Category: 641571-11-1

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 641571-11-1, Name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, molecular formula is , belongs to imidazoles-derivatives compound. In a document, author is Ghanbari, A., Application In Synthesis of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline.

Corrosion inhibition performance of three imidazole derivatives on mild steel in 1 M phosphoric acid

The effect of benzimidazole (BI) 2-methyl benzimidazole (2MBI) and 2-aminobenzimidazole (2ABI) on the corrosion of mild steel was evaluated in 1 M phosphoric acid at various concentrations using electrochemical techniques (Electrochemical Impedance Spectroscopy (EIS) and DC polarization) Inhibition of imidazole derivatives was evaluated at concentrations between 5 x 10(-2)-10(-4) M It was observed that inhibition efficiency Increased with increasing inhibitor concentration Adsorption of imidazole derivatives on the metal surface was investigated to consider basic information on the interaction between the inhibitors and the metal surface Flory-Huggins adsorption Isotherm model showed that each inhibitor replaces 3-5 molecules of water on the metal surface (C) 2010 Elsevier B V All rights reserved

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 641571-11-1, in my other articles. Application In Synthesis of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline.

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 641571-11-1, Name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, molecular formula is C11H10F3N3. In an article, author is Yang, Shuang,once mentioned of 641571-11-1, Name: 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline.

Synthesis of s-triazine based tri-imidazole derivatives and their application as thermal latent curing agents for epoxy resin

A series of novel s-triazine based tri-imidazole derivatives were successfully prepared through the substitution reaction of cyanuric chloride with imidazole (IM), 2-methylimidazole (2MI), 2-ethylimidazole (2EI) and 2-ethyl-4-methylimidazole (EMI), respectively. The synthesized tri-imidazole derivatives were applied in epoxy resin (EP) to investigate their curing behaviors and thermal latency. Compared with the EP systems containing the unmodified imidazoles, the curing exothermic peaks of the EP systems containing s-triazine based tri-imidazole derivatives shifted to higher temperature regions. Moreover, the EP systems containing s-triazine based tri-imidazole derivatives had much longer storage stability at room temperature. The s-triazine structure with strong electron withdrawing effect reduced the nucleophilicity of pyridine-like nitrogen atom of imidazole ring, resulting in the suppression of reactivity of the modified imidazole derivatives towards EP at room temperature. Nevertheless, the s-triazine based tri-imidazole derivatives regained fast curing performance towards EP at elevated temperatures. (C) 2017 Elsevier B.V. All rights reserved.

Interested yet? Keep reading other articles of 641571-11-1, you can contact me at any time and look forward to more communication. Name: 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline.

Related Products of 641571-11-1, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 641571-11-1, Name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, SMILES is CC1=C[N](C=N1)C2=CC(=CC(=C2)N)C(F)(F)F, belongs to imidazoles-derivatives compound. In a article, author is EFIMENKO, IA, introduce new discover of the category.

SYNTHESIS AND STRUCTURE OF PALLADIUM(II) MIXED COMPLEXES WITH DNA PURINE OR PYRIMIDINE-BASES AND IMIDAZOLE DERIVATIVES .1.

Palladium(II) mixed ligand complexes with purine or pyrimidine and imidazole derivatives were prepared and characterized by i.r., Raman and electronic spectroscopy. The compounds have the general formula [Pd(L(1))(L(2))X(2))]; where L(1)=adenine, guanine, hypoxanthine, cytosine, 2-aminopyrimidine, 4(6)-hydroxypyrimidine; L(2) = N-methylimidazole, N-ethylimidazole or N-propylimidazole; X = Cl or Br. The complexes are square planar with cis-halogens. The purine, pyrimidine and imidazole bases act as monodentate ligands coordinated via the N(7) of purine and N(3) of pyrimidine and imidazole.

Related Products of 641571-11-1, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 641571-11-1.

Related Products of 641571-11-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A suspension of 1 (0.10 g, 0.40 mmol), 51 (0.13 g, 0.54 mmol), Pd2(dba)3 (25 mg, 0.027 mmol), t-tert-buty phosphine (IM in toluene; 0.1 mL, 0.10 mmol) and potassium tert- butoxide (0.25 g, 2.2 mmol) in dioxane/DMF (1/1; 6 mL) was sealed in a microwave reaction tube and irradiated with microwave at 160 0C for 30 min. After cooling to room temperature, the resulting mixture was filtered and the filtered solid washed with DCM. The filtrate was concentrated and the residue purified by HPLC. The fractions were combined and poured into saturated NaHCO3 solution (20 mL). The combined aqueous layers were extracted withEtOAc (2 x 20 mL) and the combined organic layers washed with brine, dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated and the residue re-dissolved in minimum amount of EtOAc and hexanes added until solid precipitated. After filtration, the title compound was obtained as a light brown solid (23 mg, 13%).[0264] 1K NMR (500 MHz, DMSO-J6): delta 2.20 (s, 3H), 2.33 (s, 3H), 6.93 (dd, J = 3.6, 1.7 Hz, IH), 7.41 (dd, J = 3.6, 2.3 Hz, IH), 7.44 (s, 2H), 7.50 (s, IH), 7.97 (s, IH), 8.20 (d, J = 0.8 Hz, IH), 8.27 (s, IH), 8.46 (s, IH), 11.84 (s, IH)MS (ES+): m/z 455 (M+H)+

The synthetic route of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TARGEGEN INC.; WO2009/49028; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 641571-11-1, These common heterocyclic compound, 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solutionof amine 3-(4-methyl-1H-imidazol-1-yl)-5-(triuoromethyl)aniline (a) (one equivalent) and Et3N(1.5 equivalents) in dry CHCl3 cooled to 0 C was added dropwise to a solution of4-(chloromethyl)benzoyl chloride (4) (one equivalent) in dry CHCl3. The reaction mixture wasstirred at room temperature. The progress was monitored by TLC. Cold water was added to thereaction mixture. The organic layer was separated, and the water layer was extracted by CHCl3 threetimes. The combined organic layers were dried over Na2SO4, filtered, and concentrated under vacuum.The product was purified by column chromatography on silica gel. The white solid 5 was given with 60% yield; m.p. 80-82 C; 1H-NMR (DMSO-d6, 500 MHz) : 10.74 (s, 1H), 8.32 (s, 1H), 8.26 (d,J = 1.0 Hz, 1H), 8.17 (s, 1H), 8.03 (d, J = 8.3 Hz, 2H), 7.77 (s, 1H), 7.66 (d, J = 8.0 Hz, 2H), 7.52 (s, 1H),4.89 (s, 2H), 2.21 (s, 3H); 13C-NMR (DMSO-d6, 125 MHz) : 166.1, 142.2, 141.7, 139.4, 138.4, 135.5, 134.4,129.4, 128.6, 115.4, 114.7, 112.2, 45.8, 14.0; HRMS (ESI+) m/z calculated for C19H16ClF3N3O [M + H]+394.0929, found 394.0927; purity: 97.93% (by HPLC).

Statistics shows that 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline is playing an increasingly important role. we look forward to future research findings about 641571-11-1.

Reference:
Article; Kalinichenko, Elena; Faryna, Aliaksandr; Kondrateva, Viktoria; Vlasova, Alena; Shevchenko, Valentina; Melnik, Alla; Avdoshko, Olga; Belko, Alla; Molecules; vol. 24; 19; (2019);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 641571-11-1, category: imidazoles-derivatives

To a solution of 13 (100 mg, 0.33 mmol) in NMP (2 mL) was added SOd2 (58 mg, 0.49 mmol). The reaction was heated at 90 C for 1 hour before 3 (80 mg, 0.33 mmol) was added. The resulting mixture was stirred at 90 C for 3 hours. The reaction was quenched with water and basified with aqueous NaOH. The mixture was extracted with EtOAc twice. The combined organic layers were washed with brine, dried overNa2SO4 and concentrated. The residue was purified by reverse prep-HPLC and then silica gel prep-TLC to give 4-methyl-N-(3-(4-methyl-1 H-imidazol-1 -yl)-5- (trifluoromethyl)phenyl)-3-((4-phenylpyrimidin-2-yl)amino)benzamide (22 mg, 13%) as a white solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; CARDIO THERAPEUTICS PTY LTD; TREUTLEIN, Herbert; ZENG, Jun; DIXON, Ian; JAMES, Ian; PALMER, James T; (169 pag.)WO2018/165718; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 641571-11-1,Some common heterocyclic compound, 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, molecular formula is C11H10F3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 1; [240] Preparation of N-r3-f4-methylimidazol- l-ylV5-trifluoromethyl-phenyll-4-(4-pyridin-3-yl-Pyrimidin-2-ylaminos)-benzamide; EPO [241] 4-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzoic acid prepared in Preparation 19(242mg, 0.83mmol) and 3-(4-methyl-imidazol- l-yl)-5-trifluoromethyl-phenylamine prepared in Preparation 30 (200mg, 0.83mmol), N,N-dimethyl formamide (10ml), and diethylcyano phosphate ( 0.245ml, 1.658mmol) were added to a reaction vessel, and cooled to 100C. Triethylamine (0.231ml, 1.658mmol) was added thereto. After 30 min, the mixture was mixed at 600C for 15 hr. The mixture was cooled to RT, and an organic layer was obtained with the solution of ethyl acetate and sodium bi carbonate, concentrated under vacuum, and subjected to column chromatography (5: 1/CHC1 :MeOH) to give the titled compound as pale yellow solid.[242] 1H-NMR (DMSO-d , delta)= 2.20 (s,3H), 7.39 (s,lH), 7.56 (d,2H), 8.03 (m,5H), 8.17(s,lH), 8.21 (d,lH), 8.32 (s,lH), 8.49 (d,2H), 8.63 (d,lH), 8.72 (d,lH), 9.36 (s,lH), 10.15 (s, IH); 10.48 (s,lH)

The synthetic route of 641571-11-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IL-YANG PHARM. CO., LTD.; WO2007/18325; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, This compound has unique chemical properties. The synthetic route is as follows., name: 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Example 2[69] Synthesis of 4-methyl-N-[3-(4-methylimidazole-l-yl)-5-trifluoromethyl-phenyl] -3-(4-pyrazine-2-yl-pyrimidine-2-yl amino)benzamide[70][71] Method A[72] A pale yellow solid final compound (18.7g, yield 85%) was obtained by reacting3-(4-methyl-imidazole-l-yl)-5-trifluoromethyl-phenylamine (1Og, 41.46mmol) with 4-methyl -3-(4-pyrazine-2-yl-pyrimidine-2-yl amino)-benzoic acid ethyl ester in a similar manner as described in Method A of Example 1, except that 4-methyl-3-(4-pyrazine-2-yl-pyrimidine-2-yl amino) -benzoic acid ethyl ester (15.3g, 45.60mmol) was used, instead of 4-methyl-3-(4-thiazole-2-yl-pyrimidine-2-yl amino)benzoic acid ethyl ester.[73] 1H-NMR(DMSOd , delta= 2.21(s,3H), 2.38(s,3H), 7.35(s,lH), 7.39(s,lH), 7.54(s,lH),7.63(d,lH), 7.75(d,lH), 8.14(d,2H), 8.38(d,2H), 8.54(d,2H), 8.68(s,lH), 9.06(s,lH), 9.45(s, IH), 10.56(s,lH)

According to the analysis of related databases, 641571-11-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; IL-YANG PHARM. CO., LTD.; KIM, Dong Yeon; CHO, Dae Jin; LEE, Gong Yeal; KIM, Hong Youb; WOO, Seok Hun; WO2010/18895; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 641571-11-1, These common heterocyclic compound, 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A suspension of methyl 4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)benzoate (325 mg, 1mmol) and 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline (241 mg, 1 mmol) in 10 mL anhydrous THF was cooled to -20 C, a solution of tBuOK (672 mg, 6 mmol) in 10 mL anhydrous THF was added. The reaction mixture was warmed to room temperature slowly and stirred at r.t. for 10 h. The reaction was quenched by adding brine, extracted by E.A., the organic phase were combined, then remove the solvent and the residue was purified by column chromatography on silica gel to afford the title product as a white solid (459 mg, 86%).

Statistics shows that 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline is playing an increasingly important role. we look forward to future research findings about 641571-11-1.

Reference:
Article; Wang, Deping; Zhang, Zhang; Lu, Xiaoyun; Feng, Yubing; Luo, Kun; Gan, Jirong; Yingxue, Liu; Wan, Junting; Li, Xiang; Zhang, Fengxiang; Tu, Zhengchao; Cai, Qian; Ren, Xiaomei; Ding, Ke; Bioorganic and Medicinal Chemistry Letters; vol. 21; 7; (2011); p. 1965 – 1968;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Example-19: Preparation of Nilotinib : In 3 lit four necked round bottom flask equipped with mechanical stirrer, thermometer, reflux condenser and an addition funnel, 4-methyl-3-{[4-(3-pyridinyl)-2- pyrimidinyl] amino (benzoic acid (100 g) and N-methyl-2-pyrrolidone (750 ml) was added under nitrogen atmosphere at 25-35C and heated to 60-65C. To this, thionylchloride (30 ml) was added at 60-65C and stirred for 3 hrs at the same temperature. After completion of reaction, a solution of 3 -(4-methyl- lH-imidazol-1- yl)-5-(trifluoromethyl)aniline (86.6 g) in N-methyl-2-pyrrolidone (150 ml) was added to the reaction mass at 60-65C over a period of 45 mins. The reaction mass was further heated to 90-95 C and stirred for 5 hrs at the same temperature. After completion of reaction, the reaction mass was cooled to 75-85C and water (1000 ml) was added to it over a period of 60 mins. Then reaction mass basified with aqueous sodium hydroxide solution at 75-85C; cooled to 35-45C and then stirred for 2 hrs. The reaction mass was further cooled to 5-l0C and stirred for 3 hrs. The solid obtained was filtered, washed with water and dried under vacuum for 12 hrs at 60- 65C to get the title compound. Yield: 145 g.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 641571-11-1.

Reference:
Patent; LAURUS LABS LTD; BOLLU, Ravindra Babu; BANDLAMUDI, Veera Narayana; KUDIRILLA, Vivek Kumar; VEMULA, Rambabu; VASIREDDI, Uma Maheswer Rao; (36 pag.)WO2019/130254; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem