641571-11-1 Archives - Page 8 of 8 - Imidazoles-derivatives

Brief introduction of 641571-11-1

The synthetic route of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline has been constantly updated, and we look forward to future research findings.

A common heterocyclic compound, 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, molecular formula is C11H10F3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 641571-11-1.

Example 15; Preparation of Nilotinib.3HCl (crude)3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylbenzoyl chloride dihydrochloride of formula (X-Cl).2HCl (105 gms) was added to dichloromethane (1000 ml) and 3-(trifluoromethyl)-5-(4-methyl-1H-imidazol-1-yl)benzenamine of formula I (71 gms) at 25-40 C. The temperature was raised to reflux point and was stirred at this temperature for 10-12 Hours. The reaction mixture was then cooled to 30-20 C. The obtained slurry was filtered and the solid was washed with dichloromethane (200 ml). The wet product was dried at 40-60 C. under reduced pressure.The X-ray powder diffraction of the obtained product is shown in FIG. 3. The X-ray powder diffraction of the obtained product after exposure to 100% humidity for 96% is shown in FIG. 4. Yield: 90-92% Purity: 85-90% Hydrochloride content (by Argentometry titration): 16.8%.

The synthetic route of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; US2010/16590; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Extended knowledge of 641571-11-1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 641571-11-1, its application will become more common.

Some common heterocyclic compound, 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, molecular formula is C11H10F3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 641571-11-1

To a solution of 3 (500 mg, 2.1 mmol) and 48 (489 mg, 2.1 mmol) in CH2CI2 (10mL) was added pyridine (242 mg, 3.1 mmol), dropwise. The reaction was stirred atroom temperature overnight. Water was added and the mixture was extracted with CH2CI2 twice. The combined organic layers were dried over Na2SO4 and concentrated. The residue was purified by silica gel column chromatography to give 49 (180 mg, 20%) as a slightly yellow solid. LCMS (m/z: m+1): 441 .1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 641571-11-1, its application will become more common.

Reference:
Patent; CARDIO THERAPEUTICS PTY LTD; TREUTLEIN, Herbert; ZENG, Jun; DIXON, Ian; JAMES, Ian; PALMER, James T; (169 pag.)WO2018/165718; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The important role of 641571-11-1

The chemical industry reduces the impact on the environment during synthesis 641571-11-1. I believe this compound will play a more active role in future production and life.

The chemical industry reduces the impact on the environment during synthesis 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, I believe this compound will play a more active role in future production and life. 641571-11-1

0 ~ 5 ,will3- (4-methyl-1H-1-imidazolyl) -5-trifluoromethylaniline(24.1 g, 0.1 mol),Di-tert-butyl dicarbonate (21.8 g, 0.1 mol)And 200 mL of dichloromethane were added to a three-necked reaction flask,Triethylamine (28.5 g, 0.15 mol) was added dropwise with stirring,After that,Heating up to 25 ~ 35 ,Reaction for 12 hours,TLC detection,To the raw material reaction completely.The solvent was removed under reduced pressure,The resulting residue was recrystallized from ethyl acetate to give a white solidN- [3- (4-methyl-1H-1-imidazolyl) -5-trifluoromethylbenzene] tert-butoxycarbonylamine (III)(Tert-butoxycarbonyl protected compound of formula II), 29.5 g,Yield 86.5%.

The chemical industry reduces the impact on the environment during synthesis 641571-11-1. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Suzhou Lixin Pharmaceutical Co., Ltd.; Xu Xuenong; Bao Zhijian; Su Jian; Xue Jia; Gu Xinyu; Huang Dongliang; Chen Wei; Wang Zhe; (6 pag.)CN107188887; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Introduction of a new synthetic route about 641571-11-1

Statistics shows that 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline is playing an increasingly important role. we look forward to future research findings about 641571-11-1.

641571-11-1, Name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, 641571-11-1, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

A mixture of 3 (100 mg, 0.41 mmol), p-toluic acid (42) (56 mg, 0.41 mmol), HATU (312 mg, 0.82 mmol) and DIEA (207 mg, 1 .6 mmol) in DMF (2 mL) was heated at 60 C overnight. After cooling, the reaction was directly purified by reverse prep-HPLC andthen silica gel prep-TLC to give 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5- (trifluoromethyl)phenyl)benzamide (21 mg, 14%) as an off-white solid.

Statistics shows that 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline is playing an increasingly important role. we look forward to future research findings about 641571-11-1.