Category: 583-42-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 583-42-6, name is 5-Fluoro-1H-benzo[d]imidazole-2(3H)-thione, A new synthetic method of this compound is introduced below., Quality Control of 5-Fluoro-1H-benzo[d]imidazole-2(3H)-thione

A suspension of 5-fluoro-lJ./-benzoimidazole-2-thiol (168 mg, 1 mmol), 5-bromo-pentanoic acid ethyl ester (188 mg, 0.9 mmol, 145 ILL.) and K2CO3 (276 mg, 2 mmol) inacetone (2 ml) is refluxed for 3 h. It is cooled down and filtered over a short plug ofsilica gel and rinsed with AcOEt. The solvent is removed in vacua. The crude ispurified by flash chromatography on silica-gel (AcOEt / heptane, 1 :2), yielding the titlecompound (190 mg) in 64% as a brown oil: fo = 1.87 min (LC-2), ESI-MS (pos.): m/z297.28 [M+H]+, ESI-MS (neg.): m/z 295.30 [M-H]+; .H-NMR (CDC13): 5 (ppm) 1.25(t, 3H, CH3), 1.79 (br. t, 4H), 2.36 (br. t, 2H, CH2CO), 3.28 (br. t, 2H, SCH2), 4.14 (q,2H, CHaO), 6.93 (dt, lHarom), 7.20 (dd, lHarom), 7.41 (dd, lHarom).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2006/21418; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 583-42-6,Some common heterocyclic compound, 583-42-6, name is 5-Fluoro-1H-benzo[d]imidazole-2(3H)-thione, molecular formula is C7H5FN2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE I 9 Preparation of 5-fluoro-2-[[(4-cyclopropylmethoxy-2-pyridinyl)methyl)thio]-1H-benzimidazole To 5-fluoro-2-mercapto-1H-benzimidazole (0.88 g, 0.0051 mol) in methanol (25 ml) NaOH (0.2 g, 0.0051 mol) dissolved in H2 O (1 ml) and 4-cyclopropylmethoxy-2-chloromethylpyridine hydrochloride (0.91 g, 0.0046 mol) dissolved in methanol (10 ml) were added in the given order. The mixture was heated to boiling and NaOH (0.2 g, 0.005 mol) dissolved in H2 O (1 ml) was added and the mixture was refluxed for 1 hour. After evaporation of methanol, CH2 Cl2 (75 ml) and H2 O (50 ml) were added and pH adjusted to 10. The mixture was vigorously stirred, the phases were separated, the organic phase was dried over Na2 SO4 and evaporated giving the desired product (1.25 g, 72%). NMR data for the product is given below.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Fluoro-1H-benzo[d]imidazole-2(3H)-thione, its application will become more common.

Reference:
Patent; Aktiebolaget Hassle; US5049674; (1991); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

These common heterocyclic compound, 583-42-6, name is 5-Fluoro-1H-benzo[d]imidazole-2(3H)-thione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H5FN2S

Step 2) Synthesis of 2-chloro-5-fluoro-1H-benzo [d] imidazole To a 50 mL of reaction flask were added 5-fluoro-1H-benzo [d] imidazole-2-thiol (1.00 g, 6.57 mmol) and phosphorus oxychloride (25 mL) . The mixture was refluxed for 13 h. After the reaction is complete, the mixture was concentrated to remove excess phosphorus oxychloride. The resulting mixture was quenched with saturated sodium bicarbonate solution (15 mL) , and extracted with ethyl acetate (10 mL ? 3) . The combined organic layers were dried over anhydrous sodium sulfate and concentrated in vacuo to give the title compound as a pale yellow solid (1.03 g, 92.0%) .MS (ESI, pos. ion) m/z: 171.05 [M+H] +.

The synthetic route of 5-Fluoro-1H-benzo[d]imidazole-2(3H)-thione has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; JIN, Chuanfei; ZHANG, Ji; (90 pag.)WO2017/88759; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem