Category: 583-39-1

Related Products of 583-39-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 583-39-1 as follows.

General procedure: A mixture of 0.001 mol of chloroethynylphosphonate1a-1c and 0.002 mol of benzimidazole-2-thione 2d in 15 mL of anhydrous acetonitrile was stirred at room temperature for 2-5 h. The precipitate was filtered off. The solvent was removed from the filtrate, the precipitate was combined and recrystallizedfrom ethanol. Yields and melting points of the obtained compounds are given in Table 1.

According to the analysis of related databases, 583-39-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Egorov; Piterskaya, Yu. L.; Kartsev; Polukeev; Krivchun; Dogadina; Russian Journal of General Chemistry; vol. 88; 9; (2018); p. 1824 – 1831; Zh. Obshch. Khim.; vol. 88; 9; (2018); p. 1478 – 1485,8;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

These common heterocyclic compound, 583-39-1, name is 2-Mercaptobenzimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C7H6N2S

General procedure: A mixture of 0.001 mol of chloroethynylphosphonate1a-1c and 0.002 mol of benzimidazole-2-thione 2d in 15 mL of anhydrous acetonitrile was stirred at room temperature for 2-5 h. The precipitate was filtered off. The solvent was removed from the filtrate, the precipitate was combined and recrystallizedfrom ethanol. Yields and melting points of the obtained compounds are given in Table 1.

The synthetic route of 2-Mercaptobenzimidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Egorov; Piterskaya, Yu. L.; Kartsev; Polukeev; Krivchun; Dogadina; Russian Journal of General Chemistry; vol. 88; 9; (2018); p. 1824 – 1831; Zh. Obshch. Khim.; vol. 88; 9; (2018); p. 1478 – 1485,8;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 583-39-1, name is 2-Mercaptobenzimidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 583-39-1, Formula: C7H6N2S

General method: Benzimidazole-2-thiol (7) (1 eq) and pertinent acid chloride or acid anhydride (1.1 eq) were dissolved in pyridine (4.4 eq) under a nitrogen atmosphere. The reaction mixture was stirred overnight at room temperature. After quenching with water (10-25 ml), ethyl acetate (30-45 ml) was added. The organic phase was extracted with 3M hydrochloric acid (3 ¡Á 25 ml), dried over magnesium sulfate and concentrated under reduced pressure. The crude product was purified as stated below.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Mercaptobenzimidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Braun, Stephan; Botzki, Alexander; Salmen, Sunnhild; Textor, Christian; Bernhardt, Guenther; Dove, Stefan; Buschauer, Armin; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 4419 – 4429;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 583-39-1, name is 2-Mercaptobenzimidazole, This compound has unique chemical properties. The synthetic route is as follows., name: 2-Mercaptobenzimidazole

General procedure: To a solution of benzazoles (0.05 mol) in ethanol, formaldehyde (aq. 37% solution, 0.5 ml) and 4-(4-nitrobenzyloxy)-aniline 2 were added with vigorous stirring and heated on a water bath for 5 min and left at room temp for overnight. The solid so obtained was washed with methanol and recrystallized from suitable solvent.

According to the analysis of related databases, 583-39-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Rastogi, Nisheeth; Kant, Padam; Indian Journal of Heterocyclic Chemistry; vol. 24; 1; (2014); p. 77 – 80;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 583-39-1, The chemical industry reduces the impact on the environment during synthesis 583-39-1, name is 2-Mercaptobenzimidazole, I believe this compound will play a more active role in future production and life.

Thione 2b (150 mg, 1.0 mmol) was added to a stirred solution of MeOK (77 mg, 1.1 mmol) in anhydrous MeOH (2 ml). The obtained solution was added to ketone 1d (311 mg, 1.0 mmol) in anhydrous MeOH (5 ml). The reaction mixture was stirred for 24 h, the precipitate that formed was filtered off, washed with cold 70% EtOH, and air-dried. Yield 245 mg (53%), light yellow crystals, mp 153-154C (Me2CO-H2O). IR spectrum, nu, cm-1: 3139, 3115, 3048, 1597, 1585, 1539,1517, 1496, 1477, 1440, 1406, 1007, 985, 965, 923, 905,880, 847, 827, 816, 794, 750, 717. 1H NMR spectrum, delta,ppm (J, Hz): 6.44 (1, d, J = 3.2, H Fur); 6.47 (1H, s,SCH); 6.90 (1, d, J = 3.2, H Fur); 7.13-7.19 (2, m,H Ar); 7.33 (1H, t, J = 7.2, H Ar); 7.38-7.43 (5, m,H Ar); 7.53-7.58 (3, m, H Ar); 7.61 (2, d, J = 7.8,H Ar); 12.76 (1H, s, NH). 13C NMR spectrum, delta, ppm:48.5; 107.9; 111.2 (2C); 118.3; 121.9; 122.6; 125.4 (2C);128.6 (3C); 129.2; 129.3 (2C); 129.4 (2C); 132.4; 135.7;138.5; 144.1; 148.0; 152.4; 153.5. Found, %: 62.38; 4.00. C24H17BrN2OS. Calculated, %: 62.48; 3.71.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Mercaptobenzimidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Golovanov, Alexander A.; Bekin, Vadim V.; Zlotskii, Simon S.; Kunavin, Yurii A.; Vologzhanina, Anna V.; Gusev, Dmitry M.; Bunev, Alexander S.; Chemistry of Heterocyclic Compounds; vol. 51; 10; (2015); p. 929 – 932; Khim. Geterotsikl. Soedin.; vol. 51; 10; (2015); p. 929 – 932,4;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A common heterocyclic compound, 583-39-1, name is 2-Mercaptobenzimidazole, molecular formula is C7H6N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 583-39-1.

