Category: 62457-94-7

Demirayak, Seref published the artcileSynthesis of some 6,8-diarylimidazo[1,2-a]pyrazine derivatives by using either reflux or microwave irradiation method and investigation of their anticancer activities, Product Details of C10H7ClN2O, the main research area is diarylimidazopyrazine anticancer agent structure activity relationship human cancer leukemia; microwave irradiation alkylation heterocyclization diarylimidazopyrazine pyrazine derivative preparation.

The preparation of 6,8-diarylimidazo[1,2-a]pyrazines, e.g. I, via the reaction of 1-(2-aryl-2-oxoethyl)-2-aryloylimidazole derivatives, e.g. II, with ammonium acetate in acetic acid utilizing a new method, is reported. Anticancer activities of the compounds obtained were evaluated and the activity values were reported.

Journal of Heterocyclic Chemistry published new progress about Alkylation. 62457-94-7 belongs to class imidazoles-derivatives, name is (4-Chlorophenyl)(1H-imidazol-2-yl)methanone, and the molecular formula is C10H7ClN2O, Product Details of C10H7ClN2O.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Foldesi, Tamas published the artcileEfficient synthesis of a new compound family, 9-aryl-5H-imidazo[2,1-d][1,2,5]triazepin-6(7H)-ones, SDS of cas: 62457-94-7, the main research area is imidazole aroyl alkylation hydrolysis protection acid ring closure; triazepinone aryl imidazo preparation.

Representatives of a new compound family, 9-aryl-5H-imidazo[2,1-d][1,2,5]triazepin-6(7H)-ones I (Ar = Ph, 4-FC6H4, 4-ClC6H4, 3-ClC6H4, 4-MeOC6H4, 3-CF3C6H4, 4-NO2C6H4, 2-thienyl) have been synthesized. As structural analogs of biol. active 1-aryl-2,3-benzodiazepine-4-ones, these compounds are potential drug candidates in the diseases of the central nervous system. An efficient five-step synthesis starting from imidazole is described here for the preparation of the target compounds Shorter routes have also been studied, however, these attempts failed.

Tetrahedron published new progress about Alkylation. 62457-94-7 belongs to class imidazoles-derivatives, name is (4-Chlorophenyl)(1H-imidazol-2-yl)methanone, and the molecular formula is C10H7ClN2O, SDS of cas: 62457-94-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kim, Moon H. published the artcileThe design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors, Product Details of C10H7ClN2O, the main research area is indolinone derivative preparation antitumor receptor tyrosine kinase inhibitor pharmacokinetic.

Variously substituted indolin-2-ones were synthesized and evaluated for activity against KDR, Flt-1, FGFR-1 and PDGFR. Extension at the 5-position of the oxindole ring with Et piperidine (I) proved to be the most beneficial for attaining both biochem. and cellular potencies. Further optimization of I to balance biochem. and cellular potencies with favorable ADME/ PK properties led to the identification of II, a compound with a clean CYP profile, acceptable pharmacokinetic and toxicity profiles, and robust efficacy in multiple xenograft tumor models.

Bioorganic & Medicinal Chemistry Letters published new progress about Angiogenesis. 62457-94-7 belongs to class imidazoles-derivatives, name is (4-Chlorophenyl)(1H-imidazol-2-yl)methanone, and the molecular formula is C10H7ClN2O, Product Details of C10H7ClN2O.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Guo, Jing published the artcileDesign, synthesis, structure-activity relationships study and X-ray crystallography of 3-substituted-indolin-2-one-5-carboxamide derivatives as PAK4 inhibitors, Product Details of C10H7ClN2O, the main research area is indolinone preparation SAR docking PAK4 inhibitor crystal mol structure; Indolin-2-one; X-ray crystallography; p21-activated kinase 4.

We have previously described the identification of indolin-2-one-5-carboxamides as potent PAK4 inhibitors. This study expands the structure-activity relationships on our original series by presenting several modifications in the lead compounds, I and II. A series of novel derivatives was designed, synthesized, and evaluated in biochem. and cellular assay. Most of this series displayed nanomolar biochem. activity and potent antiproliferative activity against A549 and HCT116 cells. The representative compound III exhibited excellent enzyme inhibition (PAK4 IC50 = 25 nM) and cellular potency (A549 IC50 = 0.58 μM, HCT116 IC50 = 0.095 μM). An X-ray structure of compound III bound to PAK4 was obtained. Crystallog. anal. confirmed predictions from mol. modeling and helped refine SAR results. In addition, Compound III displayed focused multi-targeted kinase inhibition, good calculated drug-likeness properties. Further profiling of compound III revealed it showed weak inhibitory activity against various isoforms of human cytochrome P 450.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 62457-94-7 belongs to class imidazoles-derivatives, name is (4-Chlorophenyl)(1H-imidazol-2-yl)methanone, and the molecular formula is C10H7ClN2O, Product Details of C10H7ClN2O.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem