Reference of 616-47-7, A common heterocyclic compound, 616-47-7, name is 1-Methyl-1H-imidazole, molecular formula is C4H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The ionic liquids used in this study (Fig. 1) were synthesized as described in the literature [23,24]. IL-1, for example, was prepared as follows: 1-methylimidazole (16.4g, 0.2mol) and 1, 4-butanesultone (27.28g, 0.2mol) were mixed in a 100mL round bottom flask. The mixture was stirred at 42-45C for 17h. The white solid zwitterion was washed repeatedly with ether to remove non-ionic residues, filtrated through a Buchner funnel, and dried in vacuum for 4h. A stoichiometric amount of trifluoroacetic acid (22.8g, 0.2mol) was added dropwise, and the mixture was stirred for 6h at 80C. The viscous liquid was washed three times with ether and dried in vacuum to form IL-1.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Tao, Fu-Rong; Zhuang, Chen; Cui, Yue-Zhi; Xu, Jing; Chinese Chemical Letters; vol. 25; 5; (2014); p. 757 – 761;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem