Category: 6160-65-2

Related Products of 6160-65-2,Some common heterocyclic compound, 6160-65-2, name is 1,1′-Thiocarbonyldiimidazole, molecular formula is C7H6N4S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 19 (0.1 g, 0.36 mmol),1,1′-thiocarbonyldiimidazole (0.1 g, 0.58 mmol)And triethylamine (0.08 mL)Was dissolved in 30 mL of tetrahydrofuran,60 reflux 5h (TLC detection reaction is completed).After the reaction was completed, the solvent was evaporated under reduced pressure. To the residue was added 30 mL of dichloromethane and a saturated aqueous solution of sodium chloride (3×10 mL). The organic layer was dried over anhydrous sodium sulfate and filtered. (4-cyclopropyl-1-naphthyl) -2-mercapto-1H-imidazo [4,5-b] pyridine (22) as a yellowish solid. Yield 70.9%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1′-Thiocarbonyldiimidazole, its application will become more common.

Reference:
Patent; Shan Dong University; Lu, Xinyong; Meng, Qing; Zhan, Peng; Fang, Zengjun; Zhao, Tong; Sun, Zhuosen; Sun, Xiukun; (36 pag.)CN106083847; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 6160-65-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6160-65-2, name is 1,1′-Thiocarbonyldiimidazole, This compound has unique chemical properties. The synthetic route is as follows.

After performing this reaction several times, all product fractions were pooled and the resulting residue of the dihydroxyl derivative (124 mg, 269 mumol, 1 eq.) was dissolved under argon in tetrahydrofurane (80 mL) in a 250 mL flame-dried flask. To this solution was added thiocarbonyl diimidazole (480 mg, 2.69 mmol, 10 eq.) and 4-(dimethylamino)pyridine (329 mg, 2.69 mmol, 10 eq.). The resulting reaction mixture was heated to 80C and stirred at this temperature overnight. After cooling to room temperature, a small portion of silica gel was added and the solvent was removed under reduced pressure. The adsorbed crude product was purified by flash column chromatography (50% ethyl acetate in cyclohexane) to yield 119 mg (237 mumol, 88%) of (VII) as a colorless solid.

The chemical industry reduces the impact on the environment during synthesis 1,1′-Thiocarbonyldiimidazole. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.; EP2210881; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 6160-65-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6160-65-2, name is 1,1′-Thiocarbonyldiimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

In acetonitrile (10 mL) solution of 2-aminothiazole (1.00 g, 9.99 mmol) 1,1′-thiocarbonyl diimidazole (1.78 g, 9.99 mmol) was added under room temperature and argon gas atmosphere, and stirred at 40 degrees C for 2 hours (it became suspension). The residues were collected after settling reaction mixture at 5 degree C for several hours. filtered, washed and dried in vacuum with cold acetonitrile and then hexane to obtain title compound (a light yellow solid, 1.37 g, 6.49 mmol, 65%).

The synthetic route of 1,1′-Thiocarbonyldiimidazole has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6160-65-2, name is 1,1′-Thiocarbonyldiimidazole, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H6N4S

To a stirred solution of 6.8 g (35.0 mmol) of (5) in 150 mL of CH2Cl2 at RT was added 6.4g(35mmol) of l .l’-thiocarbonyldiimidazole. The mixture was stirred at room temperature for 15 minutes and then evaporated under reduced pressure and the residue was passed through a short pad of silica gel, eluting with a gradient of hexane/EtOAc, which gave (5-Isothiocyanato-2-methoxy- phenyl)-methyl-propyl-amine (6) (7.85g, 95%) as a colorless oil.

According to the analysis of related databases, 6160-65-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SYNTA PHARMACEUTICALS CORP.; WO2007/140002; (2007); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6160-65-2, name is 1,1′-Thiocarbonyldiimidazole, A new synthetic method of this compound is introduced below., COA of Formula: C7H6N4S

To a stirred solution of 6.8 g (35.0 mmol) of (5) in 150 mL Of CH2Cl2 at RT was added 6.4g (35mmol) of l,l ‘-thiocarbonyldiimidazole. The mixture was stirred at room temperature for 15 minutes and then evaporated under reduced pressure and the residue was passed through a short pad of silica gel, eluting with a gradient of hexane/EtOAc, which gave (5-Isothiocyanato-2-methoxy-phenyl)-methyl-propyl-amine (6) (7.85g, 95%) as a colorless oil.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SYNTA PHARMACEUTICALS CORP.; WO2008/57246; (2008); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 6160-65-2,Some common heterocyclic compound, 6160-65-2, name is 1,1′-Thiocarbonyldiimidazole, molecular formula is C7H6N4S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under the protection of argon, the cross spore alkali (1.86 g, 4.0 mmol) for 100 ml dichloromethane dissolved, at room temperature by adding 10 ml triethylamine andN,N’ – Sulfur carbonyl diimidazole (1.3 g, 8.0 mmol), the reaction overnight at room temperature. The reaction solution is poured into 100 ml ice water, dichloromethane extraction, anhydrous sodium sulfate after drying the organic phase concentration, silica gel column chromatography separation, dichloromethane: methanol=20:1 (v/v) elute and get the 3′ -N- (1 – Imidazole sulfur on behalf of the carboxamido) cross spore alkali 1.9 g, yield 82%,

The synthetic route of 6160-65-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guizhou Chinese Academy Of Sciences Natural Result Chemical Emphasis Experiment Shi (Guizhou Medical University Natural Result Chemical Emphasis Experiment Shi); Wang Liping; Zhu Weiming; Li Mingpeng; Xu Yanchao; Zuo Mingxing; (25 pag.)CN109879888; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 6160-65-2, A common heterocyclic compound, 6160-65-2, name is 1,1′-Thiocarbonyldiimidazole, molecular formula is C7H6N4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A: N-(thiazol-2-yl)-1H-imidazole-1-carbothioamide To thiazol-2-amine (2.12 g, 21.17 mmol) in acetonitrile (30 mL) and tetrahydrofuran (5 mL) was added di(lH-imidazol-l-yl)methanethione (4.90 g, 27.5 mmol). The reaction was stirred at 60 C for 5 hours. The reaction was cooled to room temperature and the precipitate was filtered and washed with cold acetonitrile (2 x 15 mL) to afford an orange-brown powder. The product, N-(thiazol-2-yl)-lH- imidazole- l-carbothioamide (3.70 g, 17.60 mmol, 83 % yield), was taken directly to the next step without any further characterization.

The synthetic route of 6160-65-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; COOK II, James H.; MCDONALD, Ivar, M.; KING, Dalton; OLSON, Richard, E.; WANG, Nenghui; IWUAGWU, Christiana, I.; ZUSI, Christopher, F.; MACOR, John, E.; WO2011/53292; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 6160-65-2, These common heterocyclic compound, 6160-65-2, name is 1,1′-Thiocarbonyldiimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A flask was charged with (8S,10R,llS,12S,13R,14S)-12-hydroxy-ll-(4- methoxyphenyl)- 10,13 -dimethy 1-2, 6,7, 8,9, 11,12,14,15,16-decahy dro- 1 H- cyclopenta[a]phenanthrene-3,17-dione (Step H) (270 mg, 0.66mmol) and azeotroped with toluene. DCM (7 mL) was added, followed by triethylamine (0.28mL, 1.98mmol, 3 eq), and di(imidazol-l-yl)methanethione (1.18 g, 6.61mmol, 10 eq). The reaction was stirred under argon at rt for one day, then another portion of di(imidazol-l-yl)methanethione (1.1 g) was added. After another day, another 700 mg of di(imidazol-l-yl)methanethione was added. The reaction was stirred for 2 more days. Then the reaction was quenched with diluted HCl (chromatography to give the title compound (265 mg, 77%). m/z (ESI, +ve ion) 541.3 (M+Na)+.

Statistics shows that 1,1′-Thiocarbonyldiimidazole is playing an increasingly important role. we look forward to future research findings about 6160-65-2.

Reference:
Patent; ORIC PHARMACEUTICALS, INC.; SUN, Daqing; MCGEE, Lawrence R.; DU, Xiaohui; ZHU, Liusheng; YAN, Xuelei; REW, Yosup; EKSTEROWICZ, John; MEDINA, Julio C.; ZHOU, Haiying; BALBAS, Minna Delarae; FANTIN, Valeria R.; (98 pag.)WO2017/112909; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 6160-65-2, name is 1,1′-Thiocarbonyldiimidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6160-65-2, Product Details of 6160-65-2

A solution of the amine (0.1 10 g, 0.43 mmol) in anhydrous CH2CI2 (2 mL) was added dropwise over 2-5 minutes to an ice-salt bath cooled solution of 1 , 1 ‘-thiocarbonyldiimidazole (95%, 0.162 g, 0.87 mmol, 2 eq.) in anhydrous CH2CI2 (6 mL). After 15 minutes, the cooling bath was removed and the reaction mixture was stirred at room temperature for 1 .5 hours after which time analysis by TLC (10% MeOH in CH2CI2) indicated complete consumption of the starting aniline. The mixture was cooled once again in an ice bath and 7 M NH3 in MeOH (620 muIota_, 4.3 mmol, 10 eq.) was added dropwise over 2-5 minutes. The bath was removed and the mixture was stirred over night at room temperature. Silica gel (~1 g) was added and the mixture was concentrated to dryness under reduce pressure. Flash column chromatography (RediSepRf Si02 (40 g), 100% CH2CI2? 10% MeOH in CH2CI2) gave the thiourea as an amber oil that solidified upon standing (0.130 g, 97%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,1’-Thiocarbonyldiimidazole, and friends who are interested can also refer to it.

Reference:
Patent; DUKE UNIVERSITY; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; LIEDTKE, Wolfgang; STEINHOFF, Martin; GUILAK, Farshid; (150 pag.)WO2016/28325; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 6160-65-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6160-65-2 as follows.

At 0C, a solution of 1,1′-thiocarbonyldiimidazole (206 mg, 1.10 mmol) in DCM (3 mL) was added dropwise 4-(3-aminophenyl)piperidine-1-carboxylic acid tert-butyl ester (160 mg, 0.58 mmol) in DCM (2 mL) and the mixture was stirred at room temperature for 3 hours. The reaction mixture was cooled again to 0C and a solution of ammonia in MeOH 7N (2 mL) was added dropwise. The reaction mixture was stirred at room temperature for 16 hours. Water was added and extracted with DCM. Purification by flash chromatography (silica gel, gradient to hexanes to 50% acetone). The desired product was obtained as a white foam (180 mg, 93% yield).

According to the analysis of related databases, 6160-65-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S. A.; CUEVAS CORDOBES, FELIX; ALMANSA ROSALES, CARMEN; GARCIA LOPEZ, MONICA; (299 pag.)TW2016/27300; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem