Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 59-48-3, name is Indolin-2-one, A new synthetic method of this compound is introduced below., category: indolines-derivatives
Oxindole (1.30 g, 0.010 mmol) was suspended in dry acetonitrile (22.0 mL) under N2 and cooled to -10 C. To this stirred mixture was added recrystallized NBS (2.00 g, 0.011 mol) portionwise. The resulting suspension was stirred at -10 to 10 C. for 3 h. The precipitated solid was collected by filtration, washed with H2O and dried to give the intermediate title compound as an off white solid 1.75 g (82%). Electrospray mass spectrum (M-1)=210, (M-1)=211
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Eli Lilly and Company; US7034045; (2006); B1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem