Category: 6232-92-4

These common heterocyclic compound, 6232-92-4, name is 6-Nitro-1H-benzo[d]imidazol-2-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H6N4O2

VIII-1 7-nitropyrimido[1,2-a]benzimidazole hydrochloride and 8-nitropyrimido[1,2-a]benzimidazole hydrochloride (Compounds No. XXVI)A mixture of 2 g (11.2 mmol) of 2-amino-5-nitro-benzimidazole (J. Med. Chem., 1995, 38(20), 4098-4105) and of 3.6 ml (15 mmol) of 1,1,3,3-tetraethoxypropane in 50 ml of ethanol and 2 ml of concentrated hydrochloric acid is refluxed for 12 hours. 1.97 g of a beige precipitate is recovered by filtration and is dried under reduced pressure. A mixture of isomers is obtained, which is used as it is in the subsequent step.

The synthetic route of 6-Nitro-1H-benzo[d]imidazol-2-amine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SANOFI-AVENTIS; US2009/42873; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 6232-92-4, A common heterocyclic compound, 6232-92-4, name is 6-Nitro-1H-benzo[d]imidazol-2-amine, molecular formula is C7H6N4O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Benzoyl chloride (0.51 mL, 4.4 mmol) was added to a solution of 2-amino-5-nitro-benzoimidazole (0.712 g, 4.00 mmol) in pyridine (15 mL) and the mixture was heated to 100°C for 0.5 h. Additional benzoyl chloride (0.19 mL, 1.6 mmol) was added and heating was continued for another 0.5 h. After removal of the solvent, the residue was treated with water (10 mL). The undissolved material was separated by filtration and washed with water (2 x 10 mL). After recrystallisation from pyridine (9 mL) / water (2 mL), N-(5-nitro-benzoimidazol-2-yl)benzamide (0.588 g, 2.08 mmol, 52 percent) was obtained. LC/ESI-MS: m/z = 283 [M+H]+; m/z = 281 [M-H]-; Rt =3.74 min.

The synthetic route of 6232-92-4 has been constantly updated, and we look forward to future research findings.

6232-92-4, name is 6-Nitro-1H-benzo[d]imidazol-2-amine, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C7H6N4O2

A mixture of 4-bromo-1H-imidazole (1.0 g, 6.80 mmol) in dimethylformamide (5 mL) was stirred at 0C, to which was added sodium hydride, 60% suspension in oil, (326 mg, 8.20 mmol). The reaction mixture was warmed to room temperature and stirred for 30 minutes, followed by dropwise addition of 2-bromopropane (0.70 mL, 7.48 mmol). The reaction mixture was stirred at room temperature for 15 hours under nitrogen, then quenched with water (10 mL) and extracted with ethyl acetate (3 x 15 mL). The combined organic extracts were washed with water (20 mL) and extracted with 1M hydrochloric acid (3 x 20 mL). The combined acidic extracts were washed with ethyl acetate (20 mL), then basified with ammonium hydroxide (pH 12), and extracted with ethyl acetate (3 x 20 mL). The combined organic extracts were dried (Na2SO4), filtered and concentrated. Preparative HPLC, eluting with an ethyl acetate- isohexane gradient, gave the product as a pale brown oil (380 mg, 30%) 8 (1H, 400MHz, CDCl3) 1.47 (6H, d, J = 6.8Hz), 4.28-4. 32 (1H, m), 6.92 (1H, d, J = 1.5 Hz), 7.40 (1H, d, J = 1.5 Hz). MS (ES+) 189,191 ([MH]+).

The synthetic route of 6232-92-4 has been constantly updated, and we look forward to future research findings.