Electric Literature of 62366-53-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 62366-53-4 as follows.
EXAMPLE 1 N-[1-(2-[1H-indol-3-yl]ethyl)piperidin-4-yl]-1-methyl-1H-imidazole-2-carboxamide A melt of 3-[2-(4-amino-1-piperidyl)ethyl]indole (1.0 g, 4.11 mmol), 2-hydroxypyridine (0.3 g, 3.16 mmol) and 2-methoxycarbonyl-1-methyl-1H-imidazole (0.57 g, 4.07 mmol) was heated at 160 C. for 3 hours under N2. More 2-methoxycarbonyl-1-methyl-1H-imidazole (5 drops) was added and heating continued for a further 11/2 hours. The mixture was cooled and chromatographed on silica (100-200 aktiv) eluding with absolute ethanol. The title compound was isolated as a brown glass (0.97 g,). This was dissolved in hot ethanol (ca. 10 cm3) and ethanolic HCl added to give an acidic solution from which the dihydrochloride of the title compound crystallized on cooling in ice, 0.48 g, m.p. 250-53 C. (on heating from cold sample gums 140-160 C., crystallises 225-40, starts to decompose at 245 then melts as above). Analysis: Found: C, 56.60; H, 6.23; N, 16.86% C20 H25 N5 0.2HCl requires: C, 56.61; H, 6.41; N, 16.50%.
According to the analysis of related databases, 62366-53-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; John Wyeth & Brother Limited; US4772617; (1988); A;,
Imidazole – Wikipedia,
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