McKay, A. F. et al. published their research in Canadian Journal of Chemistry in 1954 | CAS: 64038-64-8

Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C6H8N2O2S

Amino acids. I. Preparation and properties of glycocyamidine was written by McKay, A. F.;Braun, R. O.;Hatton, W. G.. And the article was included in Canadian Journal of Chemistry in 1954.COA of Formula: C6H8N2O2S This article mentions the following:

Free guanidine with Et glycinate gave 29% glycocyamidine (I). Heating guanidine carbonate with glycine produced no I, but 55% guanidinoacetic acid (II). This was esterified with EtOH by azeotropic removal of H2O by C6H6 from an alc. HCl solution to produce Et guanidinoacetate-HCl (III); picrate, m. 189.5-90.5掳. Aqueous III treated with Amberlite IRA-400 and the resulting solution evaporated gave a mixture of I (identified as its picrate, m. 214.5-15.5掳) and II. I was nitrated in Ac2O-HNO3 to glycocyamidine nitrate, m. 145掳 (from EtOH). I and II may be separated and identified by paper chromatog. with BuOH-H2O-HOAc (4.2:4.2:1) as eluent. In the experiment, the researchers used many compounds, for example, Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8COA of Formula: C6H8N2O2S).

Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C6H8N2O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chakrabarti, Jiban K. et al. published their research in Journal of the Chemical Society in 1991 | CAS: 64038-64-8

Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Formula: C6H8N2O2S

A regiospecific rearrangement of 4(5)-substituted 2-phenacylthio-1H-imidazoles to 4-substituted 2-mercapto-1-phenacyl-1H-imidazoles was written by Chakrabarti, Jiban K.;Smith, Colin W.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1991.Formula: C6H8N2O2S This article mentions the following:

4(5)-Substituted 2-phenacylthio-1H-imidazoles I (R = CO2Et, Ph) thermally rearrange to give 2-mercapto-1-phenacyl-1H-imidazoles II. In the experiment, the researchers used many compounds, for example, Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8Formula: C6H8N2O2S).

Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Formula: C6H8N2O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chakrabarti, Jiban K. et al. published their research in Journal of the Chemical Society in 1991 | CAS: 64038-64-8

Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Formula: C6H8N2O2S

A regiospecific rearrangement of 4(5)-substituted 2-phenacylthio-1H-imidazoles to 4-substituted 2-mercapto-1-phenacyl-1H-imidazoles was written by Chakrabarti, Jiban K.;Smith, Colin W.. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1991.Formula: C6H8N2O2S This article mentions the following:

4(5)-Substituted 2-phenacylthio-1H-imidazoles I (R = CO2Et, Ph) thermally rearrange to give 2-mercapto-1-phenacyl-1H-imidazoles II. In the experiment, the researchers used many compounds, for example, Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8Formula: C6H8N2O2S).

Ethyl 2-mercapto-1H-imidazole-4-carboxylate (cas: 64038-64-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Formula: C6H8N2O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

New learning discoveries about 64038-64-8

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-mercapto-1H-imidazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Application of 64038-64-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 64038-64-8, name is Ethyl 2-mercapto-1H-imidazole-4-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 2-thioxo-2,3-dihydro-1H-imidazole-4-carboxylic acid ethyl ester (5.81 mmol) and chloroacetone (6.97 mmol) in EtOH (8.0 mL) is heated at reflux for 120 min. The solvents are removed in vacuo and POCl3 (87.1 mmol) is added. The mixture is stirred at RT for 16 h and at reflux for 4 h, concentrated in vacuo and diluted with chloroform. Ice water is added and the mixture is neutralized by addition of Na2CO3. The layers are separated and the aq. layer is extracted with chloroform. The combined organic layers are dried over Na2SO4 and concentrated in vacuo to give a crude product which is purified by CC (heptane/EtOAc 9/1 to heptane/EtOAc 3/7). LC-MS: tR=0.73 min; [M+H]+=211.0.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-mercapto-1H-imidazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.