In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6232-91-3 as follows. SDS of cas: 6232-91-3
2-Amino-5-methoxy-1H-benzimidazole was obtained from 4-methoxybenzene-1,2-diamine following the reported operation. 17 To a solution of N-carbobenzyloxy-l-proline (2.49 g, 10.0 mmol, 1.0 equiv) and 2-amino-5-methoxy-1H-benzo[d]imidazole (1.79 g, 11.0 mmol, 1.1 equiv) in CH2Cl2 (30.0 mL) N,N’-dicyclo-hexylcarbodiimide (2.26 g, 11.0 mmol, 1.1 equiv) and 4-dimethylamino pyridine (1.34 g, 11.0 mmol, 1.1 equiv) were added at 0 ¡ãC under N2 atmosphere. The reaction mixture was stirred for 30 min at 0 ¡ãC, then at room temperature for 24 h. The reaction mixture was filtrated through silica gel pad (SiO2 15 g) to remove dicyclohexylurea. Further purification was through flash column chromatography (Methanol/DCM=1:10). 1H NMR (400 MHz, CHCl3-d): delta 7.50-7.30 (4H, m), 7.20-6.80 (4H, m), 5.15-5.05 (2H, m), 4.60-4.40 (1H, m), 3.84 (3H, d, J=7.80 Hz), 3.72-3.48 (2H, m), 2.38-2.20 (1H, m), 2.10-1.75 (3H, m). 13C NMR (400 MHz, CHCl3-d): delta 179.3, 156.6, 154.5, 146.6, 136.7, 128.3, 128.0, 127.7, 127.4, 111.9, 66.5, 59.4, 55.7, 46.8, 30.8, 23.3. HRMS (ESI): m/z [M+H+] calcd for C21H23N4O4 395.1719, found 395.1714.
According to the analysis of related databases, 6232-91-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Tang, Gongkun; Guen, Uemit; Altenbach, Hans-Josef; Tetrahedron; vol. 68; 49; (2012); p. 10230 – 10235,6;; ; Article; Tang, Gongkun; Guen, Uemit; Altenbach, Hans-Josef; Tetrahedron; vol. 68; 49; (2012); p. 10230 – 10235;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem