Category: 60-56-0

60-56-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Add 1-methyl-2-mercaptoimidazole (0.23 g, 2.04 mmol) to a 150 mL round bottom flask.After stirring potassium carbonate as a base (0.30 g, 2.30 mmol) and acetonitrile as a solvent at 50 C for 40 minutes,After cooling to room temperature, intermediate V (0.43 g, 1.70 mmol) was added and the mixture was warmed to 75 C and the mixture was traced to the end of the reaction.After concentration, extraction, column chromatography separation, drying and the like, the intermediate VIII (0.34 g) is obtained in a yield of 54.2%;White solid,

The synthetic route of 1-Methyl-1H-imidazole-2(3H)-thione has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Southwest University; Zhou Chenghe; Man Nabaonei¡¤lamohan¡¤laao¡¤yadafu; Wang Juan; (39 pag.)CN110305064; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

60-56-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Complexes 1-4 were prepared in a Schlenk tubecontaining 30 mL of CH2Cl2 (deaerated previously).Then, 0.24 mmol of the ligand and 32 muL of triethylaminewas added to the Schlenk. Afterwards, 0.11 mmol of theprecursor [RuCl2(dppb)(PPh3)] was added and the solutionwas stirred for 12 h under Ar atmosphere. The final yellowsolutions were concentrated to about 2 mL and diethyl etherwas added, to obtain yellow precipitates. The solids werefltered off, well rinsed with water (5 ¡Á 5 mL) and diethylether (3 ¡Á 5 mL) and dried in vacuo.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Batista, Alzir A.; Castellano, Eduardo E.; Castelli, Silvia; Cominetti, Marcia R.; Deflon, Victor M.; Desideri, Alessandro; da Silva, Monize M.; de Camargo, Mariana S.; de Grandis, Rone A.; Journal of the Brazilian Chemical Society; vol. 31; 3; (2020); p. 536 – 549;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

60-56-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Complexes 1-4 were prepared in a Schlenk tubecontaining 30 mL of CH2Cl2 (deaerated previously).Then, 0.24 mmol of the ligand and 32 muL of triethylaminewas added to the Schlenk. Afterwards, 0.11 mmol of theprecursor [RuCl2(dppb)(PPh3)] was added and the solutionwas stirred for 12 h under Ar atmosphere. The final yellowsolutions were concentrated to about 2 mL and diethyl etherwas added, to obtain yellow precipitates. The solids werefltered off, well rinsed with water (5 ¡Á 5 mL) and diethylether (3 ¡Á 5 mL) and dried in vacuo.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Batista, Alzir A.; Castellano, Eduardo E.; Castelli, Silvia; Cominetti, Marcia R.; Deflon, Victor M.; Desideri, Alessandro; da Silva, Monize M.; de Camargo, Mariana S.; de Grandis, Rone A.; Journal of the Brazilian Chemical Society; vol. 31; 3; (2020); p. 536 – 549;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A common compound: 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, belongs to imidazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 60-56-0

[Cu(MeimzH)2(phen)(H2O)2]Cl2 (Cu-Met-phen) a solution was prepared by mixing 1 mmol (0.1142 g) of methimazole dissolved in 5 mL of water with 1 mmol (0.1802 g) of o-phenanthroline dissolved in 5 mL of ethanol. To this solution, 1 mmol (0.1705 g) of solid copper(II) chloride dihydrate was slowly added under continuous stirring. The resulting mixture was stirred at room temperature for 2 h. After that, a light green precipitate was formed which was separated, filtered and washed several times with ethanol. After this procedure it was dried in an oven at 60 C. Anal. Calc. for C20H24N6O2S2Cl2Cu: C, 41.48; H, 4.15; N, 14.52; S, 11.06. Found: C, 41.15; H, 4.27; N, 14.78; S, 11.38 %. Yield:75%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 60-56-0, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Urquiza, Nora M.; Islas, M. Soledad; Dittler, Maria Laura; Moyano, Maria A.; Manca, Silvia G.; Lezama, Luis; Rojo, Teofilo; Medina, Juan J. Martinez; Diez, Maximiliano; Tevez, Leonor Lopez; Williams, Patricia A.M.; Ferrer, Evelina G.; Inorganica Chimica Acta; vol. 405; (2013); p. 243 – 251;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 60-56-0

2-chlorosulfonyl-1-methylimidazole Bleach (12% w/w aq, 110 ml) was cautiously added dropwise to a solution of 2-mercapto-1-methylimidazole (2.0 g) in conc. H2SO4 (50 ml) cooled to 0 C. After stirring 30 minutes at 0 C. the mixture was diluted with H2O (30 ml) and dichloromethane (30 ml). The aqueous layer was re-extracted with dichloromethane and the combined organic layers dried (MgSO4) and evaporated to give the product as an oil (730 mg).

Statistics shows that 60-56-0 is playing an increasingly important role. we look forward to future research findings about 1-Methyl-1H-imidazole-2(3H)-thione.

Reference:
Patent; Lewis, Huw David; Harrison, Timothy; Shearman, Mark Steven; US2009/215775; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 60-56-0 name is 1-Methyl-1H-imidazole-2(3H)-thione, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 60-56-0

3-methoxy salicylaldehyde 5 (1 mmol), malononitrile 6 (2.2 mmol), 2-mercaptoimidazole 7 (1.2 mmol), compound4 (20 mol%) and ethanol (5 mL) were sequentially added to a 50 mL round bottom flask, and fully reacted to completion at 80 C (TLC tracking supervision) Measurement). After cooling to room temperature, suction filtration, the product was washed with a small amount of water, dissolved in N,N-dimethylformamide, filtered, and evaporated. The distilled water was precipitated as a solid, suction filtered, and recrystallized (DMSO) to give compound 8j in a yield of 80%. The structural formula of compound 8j is:The formula is: C18H15N6OSChinese name: 2,4-diamino-9-methyl-5-(1-methyl-1H-imidazol-2-ylthio)-5H-chromene[2,3-b]pyridine-3-carbonitrileThe English name is: 2,4-diamino-9-methyl-5-(1-methyl-1H-imidazol-2-ylthio)-5H-Chromeno[2,3-b]pyridine-3-carbonitrile

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-imidazole-2(3H)-thione, and friends who are interested can also refer to it.

Reference:
Patent; Jiangsu Normal University; Wu Hui; Yuan Rui; Ren Xuanxuan; Fang Yue; Chen Wen; Zhou Shengliang; Zhang Peng; Wan Yu; (15 pag.)CN108610348; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem