Category: 641571-13-3

Application of 641571-13-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 641571-13-3, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid, This compound has unique chemical properties. The synthetic route is as follows.

6. 3-(4-Methyl-imidazol-l-yl)-N-[4-methyl-3-(9-methyl-8-oxo-3,6,8,9- tetrahydro-S^jy^-tetraaza-cyclopentafalnaphthalen-V-y^-phenyy-S-rrifluoromethyl- benzamide; [00103] 7-(5-Amino-2-methyl-rhohenyl)-9-methyl-3,6,7,9-tetrahydro-3,4,7,9- tetraaza-cyclopenta[a]naphthalen-8-one (10 mg, 0.032 mmol) is mixed with 3-(4-methyl- imidazol-l-yl)-5-trifluoromethyl-benzoic acid (10 mg, 0.037 mmol), DIEA (0.023 ml, 0.128 mmol) and HATU (13 mg, 0.035 mmol) in 0.4 ml DMF at room temperature. After stirring at room temperature for 4 hours, the reaction mixture is concentrated and purified by RP- HPLC to afford the title compound as TFA salt (12 mg, 71%): 1H NMR 400 MHz (DMSO- dbeta) delta 11.99(5, IH), 10.61(5, IH), 9.50(5, IH), 8.53(5, IH), 8.37(m, 2H), 8.07(5, IH), 8.03(5, IH), 7.72(J, IH, J= 2.0Hz), 7.62(d, IH, J= 2.0 Hz), 7.60(4 IH, J= 2.0 Hz), 7.44(f, IH, J= 2.8 Hz), 7.28(rf, IH, J= 8.4 Hz), 6.80(?, IH), 4.84(4 IH, J= 13.2 Hz), 4.63(4 IH, J=U Hz), 3.61(5, 3H), 2.29(5, 3H), 2.05(5, 3H); MS m/z 560.2 (M + 1).

The chemical industry reduces the impact on the environment during synthesis 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid. I believe this compound will play a more active role in future production and life.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 641571-13-3, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid

General procedure: A mixture ofcompound 10 (0.15 g, 0.772 mmol), HOBt (0.23 g,1.70 mmol), EDCI (0.37 g, 1.93 mmol), benzoic acid(0.19 g, 1.54 mmol), and TEA (0.32 mL, 2.32 mmol) indry DMF (20 mL) was stirred at 80 C for 8 h. The mixturewas quenched with water (40 mL), then extracted withethyl acetate (3 x 40 mL). The combined organic layerextracts were washed with brine, dried over anhydrousMgSO4, filtered, and concentrated under reduced pressure.The residue was purified by flash column chromatography.The desired product was obtained as white solid (0.13 g,56.4 %).

The synthetic route of 641571-13-3 has been constantly updated, and we look forward to future research findings.

Reference of 641571-13-3, A common heterocyclic compound, 641571-13-3, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid, molecular formula is C12H9F3N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of 6 compound (10 mg, 0.028 mmol), substituted benzoic acid (0.028 mmol), HOBt (6.8 mg, 0.05 mmol), EDCI (8.05 mg, 0.04 mmol) and TEA (10 muL, 0.07 mmol) in DMF (0.5 mL) was stirred at room temperature overnight. The reaction mixture was diluted with ethyl acetate and washed with saturated aqueous sodium bicarbonate. The organic layer dried over Na2SO4. Purification of column chromatography with Hexane/ethyl acetate = 1:1 to afford compound 7.

The synthetic route of 641571-13-3 has been constantly updated, and we look forward to future research findings.

Application of 641571-13-3, The chemical industry reduces the impact on the environment during synthesis 641571-13-3, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid, I believe this compound will play a more active role in future production and life.

[00106] To a solution of 6-(3-Amino-phenylamino)-l ,3-dihydro-indol-2-one (36 mg, 0.15 mmol) and 3-(4-methyl-imidazol-l-yl)-5-trifluoromethyl-benzoic acid (53 mg, 0.195 mmol) in DMF (1.5 mL) is added N,N-diisopropylethylamine (78 muL, 0.45 mmol) followed by addition of HATU (63 mg, 0.165 mmol). The mixture is stirred at ambient temperature overnight. The mixture is diluted with EtOAc and washed with 10% Na2S2O3 aqueous solution and brine. The organic layer is separated, dried over MgSO4, EPO and concentrated. The crude product is used in the next step without further purification: LC-MS: 492.1 (MH+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid, other downstream synthetic routes, hurry up and to see.

Related Products of 641571-13-3, These common heterocyclic compound, 641571-13-3, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of 5 compound (10 mg, 0.028 mmol), substituted benzoic acid (0.028 mmol), HOBt (6.8 mg, 0.05 mmol), EDCI (8.05 mg, 0.04 mmol) and TEA (10 muL, 0.07 mmol) in DMF (0.5 mL) was stirred at room temperature for overnight. The reaction mixture was dilluted with ethyl acetate and washed with saturated aqueous sodium bicarbonate. The organic layer dried over Na2SO4. Purification of column chromatography with Hexane/ethyl acetate = 1:1 to afford compound 6 as a white solid.

Statistics shows that 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid is playing an increasingly important role. we look forward to future research findings about 641571-13-3.

Reference:
Article; Kim, Mi-Hyun; Kim, Minjung; Yu, Hana; Kim, Hwan; Yoo, Kyung Ho; Sim, Taebo; Hah, Jung-Mi; Bioorganic and Medicinal Chemistry; vol. 19; 6; (2011); p. 1915 – 1923;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some common heterocyclic compound, 641571-13-3, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid, molecular formula is C12H9F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 641571-13-3

PAL-resin 4-methyl-3-nitro-aniline (5g, 5mmol), bis (2-oxo-3-oxazolidinyl) phosphinic chloride (5.09g, 20mmol), DIEA (3. 5mL, 20mmol), and 3- (4-methyl-imidazol-1-yl)-5- trifluoromethyl-benzoic acid (2. 71g, 10.0mmol) are mixed in DMF (50mL) with shaking at room temperature for 18 hours. The resultant mixture is filtered and the resin is washed with DMF (3x50mL), CH2Cl2 (3x50mL), MeOH (3x50mL), and dried under vacuum. lOmgs of this resin is treated with TFA/CH2Cl2/H20 (45/50/5) (20011L) for 30 minutes. LC-MS shows only one peak: observed MS (M + H+) is 405.1 ; calculated MS (M + H+) is 405.11.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 641571-13-3, its application will become more common.

Reference:
Patent; IRM LLC; WO2005/39486; (2005); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 641571-13-3,Some common heterocyclic compound, 641571-13-3, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid, molecular formula is C12H9F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of the carboxylic acid 6m (1.0g, 3.91 mmol) in DMF (18mL), HOBt (0.59g, 4.69 mmol) and EDC (0.82mL, 4.69 mmol) was added 4-methyl-3-nitroaniline (0.71 g, 4.69 mmol) and the mixture was stirred at 25 C for 12 hours. The reaction mixture was concentrated under reduced pressure, redissolved in EtOAc and extracted with 0.5 M NaHCO3 and water. The organic phase was dried over MgSO4, concentrated under reduced pressure and the resulting solid was washed with DCM and hexane affording the desired amide in pure form (1.01g, 64% yield). IR (neat): upsilon? = 3344, 1682, 1654, 1603, 1537, 1524, 1498, 1448, 1407, 1305, 1283, 1255, 1172, 1121, 1103, 1079, 1001, 904, 877, 829, 812, 751, 739, 690, 671, 617, 503, 418 cm-1; MS (ESI), m/z: calcd for C19H16F3N4O3+, 405.11690; found, 405.11716.

The synthetic route of 641571-13-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Universitaet Zuerich; Unzue Lopez, Andrea; Dong, Jing; Lafleur, Karine Anne; Zhao, Hongtao; Frugier, Emilie; Caflisch, Amedeo; Nevado Blazquez, Cristina; EP2924039; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem