Category: 615-16-7

Electric Literature of 615-16-7,Some common heterocyclic compound, 615-16-7, name is 2-Hydroxybenzimidazole, molecular formula is C7H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a three flask equipped with a thermometer dichloroethane solvent 1000ml, added slowly with stirring 268gBenzimidazolone. Meanwhile weighed 305g of fuming nitric acid (concentration ?95%), and slowly poured three bottles, while down while stirring. Then added phosphorus pentoxide 20g. Reflux, the reaction temperature is 85 , TLC tracking dinitro compound detected is generated to stop the reaction. While recovering the solvent was concentrated under reduced pressure, water was added, extraction dichloroethane, and the solvent was evaporated to dryness to give the product recovered organic phase was dried over anhydrous sodium sulfate. 381g dried to give a solid, a yield of 85.1%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Hydroxybenzimidazole, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 615-16-7, name is 2-Hydroxybenzimidazole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2-Hydroxybenzimidazole

General procedure: Hydantoin 10 (0.10 g, 1.00 mmol) was dissolved in dry pyridine (10 mL) and DMAP (0.13 g, 1.10 mmol) was added, followed by hexyl isocyanate (0.15 mL, 1.00 mmol). The resulting solution was stirred under nitrogen atmosphere at rt for 12 h. The solvent was evaporated under reduced pressure and the crude was purified by silica gel column chromatography (cyclohexane/EtOAc 70:30) to afford 15 (0.05 g, 20%) as a white powder.

According to the analysis of related databases, 615-16-7, the application of this compound in the production field has become more and more popular.

Related Products of 615-16-7, These common heterocyclic compound, 615-16-7, name is 2-Hydroxybenzimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of 4a or 4b (1 equiv.) and K2CO3 (3 equiv.) in DMF was stirred at 90C for 1h, then the solution was allowed to cool to 60C and was added different substituted 2-chloro-1-phenylethan-1-one (3 equiv.). The mixture was stirred at 60C for another 3h and allowed to cool to room temperature. The saturated NH4Cl solution was added to quench the reaction. The mixture was diluted with water and was extracted with ethyl acetate to afford the crude product that was purified by flash column chromatography on silica gel to yield the target products

The synthetic route of 615-16-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zou, Yi; Wang, Yan; Wang, Fang; Luo, Minghao; Li, Yuezhen; Liu, Wen; Huang, Zhangjian; Zhang, Yihua; Guo, Wenjie; Xu, Qiang; Lai, Yisheng; European Journal of Medicinal Chemistry; vol. 138; (2017); p. 199 – 211;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 615-16-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 615-16-7 name is 2-Hydroxybenzimidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 23; Preparation of 3-((2-(l,3-dimethyl-2-oxu-2)3-dihydro-l//-benzimidazol-5-yl)-2- oxoethyl)tbio) propanoic acid (23); (i) l,3-Dimethyl-l,3-dihydro-2W-bcn7.iitauiidazol-2-onc; l,3-Dihydro-2H-benziiuida7;ol-2-one (7.522 g, 56.1 mmol) was dissolved in anhydrous DIvIF (125 oil) and anhydrous potassium carbonate (46.581 g, 337 mmol) and iodomethane (21 ml, 337 mmol) were added then the mixture stirred at room temperature overnight. The reaction mixture was poured into chloroform (500 ml), filtered and the filtrate was evaporated to dryness. The resultant residue was dissolved in a mixture of ethyl acetate (150 ml) and water (100 ml). The cthyi acetate phase was washed with water (2 x 100 ml) and brine ( 100 ml), dried over anhydrous magnesium sulfate and filtered. The filtrate was evaporated to dryness to give the title compound (7,229 g, 79% yield) as a pale yellow solid.1H nmr (400 MHz1 CDCl3) delta 3.43 (s, 6H); 6.95-7.01 (m, 2H); 7.08-7.14 (m, 211).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Hydroxybenzimidazole, and friends who are interested can also refer to it.

Reference:
Patent; CORTICAL PTY LTD; WO2007/70961; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem