Category: 66121-69-5

Reference of 66121-69-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 66121-69-5 as follows.

After dissolving 1-methylimidazole-4-carbonitrile (1.0 g, 8.0 mmol) in DMF (30 mL), trifluoroacetic hydrazide (1.9 g, 14.8 mmol)After adding and stirring at room temperature for 30 minutes.After adding sodium methoxide (28% methanol solution) to the reaction mixture, the mixture was raised to 140 C and stirred with heating for 48 hours.The reaction mixture was cooled to room temperature, the solvent was blown out, and then extracted with ethyl acetate and water. The organic layers are collected, dehydrated with sodium sulfate, the solids are filtered off and the solvent is blown off. The reaction mixture was purified using silica gel column chromatography to obtain compound (4).(0.35 g, 1.6 mmol) is obtained with a yield of 20%.

According to the analysis of related databases, 66121-69-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Samsung Electronics Co., Ltd.; Cheil Industries Inc.; Pusan National University Institute for Research & Industry Cooperation; Noh Chang-ho; Yoon Ung-chan; Kwon O-hyeon; Choi Byeong-gi; (23 pag.)KR102046153; (2019); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 66121-69-5, name is 1-Methyl-1H-imidazole-4-carbonitrile, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 66121-69-5, Product Details of 66121-69-5

43.4 ml 1 .4M methylmagnesiumbromide in toluene were added dropwise to a mixture of 5.0 g 1 -methyl-1 H-imidazole-carbonitrile in 70 ml diethylether at 0C. After 30 min , the mixture was warmed up to ambient temperature. After 1 h the reaction was quenched with 1 M aqueous HCI solution and neutralised with saturated sodium bicarbonate solution. The reaction mixture was extracted with dichloromethane. The combined organic extracts were dried with magnesium sulfate and concentrated under reduced pressure. The crude material was purified by flash chromatography (dichloromethane/methanol = 98/2) to give the intermediate 3.3. Yield: 4.8 g of 3.3 (75% content; 62% of theory); Analysis: [M+H]+ = 125

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-imidazole-4-carbonitrile, and friends who are interested can also refer to it.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; DAHMANN, Georg; DOLLINGER, Horst; GNAMM, Christian; FIEGEN, Dennis; HOFFMANN, Matthias; LAMB, David, James; KLICIC, Jasna; SCHNAPP, Andreas; WO2013/156608; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 66121-69-5, These common heterocyclic compound, 66121-69-5, name is 1-Methyl-1H-imidazole-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4.1.3 Compounds with formula 3 according to Scheme 1a: Synthesis of 1-(1-Methyl-1H-imidazol-4-yl)-ethanone (3.3) for Example 2-16, 18, 19, 22, 26-28, 32-101, 103-175 43.4 ml 1.4M methylmagnesiumbromide in toluene were added dropwise to a mixture of 5.0 g 1-methyl-1H-imidazole-carbonitrile in 70 ml diethylether at 0 C. After 30 min, the mixture was warmed up to ambient temperature. After 1 h the reaction was quenched with 1M aqueous HCl solution and neutralised with saturated sodium bicarbonate solution. The reaction mixture was extracted with dichloromethane. The combined organic extracts were dried with magnesium sulfate and concentrated under reduced pressure. The crude material was purified by flash chromatography (dichloromethane/methanol=98/2) to give the intermediate 3.3. Yield: 4.8 g of 3.3 (75% content; 62% of theory); Analysis: [M+H]+=125

Statistics shows that 1-Methyl-1H-imidazole-4-carbonitrile is playing an increasingly important role. we look forward to future research findings about 66121-69-5.