Category: 641571-11-1

Electric Literature of 641571-11-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 641571-11-1 as follows.

Example 30[00103] Form A of the free base of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5- trifluoromethyl-phenyl] -3 -(4-pyridin-3 -yl-pyrimidin-2-ylamino)-benzamide is made according to the following scheme:Eq.)10 EPO [00104] 14.5 g (60.0 mmol) of B6 and 20.8 g (64.8 mmol) of B5 are dissolved in 120 niL tetrahydrofuran absolute at room temperature under inert and water-free conditions. The suspension is cooled to IT 0-5C and 101.0 g (180 mmol) of potassium tert-butoxide solution 20% in tetrahydrofuran were added within 1 hour, maintaining the internal temperature at 0-5C. The reaction mixture is heated gradually to IT 5O0C within 1 hour and then stirred at this temperature for another 1 hour. The reaction mixture (yellow suspension) is quenched at IT 50C by the addition of 50 mL of water. Stirring is stopped, and the two phase system is let to separate. The aqueous (lower) phase is removed. Seeding crystals (0.2 g) of form A are added to the remaining organic phase, and the thin suspension is stirred for 1 hour at 500C during which time crystallization is initiated. Approximately 1.0 mL of acetic acid is added to the organic phase until a pH of ~10 is reached. Solvent (260 mL) is distilled off at 80-1000C (external temperature) under normal pressure, and simultaneously 260 mL ethanol 94% is added keeping the volume constant, i.e., solvent exchange from tetrahydrofuran to ethanol. The suspension is cooled to IT 0-50C within 1 hour, and agitation is continued for another 1 hour. Form A of the free base of 4-methyl-N-[3-(4-methyl-imidazol-l-yl)-5- trifluoromethyl-phenyl] -3 -(4-pyridin-3 -yl-pyrimidin-2-ylamino)-benzamide (crystalline solid) is collected by filtration and washed with 150 mL of cold ethanol 94%. The product is then dried at 500C in vacuo.

According to the analysis of related databases, 641571-11-1, the application of this compound in the production field has become more and more popular.

641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

4-Methyl-3- { [4-(pyridin-3 -yl)pyrimidin-2-yl] amino } berizoic acid (1 Og), carbonyl diimidazole (6.9 g) and imidazole hydrochloride (5.1 g) was added to N-methylpyrrolidin-2-one (200 mL) in a round bottom flask under nitrogen atmosphere at room temperature and stirred for 60 nuns. The reaction mass was heated to 50-55C and stirred for an hour. 5-trifluoromethyl-3-[4-methyl-H1-imidazolyl] aniline (11.8 g) was added to the reaction mass at 50-55C under nitrogen atmosphere. The reaction mass was further heated to 95-105C ad stirred for 24 hrs. After completion of reaction, thereaction mass was cooled to 25-35C, 5% sodium hydroxide solution was added to it and stirred for 1.5 hrs. The precipitated solid was filtered, washed with water followed by acetone and then dried under vacuum at 50-55C to get the title compound (9.1 g).Purity by HPLC: 99.84%; Amine impurity: 0.04%; Acid impurity: 0.03%

The synthetic route of 641571-11-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LAURUS LABS PRIVATE LIMITED; CHAVA, Satyanarayana; GORANTLA, Seeta Rama Anjaneyulu; INDUKURI, Venkata Sunil Kumar; MOTURU, Venkata Rama Krishna Murthy; JAMJANAM, Srivardhana Rao; SELA, Venkata Purushottama Siva Prasad; WO2015/87343; (2015); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some common heterocyclic compound, 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, molecular formula is C11H10F3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

To a solution of 2- (5-ethoxy-6- ( (4-methoxybenzyl) oxy) pyridin-3-yl) -4-ethylpyrimidine-5-carboxylic acid (150 mg 0.366 mmol) 3- (4-methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) aniline (88 mg 0.366 mmol) and Et3N (55.6 mg 0.550 mmol) in 1 4-dioxane (10 mL) stirred under N2at 20 was added DPPA (121 mg 0.440 mmol) in one charge. The reaction mixture was stirred at 80 for 2 h. Then the solution was concentrated. The residue was purified by preparative TLC (DCM/MeOH 101 Rf 0.5) to yield a off white solid of 1- (2- (5-ethoxy-6- ( (4-methoxybenzyl) oxy) pyridin-3-yl) -4-ethylpyrimidin-5-yl) -3- (3- (4-methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) phenyl) urea (50 mg 0.077 mmol 21.07yield) . TLC (DCM/MeOH 101 Rf 0.4) 1HNMR(400 MHz CD3OD) delta9.07 (s 1H) 8.74-8.72 (m 1H) 8.12 (d J 9.3 Hz 2H) 7.98 (br. s. 1H) 7.77-7.75 (m 1H) 7.50 (br. s. 1H) 7.41 (d J 8.6 Hz 2H) 7.35 (s 1H) 6.92 (d J 8.8 Hz 2H) 5.40 (s 2H) 4.17 (d J 7.1 Hz 2H) 3.79 (s 3H) 2.91 (d J 7.5 Hz 2H) 2.26 (s 3H) 1.42 (td J 7.3 14.6 Hz 6H) ES-LCMS m/z 648.3 (M+H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 641571-11-1, its application will become more common.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R & D COMPANY LIMITED; CHEUNG, Mui; DEMARTINO, Michael P.; EIDAM, Hilary Schenck; GUAN, Huiping Amy; QIN, Donghui; WU, Chengde; GONG, Zhen; YANG, Haiying; YU, Haiyu; ZHANG, Zhiliu; (391 pag.)WO2016/37578; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Application In Synthesis of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, 641571-11-1, Name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, SMILES is CC1=C[N](C=N1)C2=CC(=CC(=C2)N)C(F)(F)F, belongs to imidazoles-derivatives compound. In a document, author is Wang Shu-Jun, introduce the new discover.

Chiral Zn prophyrin: Thermodynamic properties and theoretical calculation

The thermodynamic properties of chiral zinc prophyrin (ZnP) coordinating with imidazole derivatives were studied by means of UV-Vis and circular dichroism spectra. The binding constants decreased in the order of K(2-MeIm)>K(Im)>K(N-MeIm)>K(2-Et-4-MeIm) for imidazole derivatives. The results show that the capability of axial coordination increases in the sequence of 2-Et-4-MeImApplication In Synthesis of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 641571-11-1, Name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, formurla is C11H10F3N3. In a document, author is Li, H, introducing its new discovery. SDS of cas: 641571-11-1.

Remarkable rate acceleration of water-promoted nucleophilic substitution of Baylis-Hillman acetate: a facile and highly efficient synthesis of N-substituted imidazole

Without additional reagents, the Baylis-Hillman acetates 2 underwent nucleophilic Substitution reaction with imidazole readily in aqueous THF solution to afford the corresponding N-substituted imidazole derivatives 3 in good to excellent yields. Moreover, the reaction between the in situ generated DABCO salt of Baylis-Hillinan acetates 4 and imidazole occurs in aqueous THF providing the S(N)2 type products 5. The simpler operational procedure, better stereoselectivity and higher efficiency over conventional method make the present protocol practical for the preparation of imidazole derivatives. (c) 2005 Elsevier Ltd. All rights reserved.

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Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 641571-11-1, Name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline. In a document, author is Trofimov, Boris A., introducing its new discovery. Recommanded Product: 641571-11-1.

Reaction of imidazole derivatives with trifluoromethylated arylacetylenes

The nucleophilic addition of imidazole derivatives to trifluoromethylated acetylenes was studied. Unpredictable regioselectivity of the reaction was observed to yield both beta- and alpha-addition products. The reaction is 100% stereoselective to give the corresponding adducts as a Z-isomers only. The observed regioselectivity is discussed in terms of polarization of triple bond using experimental and calculated data. (C) 2016 Elsevier B.V. All rights reserved.

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 641571-11-1, Name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, formurla is C11H10F3N3. In a document, author is Song, Guang-Liang, introducing its new discovery. Recommanded Product: 641571-11-1.

Novel Disubstituted Phenylene-Linked Bis-imidazole Derivatives: Facile Synthesis and Optical Properties

Six novel disubstituted phenylene-linked bis-imidazole derivatives, 3a-3f, were prepared by a one-pot, microwave-assisted method under solvent-free conditions, in yields ranging from 61.6 to 85.6%. The new compounds were characterized by H-1-and C-13-NMR, UV/VIS, and fluorescence spectroscopy, and mass spectrometry, as well as by elemental analyses. The influence of substituents and solvents on the optical properties of 3a-3f was investigated. It was found that there is little influence on absorption and excitation spectra in contrast to emission spectra. Compounds 3a-3f exhibit strong fluorescence in solution, their fluorescence quantum yields ranging from 0.27 to 0.96.

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Electric Literature of 641571-11-1, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 641571-11-1, Name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, SMILES is CC1=C[N](C=N1)C2=CC(=CC(=C2)N)C(F)(F)F, belongs to imidazoles-derivatives compound. In a article, author is Jayabharathi, Jayaraman, introduce new discover of the category.

Synthesis, Structure, Luminescent and Intramolecular Proton Transfer in Some Imidazole Derivatives

A group of novel 2-aryl imidazole derivatives were synthesized and characterized by NMR spectra, X-ray, mass and CHN analysis. An excited state intramolecular proton transfer (ESIPT) process in hydroxy imidazoles (dmip and dmtip) have been studied using emission spectroscopy and it was detected that the two distinct ground state rotamers of I and II are responsible for the normal and the tautomer emission respectively. In hydrocarbon solvent, the tautomer emission predominates over the normal emission for both dmip and dmtip. This reveal that rotamer II is responsible for the tautomer emission and it is stabler than rotamer I which causes the normal emission. In alcoholic solvent like ethanol, a dramatic enhancement of normal emission is observed which was due to increased solvation, the more polar rotamer I become stabler than rotamer II. In dioxane-water mixtures it is observed that the addition of water inhibits the ESIPT process due to the formation of the intermolecular hydrogen bonding involving water. DFT calculations on energy, dipole moment, charge distribution of the rotamers in the ground and excited states of the imidazole derivatives were performed and discussed. PES calculation indicates that the energy barrier for the interconversion of two rotamers is too high in the excited state than the ground state.

Electric Literature of 641571-11-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 641571-11-1.

Related Products of 641571-11-1, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 641571-11-1, Name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, SMILES is CC1=C[N](C=N1)C2=CC(=CC(=C2)N)C(F)(F)F, belongs to imidazoles-derivatives compound. In a article, author is Majumdar, K. C., introduce new discover of the category.

Indium(III) Chloride Catalyzed One-Pot Multicomponent Synthesis of Chromenone- and Quinolone-Annulated Imidazole Derivatives

A one-pot multicomponent strategy for the synthesis of chromenone- and quinolone-annulated imidazole derivatives from easily available starting materials has been achieved via an indium(III) chloride catalyzed domino reaction. The protocol is simple, step-economic, and less hazardous, and also provides good yields of the products.

Related Products of 641571-11-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 641571-11-1 is helpful to your research.

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 641571-11-1, Name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, molecular formula is , belongs to imidazoles-derivatives compound. In a document, author is Jayabharathi, Jayaraman, Quality Control of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline.

A study on the binding interaction between the imidazole derivative and bovine serum albumin by fluorescence spectroscopy

The interaction between the imidazole derivative 2-(2,4-difluorophenyl)-1-phenyl-1H-imidazo[4,5-f] [1,10]phenanthroline (dfppip) and bovine serum albumin (BSA) was investigated by fluorescence and UV-vis absorbance spectroscopy. From the experimental results, it was found that the imidazole derivative has strong ability to quench the intrinsic fluorescence of BSA by forming complexes. Electrostatic interactions play an important role to stabilize the complex. The binding constants and the number of binding sites have been determined in detail. The distance (r) between the donor and the acceptor was obtained according to fluorescence resonance energy transfer (FRET). Conformational changes of BSA were observed from synchronous fluorescence spectroscopy. The effect of metal ions such as Cu2+, Zn2+, Ca2+, Mg2+, Ni2+, Co2+ and Fe2+ on the binding constants between the imidazole derivative and BSA were also studied. (C) 2011 Elsevier B.V. All rights reserved.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 641571-11-1, in my other articles. Quality Control of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline.