Category: 5851-49-0

Application of 5851-49-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5851-49-0 as follows.

General procedure: The respective 1H-benz[d]imidazole(2.50 mmol) was dissolved in 10 ml of abs. DMF. Sodium hydride(60 % dispersion in mineral oil) (0.2 g, 5 mmol) was added withcooling. After the gas formation stopped, 4?-bromomethyl-[1,1?-biphenyl]-2-carbonitrildissolved in 2 ml of abs. DMF was added dropwise and the solution wasstirred for 1 h under cooling in an ice bath and further 2h at RT. Water wasadded and after the solution was acidified with HCl the product was extractedthree times with methylene chloride. The combined organic layers were driedover Na2SO4 and evaporated to dryness in vacuo. The crudeproduct was purified by column chromatography on silica gel with methylenechloride/methanol (95:5) and if necessary recrystallized from diethyl ether/methanol.

According to the analysis of related databases, 5851-49-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Obermoser, Victoria; Urban, Margarethe E.; Murgueitio, Manuela S.; Wolber, Gerhard; Kintscher, Ulrich; Gust, Ronald; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 138 – 152;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 5851-49-0, A common heterocyclic compound, 5851-49-0, name is 2-Heptyl-1H-benzo[d]imidazole, molecular formula is C14H20N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-Heptyl-benzimidazole (0.09 g, 0.42 mmol) was dissolved in acetonitrile (5 mL), potassium hydroxide (0.03 g, 0.53 mmol) was added and the mixture was refluxed for 30 min. 2-(Bromomethyl)naphthalene (0.11 g, 0.50 mmol) was added and the mixture was refluxed overnight.

The synthetic route of 5851-49-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Shelton, Kerri L.; DeBord, Michael A.; Wagers, Patrick O.; Southerland, Marie R.; Williams, Travis M.; Robishaw, Nikki K.; Shriver, Leah P.; Tessier, Claire A.; Panzner, Matthew J.; Youngs, Wiley J.; Bioorganic and Medicinal Chemistry; vol. 25; 1; (2017); p. 421 – 439;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem