Category: 616-47-7

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 616-47-7 as follows. HPLC of Formula: C4H6N2

(Reference Example 9) Synthesis of ethyl 1-methyl-1H-imidazole-2-carboxylate: Triethylamine (3.40 mL, 24.4 mmol) and ethyl chloroformate (2.34 mL, 24.4 mmol) were added to a solution of 1-methyl-1H-imidazole (1.00 g, 12.2 mmol) in acetonitrile (4.0 mL) at 0C and the reaction liquid was stirred at room temperature for 16 hours. The reaction liquid was filtered through Celite and the filtrate was concentrated under reduced pressure. The residue was purified by flash column chromatography (silica gel, hexane/ethyl acetate) to obtain ethyl 1-methyl-1H-imidazole-2-carboxylate (1.50 g, 9.73 mmol, 80%) as a white solid. 1H-NMR (400 MHz, CDCl3) delta: 1.42 (3H, t, J=7.2 Hz), 4.01 (3H, s), 4.40 (2H, q, J=7.2 Hz), 7.01-7.03 (1H, m), 7.13-7.15 (1H, m). ESI-MS: m/z= 155 (M+H)+.

According to the analysis of related databases, 616-47-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Toray Industries, Inc.; ARAI Tadamasa; MORITA Yasuhiro; UDAGAWA Shuji; ISEKI Katsuhiko; IZUMIMOTO Naoki; (95 pag.)EP3263565; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 616-47-7, name is 1-Methyl-1H-imidazole, A new synthetic method of this compound is introduced below., Quality Control of 1-Methyl-1H-imidazole

1-methylimidazole (1 mmol, 82.1 mg),Perfluoro iodobutane (3.1 mmol, 1072 mg) was placed in a 10 mL round bottom flask.Potassium tert-butoxide (2.2 mmol, 246.9 mg) was addedAnd 5mL of toluene, stirring at room temperature for 3 hours,TLC monitored the endpoint of the reaction.After the toluene was removed by rotary evaporation, the mixture was washed with water and extracted with dichloromethane. The organic phase was collected and dried. The dichloromethane was removed by rotary evaporation to give a crude product.The crude product was subjected to silica gel column chromatography with petroleum ether and ethyl acetate as eluents (ratio by volume = 15:1).The product 1 was obtained: 2-iodo-1-methylimidazole (white solid, 72 mg, 35%).Product 2: 2,5-diiodo-1-methylimidazole (white solid, 210 mg, 63%)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Liaoning University; Liang Fushun; Liu Xia; Han Zhengbo; Su Zhongmin; (10 pag.)CN107501023; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 616-47-7,Some common heterocyclic compound, 616-47-7, name is 1-Methyl-1H-imidazole, molecular formula is C4H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Triethylamine (3.40 mL, 24.4 mmol) and Ethyl chloroformate (2.34 mL, 24.4 mmol) were added at 0 C. to an acetonitrile (4.0 mL) solution of 1-methyl-1H-imidazole (1.00 g, 12.2 mmol), and the reaction solution was stirred at room temperature for 16 hours. The reaction solution was filtered through celite, and the filtrate was concentrated under reduced pressure. The residue was purified by flash column chromatography (silica gel, hexane/ethyl acetate), thereby obtaining ethyl 1-methyl-1H-imidazole-2-carboxylate (1.50 g, 9.73 mmol, 80%) as a white solid.1H-NMR (400 MHz, CDCl3) delta: 1.42 (3H, t, J=7.2 Hz), 4.01 (3H, s), 4.40 (2H, q, J=7.2 Hz), 7.01-7.03 (1H, m), 7.13-7.15 (1H, m)ESI-MS: m/z=155 (M+H)+

The synthetic route of 616-47-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Toray Industries, Inc.; Takahashi, Hirozumi; Baba, Yoko; Morita, Yasuhiro; Iseki, Katsuhiko; Izumimoto, Naoki; (19 pag.)US2020/172507; (2020); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 616-47-7, name is 1-Methyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 1-Methyl-1H-imidazole

D preparation of ionic liquid: in the flask to three N-methyl imidazole, slowly dropping equimolar 1, 4-propane sulfur lactone, stirring, reaction 24h, filtered, to obtain white precipitation, washing by acetone, vacuum drying to obtain intermediate; then the intermediate in adding three-mouth flask, dropping equimolar concentrated sulfuric acid, with ethyl acetate as the solvent, the temperature is increased to 70 C reflux reaction mixing 48h, then ethyl acetate for washing, d vacuum drying to obtain the ionic liquid.

The synthetic route of 616-47-7 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 616-47-7, name is 1-Methyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 616-47-7, name: 1-Methyl-1H-imidazole

(Comparative Examples 1 to 4) 1-methyl-1H-imidazole 3.3 g scaleAfter replacing the inside of a 100 mL three-necked flask with an argon atmosphere, 22 mL of acetonitrile, 3.3 g of 1-methyl-1H-imidazole and triethylamine in the amounts shown in Table 1 were added and cooled to -20 C. To this solution, a solution of ethyl chloroformate in the amount shown in Table 1 in 8 mL of acetonitrile was added at the addition time shown in Table 1. Thereafter, the mixture was stirred at room temperature for the reaction time shown in Table 1. To the reaction solution were added 20 mL of ethanol and 10 mL of water to dissolve the precipitate, and 1 mL was collected from the homogenized solution. The collected solution was diluted 1000-fold with acetonitrile and subjected to HPLC analysis, and the yield was calculated. The results are shown in Table 2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-imidazole, and friends who are interested can also refer to it.

616-47-7, name is 1-Methyl-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1-Methyl-1H-imidazole

After replacing the inside of a 100 mL three-necked flask with an argon atmosphere, 22 mL of acetonitrile and 6.3 mL of methyl chloroformate were added and the mixture was cooled to -20 C. To this solution, a solution of 3.3 g of 1-methyl-1H-imidazole and 6.8 mL of triethylamine in 8 mL of acetonitrile was added in 30 minutes, followed by stirring at room temperature for 12 hours. After adding 50 mL of ethyl acetate to the reaction solution, insoluble matter was filtered off, and the residue was washed with 50 mL of ethyl acetate. The filtrate and the washing solution were combined, concentrated under reduced pressure,the concentrated residue was purified by column chromatography(Silica gel, hexane / ethyl acetate) to obtain 4.2 g (yield: 73%) of methyl 1-methyl-1H-imidazole-2-carboxylate.

The synthetic route of 616-47-7 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 616-47-7 as follows. Quality Control of 1-Methyl-1H-imidazole

In a 100-mL round bottom flask, a mixture of 1-methyl imidazole (0.1 mol, 8.21 g) and 1,4-butane sultone (0.1 mol, 11 mL) in toluene (30 mL) was refluxed for 24 h. The obtained white solid was washed with toluene (2910 mL) and dried under reduced pressure. Then, a stoichiometric amount of concentrated sulfuric acid (98 %) was added to the solid and the mixture was stirred for 24 h at 70 C to form the DAIL. It was then washed with diethyl ether (2*10 mL) and dried under vacuum.

According to the analysis of related databases, 616-47-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Rostamizadeh, Shahnaz; Zekri, Negar; Research on Chemical Intermediates; vol. 42; 3; (2016); p. 2329 – 2341;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Parab, R. H., once mentioned the application of 616-47-7, Name is 1-Methyl-1H-imidazole, molecular formula is C4H6N2, molecular weight is 82.1, MDL number is MFCD00005292, category is imidazoles-derivatives. Now introduce a scientific discovery about this category, Safety of 1-Methyl-1H-imidazole.

Synthesis, Characterization and Antimicrobial Activity of Imidazole Derivatives

A series of oxazole and their imidazole derivatives were prepared from 6-bromo-2-chloro-3-formylquinoline. The structures of all the synthesized compounds were elucidated by elemental, IR, H-1 NMR, C-13 NMR spectra. They were assayed in vitro for their antimicrobial activity. It was revealed that some synthesized derivatives show remarkable biological activity against both gram-negative and gram, positive bacterial species and fungal microorganisms.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 616-47-7, Safety of 1-Methyl-1H-imidazole.

Application of 616-47-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 616-47-7, Name is 1-Methyl-1H-imidazole, SMILES is CN1C=CN=C1, belongs to imidazoles-derivatives compound. In a article, author is Kuhn, N, introduce new discover of the category.

Imidazole derivative .24. [Li12O2Cl2(ImN)(8)(THF)(4)]center dot 8THF: A peroxo lithium fragment in a novel cage structure

1,3-dimethyl-2-iminoimidazoline (8, ImNH) reacts with methyl lithium to give [ImNLi](n) (9). In tetrahydrofuran, crystals of C56H96Cl2Li12N24O6 . 8C(4)H(8)O (10) are obtained. The structure of 10 consists of a Li12Cl2N8O2 core in which a peroxo unit is incorporated into a stack of ladder fragments. Over all, four tetrahydrofuran and eight imidazoline ligands are attached at the lithium and nitrogen atoms.

Application of 616-47-7, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 616-47-7.

In an article, author is Ogretir, C, once mentioned the application of 616-47-7, Recommanded Product: 616-47-7, Name is 1-Methyl-1H-imidazole, molecular formula is C4H6N2, molecular weight is 82.1, MDL number is MFCD00005292, category is imidazoles-derivatives. Now introduce a scientific discovery about this category.

Spectroscopic determination of acid dissociation constants of some imidazole derivatives

The acid dissociation constants, pK(a), of eight biologically active imidazole derivatives were determined using a spectroscopic technique. Using the obtained acid dissociation constants, attempts were made to elucidate the structures and protonation mechanisms of these derivatives. Four of eight molecules were found to behave as Hammett base for the first protonation.

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