Category: 621-72-7

Application of 621-72-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 621-72-7, name is 2-Benzyl-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Metallic Na (76 mg,3.3 mmol) was added to t-BuOH (30 ml), and the mixturewas heated under reflux until effervescence ceased. Thenazole 3b-d or 6b,d,e (3 mmol) and 3,5-dibromo-1-(1,1-dioxidothietan-3-yl)-1H-1,2,4-triazole (1) (0.99 g, 3 mmol)were added. The reaction mixture was heated under refluxfor 2 h (for compounds 4b-d, 7d,e) or 3 h (for compound7b). The solvent was evaporated under reduced pressure,and H2O (15 ml) was added to the residue. The precipitatewas filtered off, dried at 60C, and recrystallized from asuitable solvent.

The synthetic route of 2-Benzyl-1H-benzo[d]imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Makarova, Nadezhda N.; Klen, Elena E.; Khaliullin, Ferkat ?.; Chemistry of Heterocyclic Compounds; vol. 55; 9; (2019); p. 823 – 826; Khim. Geterotsikl. Soedin.; vol. 55; 9; (2019); p. 823 – 826,4;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 621-72-7, name is 2-Benzyl-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 621-72-7, Recommanded Product: 621-72-7

To the reaction vessel was added 8.2 g of dibazole,63 g of 10 wt% hydrochloric acid solution and 1.2 g of activated carbon,Air was introduced into the reaction vessel while stirring, and the temperature was raised to 95 C.The reaction was stirred for 10 hours while the reaction was completed, and the air was stopped.Drop to 15 C, filter, and evaporate the filtrate under reduced pressure to give 8.5 g of crude material;The crude product was mixed with 70 g of anhydrous methanol and stirred and dissolved at 55 C.The mixture was filtered while hot, and the filtrate was stirred at 0 C for 3 hours, and filtered.Drying, 7.8 g of diazol oxidized impurity reference substance was obtained, and the yield was 89.3%.The purity was determined by HPLC to be 99.95%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Benzyl-1H-benzo[d]imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Wuhan Xian Lu Pharmaceutical Technology Co., Ltd.; Huang Li; Ning Fan; Wu Bo; Wang Ge; Xie Shuwei; Chen Weijiang; (6 pag.)CN108863946; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

621-72-7, name is 2-Benzyl-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 2-Benzyl-1H-benzo[d]imidazole

Under an oxygen atmosphere, 0.30 mmol of 2-benzylbenzimidazole (1 g) and 2 mL of dimethyl sulfoxide were sequentially added to the Schlenk reaction tube.The reaction was stirred under constant temperature in an IKA (constant temperature heating magnetic stirrer) for 48 h. After the reaction is completed, it is cooled to room temperature. Quenched with distilled water.It was then extracted with ethyl acetate (3 x 20 mL). The organic layers were combined and dried over anhydrous sodium sulfate. Pure target product by column chromatography 2g (52.6mg, 79%).

The synthetic route of 621-72-7 has been constantly updated, and we look forward to future research findings.

Reference of 621-72-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 621-72-7, name is 2-Benzyl-1H-benzo[d]imidazole, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Sodium hydride (0.53 g, 6.6 mmol, 60% oil dispresion) was added to the stirred solution of the corresponding azole (3.3 mmol) in anhydrous THF (2 mL) at room temperature. After 15 min, freshly prepared 2-(chloromethyl)-4,5-dihydro-1H-imidazole 2 (0.47 g, 4.0 mmol) was added and the reaction mixture was stirred at ambient temperature for 6 h. The N-alkylation products 3, 5, 7 and 8 were isolated upon quenching the reaction mixture with water (5 mL) followed by extraction with dichloromethane (3 ¡Á 5 mL). The combined organic layers were dried over anhydrous sodium sulfate and evaporated under reduced pressure. The oily residue thus obtained was purified on silica with use of chromatotron (Et3N/MeOH/AcOEt 1:5:100). All products were very polar with Rf values close to 0.05.The N-alkylation reaction of indazoles (1) provided the desired N1 substituted products (3) along with the N2 substituted side product. The latter compounds demonstrated considerably lower Rf than 3 and were not isolated in pure form. The alkylation reactions of benzotriazoles 6a and 6c allowed the isolation of N1 substituted products 7a-b (higher Rf) and N2 isomer 8b (lower Rf). However, in the case of 4-methyl-benzotriazole 6b only the N2 substituted isomer 8a was isolated as a pure product.The products 3, 5, 7 and 8 were then converted into water-soluble hydrochloride salts suitable for biological tests with use of methanolic hydrochloric acid solution or by passing gaseous hydrogen chloride through dichloromethane solution of the corresponding free base.

The chemical industry reduces the impact on the environment during synthesis 2-Benzyl-1H-benzo[d]imidazole. I believe this compound will play a more active role in future production and life.

Reference:
Article; Saczewski, Jaroslaw; Hudson, Alan; Scheinin, Mika; Rybczynska, Apolonia; Ma, Daqing; Saczewski, Franciszek; Laird, Shayna; Laurila, Jonne M.; Boblewski, Konrad; Lehmann, Artur; Gu, Jianteng; Watts, Helena; Bioorganic and Medicinal Chemistry; vol. 20; 1; (2012); p. 108 – 116;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem