Category: 65896-14-2

On September 30, 2014, Marly, Charlotte; Bettschart-Wolfensberger, Regula; Nussbaumer, Paeivi; Moine, Sebastien; Ringer, Simone K. published an article.Computed Properties of 65896-14-2 The title of the article was Evaluation of a romifidine constant rate infusion protocol with or without butorphanol for dentistry and ophthalmologic procedures in standing horses. And the article contained the following:

Objective : To compare the clin. usefulness of constant rate infusion (CRI) protocols of romifidine with or without butorphanol for sedation of horses. Study design : Prospective ‘blinded’ controlled trial using block randomization. Animals : Forty healthy Freiberger stallions. Methods : The horses received either i.v. (IV) romifidine (loading dose: 80 渭g kg-1; infusion: 30 渭g kg-1 hour-1) (treatment R,n = 20) or romifidine combined with butorphanol (romifidine loading: 80 渭g kg-1; infusion: 29 渭g kg-1 hour-1, and butorphanol loading: 18 渭g kg-1; infusion: 25 渭g kg-1 hour-1) (treatment RB,n = 20). Twenty-one horses underwent dentistry and ophthalmic procedures, while 19 horses underwent only ophthalmol. procedure and buccal examination During the procedure, physiol. parameters and occurrence of head/muzzle shaking or twitching and forward movement were recorded. Whenever sedation was insufficient, addnl. romifidine (20 渭g kg-1) was administered IV. Recovery time was evaluated by assessing head height above ground. At the end of the procedure, overall quality of sedation for the procedure was scored by the dentist and anesthetist using a visual analog scale. Statistical analyses used two-way anova or linear mixed models as relevant. Results : Sedation quality scores as assessed by the anesthetist were R: median 7.55, range: 4.9-9.0 cm, RB: 8.8, 4.7-10.0 cm, and by the dentist R: 6.6, 3.0-8.2 cm, RB: 7.9, 6.6-8.8 cm. Horses receiving RB showed clin. more effective sedation as demonstrated by fewer poor scores and a tendency to reduced addnl. drug requirements. More horses showed forward movement and head shaking in treatment RB than treatment R. Three horses (two RB, one R) had symptoms of colic following sedation. Conclusions and clin. relevance : The described protocols provide effective sedation under clin. conditions but for dentistry procedures, the addition of butorphanol is advantageous. The experimental process involved the reaction of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride(cas: 65896-14-2).Computed Properties of 65896-14-2

The Article related to sedivet alvegesic sedative analgesic sedation horse, butorphanol, constant rate infusion, horse, romifidine, sedation, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Computed Properties of 65896-14-2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On May 31, 2009, Schauvliege, Stijn; Van den Eede, Annelies; Duchateau, Luc; Pille, Frederik; Vlaminck, Lieven; Gasthuys, Frank published an article.Recommanded Product: 65896-14-2 The title of the article was Comparison between lithium dilution and pulse contour analysis techniques for cardiac output measurement in isoflurane anaesthetized ponies: influence of different inotropic drugs. And the article contained the following:

Objective: To compare cardiac output (Q虈t) measurements using lithium dilution (LiDCO) and pulse contour anal. (PulseCO) techniques in isoflurane-anesthetized ponies before and during the administration of different inotropic/vasoactive drugs. Study design: Prospective randomized exptl. cross-over trial. Animals: Six ponies aged 5.0 卤 1.6 (4-6.5) years and weighing 286 卤 53 (212-368) kg. Methods: After sedation (romifidine) and induction (midazolam + ketamine), anesthesia was maintained with isoflurane in oxygen. After 90 min (= T0), one of four treatments was administered: saline 0.1 mL kg-1 (S), enoximone 0.5 mg kg-1 IV (E), enoximone followed by dobutamine (0.5 渭g kg-1 minute-1 for 120 min) (ED) or enoximone followed by a calcium chloride infusion (0.5 mg kg-1 minute-1 for 10 min) (EC). Data were recorded for 120 min after T0. The PulseCO (recorded from carotid artery) was calibrated before T0, no further recalibrations were performed. Q虈t was determined with LiDCO (Q虈tLiDCO) and PulseCO (Q虈tPulseCO) simultaneously at T5, T10, T20, T40, T60, T80, T100 and T120. Systemic vascular resistance (SVRLiDCO and SVRPulseCO) were calculated Results: In the saline group, Q虈tPulseCO was 4.9 卤 12.3% lower than LiDCO (p < 0.01), whereas SVRPulseCO was 6.9 卤 14.4% higher than SVRLiDCO (p < 0.01). These differences increased over time (mean 卤 SEM), Q虈t by 0.06 卤 0.03% minute-1 (p = 0.042) and SVR by 0.08 卤 0.03% minute-1 (p = 0.018). Q虈tPulseCO was higher than Q虈tLiDCO in the EC group (1.8 卤 23.3%), but lower than Q虈tLiDCO in groups E (-11.7 卤 20.4%) and ED (-10.0 卤 25.9%) (significant difference between treatments, p < 0.01). The differences in SVR in groups E (20.4 卤 32.0%) and ED (20.7 卤 35.3%) were significantly higher than in groups S (6.9 卤 14.4%) and EC (3.1 卤 22.2%) (p < 0.01). Conclusions and clin. relevance: Pulse contour anal. values deviated significantly from LiDCO measurements in isoflurane-anesthetized ponies. The experimental process involved the reaction of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride(cas: 65896-14-2).Recommanded Product: 65896-14-2

The Article related to lithium dilution pulse contour analysis cardiac output anesthetic isoflo, inotropic vasoactive enoximone dobutamine mayne, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Recommanded Product: 65896-14-2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 31, 2013, Ringer, S. K.; Schwarzwald, C. C.; Portier, K.; Mauch, J.; Ritter, A.; Bettschart-Wolfensberger, R. published an article.Quality Control of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride The title of the article was Blood glucose, acid-base and electrolyte changes during loading doses of alpha2-adrenergic agonists followed by constant rate infusions in horses. And the article contained the following:

The aim of the present study was to investigate changes in blood glucose concentration ([Glu]B), acid-base status and electrolyte concentrations during constant rate infusions (CRI) of two alpha2-adrenergic agonists in seven horses treated in a blinded, randomized, crossover design with xylazine or romifidine. An i.v. (IV) bolus of xylazine (1 mg/kg) or romifidine (80 渭g/kg) was administered followed by an IV CRI of xylazine (0.69 mg/kg/h) or romifidine (30 渭g/kg/h) for 2 h. Blood samples were collected from the pulmonary artery before and after loading doses, during the CRI, and for 1 h after discontinuing drugs.Blood glucose, base excess (BE), pH, partial pressure of carbon dioxide (PvCO2), strong ion difference (SIDest) and bicarbonate concentration ([HCO3std-]B) increased significantly during the CRI with both alpha2-adrenergic agonists. Chloride concentration ([Cl-]B) and anion-gap (AG) decreased significantly compared to baseline. The decrease in sodium concentration ([Na+]B) was only significant with xylazine. From 1 h after starting the CRI onwards, [Glu]B was significantly higher with romifidine compared to xylazine. Except [Glu]B, SIDest, and PvCO2, all variables returned to normal values 1 h after discontinuing xylazine. After stopping romifidine, all variables except pH remained altered for at least 1 h.It was concluded that loading doses of alpha2-adrenergic agonists followed by CRIs produce [Glu]B, acid-base and electrolyte changes. The clin. significance of the reported changes remains to be investigated and absolute values should be interpreted with caution, as fluid boli were used for cardiac output measurements, but may become important during prolonged infusion and in critically ill patients. The experimental process involved the reaction of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride(cas: 65896-14-2).Quality Control of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride

The Article related to anesthetic adrenergic agonist glucose base excess electrolyte horse, acid-base, electrolytes, glucose, romifidine, xylazine, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Quality Control of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem