Synthetic Route of 6341-92-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6341-92-0 as follows.
Step 1 2-( -amino-3-chlorophenyl)-7-chloroquinoline-4-carboxylic acid [00425] A solution of l-(4-amino-3-chlorophenyl)ethan-l-one (4.2 g, 24.9 mmol) in EtOH (20 mL) was added to a solution of 6-chloroindoline-2,3-dione (3 g, 16.6 mmol) in 6 M aqueous KOH (20 mL) at 100C. The reaction was monitored by LC-MS until the starting material consumed. Then the reaction mixture was concentrated to remove EtOH, then adjusted the pH to 4-5. The precipitate was filtered to give the desired product 2-(4-amino-3-chlorophenyl)-7- chloroquinoline-4-carboxylic acid (4.1 g, 74.5%) as red solid.
According to the analysis of related databases, 6341-92-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NEW YORK UNIVERSITY; UNIVERSITY OF ALBANY; SCHMIDT, Ann, Marie; RAMASAMY, Ravichandran; SHEKHTMAN, Alexander; RAI, Vivek; MANIGRASSO, Michaele, B.; (179 pag.)WO2017/184547; (2017); A1;,
Indoline – Wikipedia,
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