Category: 6160-65-2

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6160-65-2 as follows. Computed Properties of C7H6N4S

4-Aminobenzoic acid (5 mmol) was slowly added to a solution of TCDI (6 mmol) and TEA(5.5 mmol) in DCM (7.5 mL) at 0 C. The mixture was stirred for 2h at 0 C and then added dropwise to 4Maqueous HCl (9 mL). The precipitation was filtered and washed with 1M aqueous HCl (1mL2). Ther esulting sold was dried to aord 4-isothiocyanatobenzoic acid in yield of 90%. Methyl 2-cyanoacetate(2 mmol) followed by a solution of 4-isothiocyanatobenzoic acid (2 mmol) in anhydrous DMF (2 mL)were added to a cold suspension of powdered KOH (4 mmol) in dry DMF (2 mL). The mixture was stirred at room temperature for 0.5 h, then cooled again to 0 C, treated with a solution of 2-chloroacetylchloride (3 mmol) in anhydrous DMF (2 mL) and stirred at room temperature overnight. The mixturewas poured into ice-cold water, and the resulting precipitate was filtered o, dried, and crystallizedfrom DCM-EtOH to give intermediate IM in yield of 68%.

According to the analysis of related databases, 6160-65-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zeng, Fanxun; Quan, Lina; Yang, Guantian; Qi, Tiantian; Zhang, Letian; Li, Shiliang; Li, Honglin; Zhu, Lili; Xu, Xiaoyong; Molecules; vol. 24; 15; (2019);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 6160-65-2,Some common heterocyclic compound, 6160-65-2, name is 1,1′-Thiocarbonyldiimidazole, molecular formula is C7H6N4S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stirring solution of 1,1?-thiocarbonyldiimidazole (1.2 equiv) in5 mL of DMF at 50 C was added a solution of TEA (1 equiv) and amine5 (1 equiv) in DMF dropwise. The resulting solution stirred at roomtemperature for 1-24 h and was monitored by TLC. The resulting crudesolution of the isothiocyanate was used in the next step without purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1′-Thiocarbonyldiimidazole, its application will become more common.

Reference:
Article; Chapa, Jorge De La; Valdez, Matthew; Ruiz, Franscisco; Gonzales, Keith; Mitchell, Wes; McHardy, Stanton F.; Hart, Matthew; Polusani, Srikanth R.; Gonzales, Cara B.; Bioorganic and Medicinal Chemistry; vol. 27; 1; (2019); p. 208 – 215;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6160-65-2, name is 1,1′-Thiocarbonyldiimidazole, This compound has unique chemical properties. The synthetic route is as follows., 6160-65-2

Amine (Intermediate A47,16 g, 0.0437 mol) was dissolved in pyridine (200 mL). To this solution was added 1,1′-thiocarbonyldiimidazole (11.68 g, 0.0. 655 mol) and stirred at room temperature overnight under argon. To the reaction mixture was added water (400 mL) and stirred for 1 hr. The resulting solid was collected, washed with water (600 mL) and dried to give 16.9 g (95%) of the title compound, benzimidazolethiol.

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Reference:
Patent; GARST, Michael, E.; SACHS, George; SHIN, Jai, Moo; WO2004/9583; (2004); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

6160-65-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6160-65-2, name is 1,1′-Thiocarbonyldiimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

4-Aminobenzoic acid (5.00 g, 36.5 mmol) was added to a methylene chloride solution (51 mL) of thiocarbonyldiimidazole (8.45 g, 47.4 mmol) and triethylamine (5.6 mL, 40.2 mmol) at an internal temperature of at most 5 C., followed by stirring under cooling with ice for one hour. The mixture was dropped to a separately prepared mixed solution of concentrated hydrochloric acid (12.2 mL, 140.5 mmol) and n-heptane (51 mL) so that the internal temperature became from 25 C. to 30 C., whereupon a pale yellow suspension was obtained. This was stirred under cooling with ice for 3 hours, and the solid was collected by filtration and washed with water (50 mL) to obtain a pale yellow crude product. The obtained crude product was subjected to an operation of washing with water (50 mL) with stirring and collection by filtration twice, followed by drying under reduced pressure to obtain 4-isothiocyanatobenzoic acid as a pale yellow solid (6.23 g, yield: 95%, HPLC purity: 100.0%).1H-NMR (DMSO-d6) delta: 7.52 (d, J=8.7 Hz, 2H), 7.97 (d, J=8.7 Hz, 2H), 13.20 (brs, 1H).

The synthetic route of 6160-65-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NISSAN CHEMICAL INDUSTRIES, LTD.; Takada, Junko; Iwamoto, Shunsuke; Nakano, Satoshi; US2013/245305; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem