Some common heterocyclic compound, 6478-73-5, name is 5,6-Dichloro-1H-benzo[d]imidazole, molecular formula is C7H4Cl2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 6478-73-5
Step B: 2-[(S)-1-Phenylethylamino]-4-[5,6-dichlorobenzimidazol-1-yl]pyrimidine To a solution of 100 mg of 5,6-dichlorobenzimidazole in 3 mL of DMF was added 26 mg of NaH (60% dispersion in oil) and the resulting suspension was stirred at room temperature for 15 minutes. Then, 138 mg of 2-[(S)-1-phenethylamino]-4-chloropyrimidine (EXAMPLE 117) was added and the reaction was heated to 100 C. for 3 hours. After cooling to room temperature, the solution was then diluted with 10 mL of H2O and extracted with 2*10 mL EtOAc. The organic phases were then dried over MgSO4 and concentrated under reduced pressure. The residue was purified with preparatory thin-layer chromatography (SiO2, 5% MeOH in CH2Cl2) to yield 205 mg of the title compound as a yellow oil. RF: 0.63 (5% MeOH in CH2Cl2). 1H NMR (500 MHz, CD3OD): delta 8.89 (br S, 1H), 8.36 (s, 1H), 7.86 (s, 1H), 7.74-7.45 (m, 2H), 7.32-7.28 (m, 3H), 7.19 (t, 1H, J=7.0 Hz), 6.99 (d, 1H, J=5.5 Hz), 5.19 (q, 1H, J=7.0 Hz), 1.59 (d, 3H, J=7.0 Hz). Mass Spectrum (ESI) 384 (M+).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6478-73-5, its application will become more common.