Category: 5857-47-6

Ikemoto, Tomomi published the artcileReactions with N-chlorosuccinimide of various 5-methylimidazo[1,2-a]pyridine derivatives with an electron-withdrawing group substituted at the 3-position, Formula: C8H7BrN2, the main research area is methylimidazopyridine preparation reaction chlorosuccinimide; pyridine methylimidazo preparation reaction chlorosuccinimide; imidazopyridine methyl preparation reaction chlorosuccinimide; chlorination mechanism methylimidazopyridine.

Chlorination reactions using N-chlorosuccinimide (NCS) was investigated for various 5-methylimidazo[1,2-a]pyridine derivatives, e.g. I (R = Cl, Br, NO2, CHO, CO2Et), with an electron-withdrawing group substituted at the 3-position. These reactions showed different results. Thus, reacting I (R = Cl) with NCS gave chloromethyl derivatives II (R1 = CH2Cl, CHCl2), whereas reacting I (R = Br) with NCS gave imidazopyridinium salts III (R2 = Br, Cl; X = Br, Cl). A proposed reaction mechanism for these transformations involved 3-halogenoimidazo[1,2-a]pyridium compounds as reaction intermediates.

Heterocycles published new progress about Chlorination. 5857-47-6 belongs to class imidazoles-derivatives, name is 3-Bromo-5-methylimidazo[1,2-a]pyridine, and the molecular formula is C8H7BrN2, Formula: C8H7BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hand, E. Smakula published the artcileReaction of 3-substituted imidazo[1,2-a]pyridines with bromine(1+) and the alleged 5-bromo-substituted product, Synthetic Route of 5857-47-6, the main research area is bromosuccinimide reaction imidazopyridine.

The reaction of 3-methylimidazo[1,2-a]pyridine with N-bromosuccinimide (I) gave products formed by apparent nucleophilic substitution at the 2-position. I in CHCl3 gave II and III, while I in CCl4 or Br2 in CHCl3 gave II exclusively. Mechanisms and differences in product formation are discussed; evidence is presented that the previously reported I product was in fact 3-bromo-5-methylimidazo[1,2-a]pyridine, rather than the alleged 5-bromo-3-Me derivative IV. IV was prepared by diazotization of 5-amino-3-methylimidazo[1,2-a]pyridine in the presence of HBr and by condensation of MeCHBrCHO (or its acetal) with 2-amino-6-bromopyridine.

Journal of Organic Chemistry published new progress about Reaction mechanism. 5857-47-6 belongs to class imidazoles-derivatives, name is 3-Bromo-5-methylimidazo[1,2-a]pyridine, and the molecular formula is C8H7BrN2, Synthetic Route of 5857-47-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem