Share a compound : 5,6-Dichloro-1H-benzo[d]imidazole

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6478-73-5, its application will become more common.

Some common heterocyclic compound, 6478-73-5, name is 5,6-Dichloro-1H-benzo[d]imidazole, molecular formula is C7H4Cl2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 6478-73-5

Step B: 2-[(S)-1-Phenylethylamino]-4-[5,6-dichlorobenzimidazol-1-yl]pyrimidine To a solution of 100 mg of 5,6-dichlorobenzimidazole in 3 mL of DMF was added 26 mg of NaH (60% dispersion in oil) and the resulting suspension was stirred at room temperature for 15 minutes. Then, 138 mg of 2-[(S)-1-phenethylamino]-4-chloropyrimidine (EXAMPLE 117) was added and the reaction was heated to 100 C. for 3 hours. After cooling to room temperature, the solution was then diluted with 10 mL of H2O and extracted with 2*10 mL EtOAc. The organic phases were then dried over MgSO4 and concentrated under reduced pressure. The residue was purified with preparatory thin-layer chromatography (SiO2, 5% MeOH in CH2Cl2) to yield 205 mg of the title compound as a yellow oil. RF: 0.63 (5% MeOH in CH2Cl2). 1H NMR (500 MHz, CD3OD): delta 8.89 (br S, 1H), 8.36 (s, 1H), 7.86 (s, 1H), 7.74-7.45 (m, 2H), 7.32-7.28 (m, 3H), 7.19 (t, 1H, J=7.0 Hz), 6.99 (d, 1H, J=5.5 Hz), 5.19 (q, 1H, J=7.0 Hz), 1.59 (d, 3H, J=7.0 Hz). Mass Spectrum (ESI) 384 (M+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6478-73-5, its application will become more common.

Some scientific research about 5,6-Dichloro-1H-benzo[d]imidazole

The synthetic route of 6478-73-5 has been constantly updated, and we look forward to future research findings.

Application of 6478-73-5,Some common heterocyclic compound, 6478-73-5, name is 5,6-Dichloro-1H-benzo[d]imidazole, molecular formula is C7H4Cl2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step B – Methyl 5-(5;6-dichbro-1Mbenzimidazoi-1-yf)-3-hydroxy-2~ thiophenecarboxyiateTo a solution of 5,6-dichloro-1 No.-benzimidazoIe (1.26 g, 8.72 mmoi) and methyl 2-ch.oro-3-oxo-2,3-dihydro-2-thiorhohe?ecarboxy.afe (1.49 g, 7.73 mmoi) in DCM (34 mL) was added NaHCO3 (1.70 g, 20.2 mmof) and M methylfmidazole (0.830 g, 10.1 mmo.) and heated at 400C overnight, The reaction mixture was cooled to it and DCM and wafer were added. The layers were separated and the aqueous layer was extracted with DCM. The combined organic layers were dried over Na2SO4 and filtered. S’lca was added to the filtrate and the volstiies were evaporated under reduced pressure and the residue was purified by flash column chromatography (0 to 100% EtOAc:hexane) to afford 1.5 g (65%) of the title compound. 1H NMR (300 MHz, DMSO-£/6) delta 10,88 (s, 1H), 8.76 (s; 1H), S.10 (s, 1H), 7.99 (S1 IH), 7.17 (s, 1H), 3.79 (S, 3H). MS (ESI): 343 {M+Hf.

The synthetic route of 6478-73-5 has been constantly updated, and we look forward to future research findings.

Some scientific research about 6478-73-5

Statistics shows that 5,6-Dichloro-1H-benzo[d]imidazole is playing an increasingly important role. we look forward to future research findings about 6478-73-5.

Related Products of 6478-73-5, These common heterocyclic compound, 6478-73-5, name is 5,6-Dichloro-1H-benzo[d]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 23[0164] Preparation of (4aR, 7R, 8S,8aR) 5, 6-dichloro-1- (8-fluoro-2-phenyl-hexahydro- pyrano [3,2-d] [1,3]dioxin-7-yl)-1 H-benzoimidazole. EMI54.1[0165] To a solution of (4aR, 7S, 8R, 8aR) trifluoromethanesulfonic acid 8-fluoro-2- phenyl-hexahydropyrano [3,2-d] [1, 3] dioxin-7-yl ester (47.2 mg, 0.12 mmol), prepared according to earlier procedures, in 5 mL of DMSO was added 5, 6-dichloro-1H- benzoimidazole (524 mg, 2.8 mmol) and NaH (67 mg, 2.8 mmol). The mixture was stirred at 70 C overnight. After aqueous work-up and extraction with Et2O, The combined organic fractions were washed with brine, dried over Na2S04, filtered, and concentrated in vacuo. The crude product was purified by flash chromatography to give (4aR, 7R, 8S, 8aR) 5, 6-dichloro-1- (8-fluoro-2-phenyl-hexahydro-pyrano [3,2-d] [1,3] dioxin- 7-yl)-1 H-benzoimidazole. [0166] Yield: 29. 4 mg (58%); Rf= 0. 5 (1: 1 EtOAc-hexane). 1H NMR (CDCl3, 300 MHz) 6 3.61-3. 75 (1H, ddd), 3.80 (1H, dt), 4.14 (1H, m), 4.44-4. 51 (3H, m), 4.66 (1H, m), 5.05-5. 21 (1H, d), 5.49 (1H, s), 7.26-7. 44 (5H, m), 7.60 (1H, s), 7.97 (1H, s), 8.51 (1H, s).

Statistics shows that 5,6-Dichloro-1H-benzo[d]imidazole is playing an increasingly important role. we look forward to future research findings about 6478-73-5.

Reference:
Patent; AUSPEX PHARMACEUTICALS, INC.; WO2005/49582; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem