Adding a certain compound to certain chemical reactions, such as: 611-09-6, name is 5-Nitroindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 611-09-6, COA of Formula: C8H4N2O4
A mixture of 5-nitroisatin 22a (5.0 g, 26.0 mmol), 2, 2′-dimethylpropane-1, 3-diol (2.69 g, 25.9 mmol) and a catalytic amount ofp-TSA was suspended in cyclohexane (35 mL) and refluxed with azeotropic removal of water using Dean-Stark apparatus, overnight. The reaction mixture was cooled to room temperature and the solid that separeted was filtered, washed with dilute aqueous sodium bicarbonate, water and then air dried to give 22b. Yield 6. 5g, 90%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Nitroindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE ROCKEFELLER UNIVERSITY; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; WO2005/41954; (2005); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem