Category: 616-47-7

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 616-47-7, Name is 1-Methyl-1H-imidazole, molecular formula is , belongs to imidazoles-derivatives compound. In a document, author is Pilawka, Ryszard, Recommanded Product: 616-47-7.

High-performance isocyanate-epoxy materials

Purpose – The purpose of this paper is to investigate a new group of chemical compounds as accelerators (1-imidazole derivatives – tertiary amines) for curing of isocyanate-epoxy resin matrix. During heating no reaction between epoxy group and active hydrogen in presence 1-substituted imidazole derivatives was reported. Design/methodology/approach – The influence of accelerator type and content on curing process, thermal stability and chemical structure of hardened resin was determined using temperature modulated differential scanning calorimetry, dynamic mechanical analysis, heat deflection temperature, thermogravimetry (modulated and by activation energy – Ozawa method) and Fourier transform infrared spectroscopy. Additionally, the shear strength of epoxy compositions used as aluminium joints, at ambient and elevated temperature was determined. Findings – With catalyst content increase the oxazolidone or isocyanurate rings content decreased, indicating enhanced density of cross-linking and thermal resistance. For all imidazole derivatives used (i.e. 1-methylimizadole, 1-ethylimidazole and 1-butylimidazole) accelerating of the curing process was observed (significant decrease of the curing start temperature was reported). The thermal resistance and shear strength was improved with accelerator content (increase of isocyanurate rings amount, and consequently oxazolidone ones). Originality/value – Introducing of a new group of chemical compounds as new catalysts to isocyanate-epoxy resin material resulted in curing process acceleration, irrespectively of the imidazole derivative type.

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Electric Literature of 616-47-7, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 616-47-7, Name is 1-Methyl-1H-imidazole, SMILES is CN1C=CN=C1, belongs to imidazoles-derivatives compound. In a article, author is Sun, Sijuan, introduce new discover of the category.

Determination of Three Imidazole Derivatives by Flow-Injection Chemiluminescence

A rapid, simple, and sensitive method was developed for the determination of three imidazole derivatives based on their quenching effect on bis(2,4,6-tricholorophenyl) oxalate (TCPO)-H2O2 chemiluminescence (CL) in the presence of rhodamine 6G. Conditions affecting CL intensity were studied. With sodium dodecyl sulfate (SDS) as the additional agent, the relative standard deviation (RSD) was more twice the RSD without SDS. Under optimal conditions, good linear ranges were obtained from 1.0×10-4g/mL to 1.0×10-6g/mL, 1.0×10-5g/mL to 1.0×10-7g/mL, and 1.0×10-5g/mL to 7.0×10-7g/mL, with detection limits of 8.0×10-7g/mL, 7.0×10-8g/mL, and 8.0×10-8g/mL (S/N=3) for hydrobenzole hydrochloride, thiamazole, and mizolastine, respectively. The RSDs for 13 consecutive injections of 1.0×10-6g/mL hydrobenzole hydrochloride, thiamazole, and mizolastine were 1.89%, 1.47%, and 1.69%, respectively, and satisfied results were obtained with the method applied to their pharmaceutical preparations. The possible CL mechanism was simply discussed.

Electric Literature of 616-47-7, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 616-47-7 is helpful to your research.

In an article, author is Singh, Ambrish, once mentioned the application of 616-47-7, Name is 1-Methyl-1H-imidazole, molecular formula is C4H6N2, molecular weight is 82.1, MDL number is MFCD00005292, category is imidazoles-derivatives. Now introduce a scientific discovery about this category, Computed Properties of C4H6N2.

Electrochemical, surface and quantum chemical studies of novel imidazole derivatives as corrosion inhibitors for J55 steel in sweet corrosive environment

The corrosion inhibition performance of three novel imidazole derivatives namely 2-(4-methoxyphenyl)4,5-diphenyl-imidazole (M-1), 4,5-diphenyl-2-(p-tolyl)-imidazole (M-2) and 2-(4-nitrophenyl)-4,5-diphenyl-imidazole (M-3) for J55 steel in CO2 saturated brine solution was studied by weight loss method, electrochemical impedance spectroscopy (EIS), potentiodynamic polarization, scanning electrochemical microscopy (SECM), contact angle, scanning electron microscope (SEM), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS) and quantum chemical calculation. M-1 exhibited the best inhibition efficiency of 93% at 400 mg/L concentration. The adsorption of the imidazole derivatives obeyed the Langmuir adsorption isotherm. Contact angle measurement reveals the hydrophobic nature of J55 steel in presence of inhibitors. Quantum chemical calculation well supports the experimental results. (C) 2017 Elsevier B.V. All rights reserved.

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In an article, author is lauro, Figueroa-Valverde, once mentioned the application of 616-47-7, Name is 1-Methyl-1H-imidazole, molecular formula is C4H6N2, molecular weight is 82.1, MDL number is MFCD00005292, category is imidazoles-derivatives. Now introduce a scientific discovery about this category, Recommanded Product: 616-47-7.

Synthesis and biological activity of two oxireno-azecin-imidazole derivatives on perfusion pressure via guanylate cyclase inhibition

Some drugs have used in the treatment of heart failure; however, several of these drugs can produce secondary effects such as arrhythmia, hypotension and others. Therefore, the objective of this study was to synthesize two oxireno-azecin-imidazole derivatives (compounds 13 and 14) from two estradiol and estrone analogs through a series of reactions which involving; a) addition; b) acetylation; c) epoxidation; d) formation of two azecine derivatives; e) removal of silyl fragment of the azecines with hydrofluoric acid. Additionally, these compounds were confirmed by NMR spectroscopic data. Then, biological activity of the oxireno-diazepam-imidazole derivatives against perfusion pressure was evaluate in an isolated rat heart model, using the BAY-41-2272 (guanylate cyclase agonist), NS-2028 (guanylate cyclase inhibitor) and nifedipine (calcium channel antagonist) as controls. The results indicate that compounds 13 and 14 increased the perfusion pressure in the absence or presence of BAY-41-2272 and NS-2028; however, this effect was inhibited by nifedipine. These data indicate that compounds 13 and 14 could have a dual effect on perfusion pressure through guanylate cyclase inhibition and calcium channel type-L activation.

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Reference of 616-47-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 616-47-7, Name is 1-Methyl-1H-imidazole, SMILES is CN1C=CN=C1, belongs to imidazoles-derivatives compound. In a article, author is Wnuk, Malgorzata, introduce new discover of the category.

Prediction of antimicrobial activity of imidazole derivatives by artificial neural networks

The main goal of our study is the analysis of data obtained from molecular modeling for a series of imidazole derivatives that possess strong antifungal activity. The research was designed to use artificial neural network (ANN) analysis to determine quantitative relationships between the structural parameters and anti-Streptococcus pyogenes activity of a series of imidazole derivatives. ANN in association with quantitative structure-activity relationships (QSAR) represents a promising tool in the search for drug candidates among the practically unlimited number of possible derivatives. In this work, a series of 286 imidazole derivatives presented as cationic three-dimensional structures was used. The activity was expressed as a logarithm of the reciprocal of the minimal inhibitory concentrations, log 1/MIC. Multilayer perceptron ANN was used for predictions of antimicrobial potency of new imidazole derivatives on the basis of their structural descriptors. The obtained correlation coefficient equaled 0.9461 for the learning set, 0.9060 for the validation set and 0.8824 for the testing set of imidazole derivatives. Hence, satisfactory and practically useful predictions of anti-Streptococcus pyogenes activity for a series of imidazole derivatives was obtained, supporting the future successful interpretation of QSAR analysis for those compounds.

Reference of 616-47-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 616-47-7 is helpful to your research.

616-47-7, Name is 1-Methyl-1H-imidazole, molecular formula is C4H6N2, Name: 1-Methyl-1H-imidazole, belongs to imidazoles-derivatives compound, is a common compound. In a patnet, author is Gulevich, Anton V., once mentioned the new application about 616-47-7.

The first example of a diastereoselective thio-Ugi reaction: A new synthetic approach to chiral imidazole derivatives

The first example of a diastereoselective thio-Ugi reaction with chiral a-methylbenzylamine is described. The reaction results in formation of two diastereomers of thioamides, the major of which was isolated. We have found that under similar conditions stereochemical results of the thio-Ugi reaction are opposite to stereochemical results of the Ugi reaction. Several chiral thioamides were synthesized. The reaction of thioamides with ammonia results in substituted amidines, which can be cyclized to imidazole derivatives in aqueous HC1. The synthesis of chiral imidazole derivatives was elaborated. Using certain approaches, both isomers of a key synthon in the synthesis of SB203386 (an orally bioactive HIV-1 protease inhibitor) were prepared. The scope, limitations, and stereochemistry of the approach are discussed.

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Synthetic Route of 616-47-7, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 616-47-7, Name is 1-Methyl-1H-imidazole, SMILES is CN1C=CN=C1, belongs to imidazoles-derivatives compound. In a article, author is Mariappan, G., introduce new discover of the category.

Design, synthesis and neuropharmacological activity of dihydro imidazole derivatives

A new series of dihydro imidazole derivatives have been synthesized and characterized by UV-Vis, IR, H-1 NMR and mass spectroscopy. The synthesized compounds have been screened for neuro pharmacological activities. All the compounds are effective; amongst them compound 8 shows more prominent anticonvulsant and CNS depressant property. The standard drug diazepam at 25 mg / kg i.p. has been used for comparison. The results are statistically treated for their significance at p<0.05 and p<0.01 level. Synthetic Route of 616-47-7, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 616-47-7 is helpful to your research.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 616-47-7, name is 1-Methyl-1H-imidazole, A new synthetic method of this compound is introduced below., name: 1-Methyl-1H-imidazole

General procedure: [BSTMG][HSO4]: 1,1,3,3-tetramethylguanidine (0.2 mol) and 1,4-butane sultone (0.2 mol) were charged into a 250 mL round bottom flask equipped with a reflux condenser. Then the mixtures were stirred at 353 K for 7 h. The obtained white solid zwitterion was washed several times with toluene to remove non-ionic residues and dried in vacuum. After that, a stoichiometric amount of sulphuric acid (0.2 mol) was added dropwise and the mixture was stirred for 10 h at 343 K. A kind of viscous ionic liquid phase was obtained and was washed by ether for several times. The ionic liquid was dried in vacuum for 2 h. The ionic liquids [BSTMG][CF3SO3], [BSTMG][CF3CO2], [BSPy][HSO4], [BSIMI][HSO4]and [BSEt3N][HSO4] were prepared by the same procedure.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Wu, Li; Li, Zhen; Wang, Fang; Lei, Min; Chen, Jing; Journal of Molecular Catalysis A: Chemical; vol. 379; (2013); p. 86 – 93;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 616-47-7, These common heterocyclic compound, 616-47-7, name is 1-Methyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A literature procedure for the synthesis of the title compound was adopted. 2 A solution of N-methyl-1H-imidazole (280 muL, 290 mg, 3.50 mmol) in anhydrous THF (7 mL) was cooled to -78C and n-BuLi (2.5 M in hexanes, 2.2 mL, 3.60 mmol) was added dropwise by syringe under stirring. The resulting yellow solution was stirred for 30 minutes at -78C where upon chlorotrimethylsilane (465 muL, 399 mg, 3.67 mmol) was added dropwise by syringe; after the addition the resulting reaction mixture was allowed to return to room temperature and the stirring was continued for 1 h. The reaction was then cooled back to -78C, ethylchloroformiate (350 muL, 398 mg, 3.67 mmol) was added and the resulting mixture was allowed to warm up to room temperature and further stirred for 1h. The reaction was quenched with water (1 mL) and the solvents were evaporated under reduced pressure. The obtained crude product was dissolved in dichloromethane (100 mL), washed with water (3 x25 mL) and brine (1 x 25 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel with EtOAc as eluent, the chromatographic fractions containing the required compound were collected and concentrated under reduced pressure, affording the title compound 1f as a colorless liquid(152 mg, 37%).

Statistics shows that 1-Methyl-1H-imidazole is playing an increasingly important role. we look forward to future research findings about 616-47-7.

Reference:
Article; Bellina, Fabio; Lessi, Marco; Marianetti, Giulia; Panattoni, Alessandro; Tetrahedron Letters; vol. 56; 25; (2015); p. 3855 – 3857;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 616-47-7, name is 1-Methyl-1H-imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 616-47-7

General procedure: n-BuLi (1.67 M solution in hexane, 1.32 mL, 2.2 mmol) was added dropwise into a solution of p-bromochlorobenzene (383 mg, 2.0 mmol) in THF (3 mL) at -78 C for 30 min. Then, ethyl formate (1.6 mL, 20 mmol) was added to the mixture and the obtained mixture was stirred at -78 C. After 3 h at the same temperature, I2 (1523 mg, 6 mmol), K2CO3 (1382 mg, 10 mmol) and EtOH (3 mL) were added at -78 C and the mixture was stirred for 14 h at rt. The reaction mixture was quenched with satd aq Na2SO3 (5 mL) and was extracted with CHCl3 (3¡Á20 mL). The organic layer was washed with brine and dried over Na2SO4 to provide ethyl 4-chlorobenzoate in 77% yield. If necessary, the product was purified by short column chromatography (SiO2:hexane:EtOAc=9:1) to give pure ethyl 4-chloro-1-benzoate as a colorless oil.

The synthetic route of 616-47-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ushijima, Sousuke; Moriyama, Katsuhiko; Togo, Hideo; Tetrahedron; vol. 68; 24; (2012); p. 4701 – 4709;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem