filtered and evaporated at reduced pressure. The residue is dissolved in xylenes (100 mL) and evaporated at reduced pressure. Chromatography on silica gel (chloroform) provides pure 1-ethyl-2,4-diphenyl-1H-imidazole. 13C NMR (400 MHz, CDCl3) delta=16.16, 41.43, 115.44, 124.57, 126.36, 128.26, 128.32, 128.54, 128.68, 130.55, 134.04, 140.87, 147.48.

The synthetic route of 2,5-Diphenyl-1H-imidazole has been constantly updated, and we look forward to future research findings.