Acetic anhydride (30 mL, 0.033 mol) was added to 1H-benzo[d]imidazole-2(3H)-thione 1 (5 g,0.033 mol) and the stirred mixture was heated to 110-115 C for 30 min. The solution was cooledthen water (150 mL) was added, and finally kept for 30 min at room temperature. Colorless crystalswere filtered off (6.21 g, 97% Yield); TLC, Rf = 0.773 (1:1, n-hexane:ethyl acetate). The product wasrecrystallized from benzene to give white crystals. m.p. 201-202 C, (lit. [21] m.p., 195 C); IR (KBr) nu 1716 (C=O), 1368 (CH3), 2996 (CH aliphatic), and 3146 (CH aromatic), 1591 cm-1 (C=C). 1H-NMR(CDCl3/D2O) delta: 1.92 (s, 3H, CH3), 7.19 (m, 2H, Ar-H), and 7.26 ppm (m, 2H, Ar-H). 13C-NMR(DMSO-d6) delta: 27.1 (CH3), 108.5 (CH), 114.3 (CH), 122.3 (CH), 124.3 (CH), 129.8 (C), 130.1 (C), 168.9(C=S), and 171.1 ppm (C=O).

The synthetic route of 2-Mercaptobenzimidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; El Ashry, El Sayed H.; Kilany, Yeldez El; Nahas, Nariman M.; Barakat, Assem; Al-Qurashi, Nadia; Ghabbour, Hazem A.; Fun, Hoong-Kun; Molecules; vol. 21; 1; (2016);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

583-39-1, A common compound: 583-39-1, name is 2-Mercaptobenzimidazole, belongs to imidazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

A mixture of 1H-benzo[d]imidazole-2(3H)-thione (III, 21 mg, 0.2 mmol) and [RuII(eta6-p-cymene)(PPh3)(CH3CN)Cl]PF6 (5, 144 mg, 0.2 mmol) in CH2Cl2 (20 mL) was stirred for 3 h at room temperature. The solvent was concentrated to a small amount (ca. 3 mL) and the product was precipitated by addition of pentane (ca. 20 mL). The orange yellow powder was filtered, washed with pentane (2 ¡Á 5 mL) and dried in vacuo. Yield: 146 mg (88%), m.p. 200 C (decomp.). Elemental analysis (%) calcd. for C35H35ClF6N2P2RuS*0.5CH2Cl2: C 48.97, H 4.17, N 3.22, S 3.68, found: C 49.02, H 4.38, N 3.29, S 3.74. 1H-NMR (CDCl3): delta = 11.46 (s, 2H, NH),7.58-7.62 (m, 6 H, PPh3), 7.34-7.37 (m, 10H, PPh3/Ar-thione), 7.24-7.27 (m, 3H, PPh3), 5.47 (d, J = 6 Hz, 1 H, H-Ar), 5.31 (d, J = 6 Hz, 1 H, H-Ar), 5.21 (d, J = 6 Hz, 1 H, H-Ar), 5.06 (d, J = 6 Hz, 1 H, H-Ar), 2.81-2.89 (m, 1 H,CH(CH3)2), 1.90 (s, 3 H, CH3), 1.18 (d, J = 7 Hz, 3H, CH(CH3)2), 1.16 (d, J = 7 Hz, 3H, CH(CH3)2) ppm. 13C{1H}-NMR (CDCl3): delta = 163.8 (C=S), 134.1 (C-PPh3), 132.0 (C-PPh3), 131.6 (C-Arthione), 131.1 (C-Arthione), 130.8 (C-PPh3), 128.4 (C-PPh3), 124.6 (C-Arthione), 116.5 (C-Ar), 111.7 (C-Arthione), 101.1 (C-Ar), 92.0 (d, J = 2 Hz, C-Ar), 91.3 (d, J = 4 Hz, C-Ar), 90.0 (d, J = 2 Hz, C-Ar), 89.0 (d,J = 4 Hz, C-Ar), 30.5 (CH(CH3)2), 22.5(CH(CH3)2), 21.4 (CH(CH3)2), 17.6 (CH3) ppm. 31P{1H}-NMR(CDCl3): delta = 29.5 (s, PPh3), -144.2 (sept, PF6) ppm.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Mercaptobenzimidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Hanif, Muhammad; Nawaz, Muhammad Azhar Hayat; Babak, Maria V.; Iqbal, Jamshed; Roller, Alexander; Keppler, Bernhard K.; Hartinger, Christian G.; Molecules; vol. 19; 6; (2014); p. 8080 – 8092;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 583-39-1, name is 2-Mercaptobenzimidazole, A new synthetic method of this compound is introduced below., 583-39-1

General procedure: To an orange suspension of [Pd2(kappa2:C, N-mazb)2(mu-Cl)2] (0.025g, 0.040mmol) in dichloromethane (5mL), N-methylimidazolidine-2-thione (0.012g, 0.080mmol) was added in presence of Et3N base (0.5mL). The color of the reaction mixture became red brown and was stirred for 5-6h. The solution was filtered and methanol (5mL) was added and was left to evaporate slowly. The red brown crystals of compound 7 were obtained after a period of 4-5d.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Sandhu, Amanpreet K.; Lobana, Tarlok S.; Sran, Balkaran S.; Hundal, Geeta; Jasinski, Jerry P.; Journal of Organometallic Chemistry; vol. 861; (2018); p. 112 – 124;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

583-39-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions

Benzimid-azole-2-thione 1 (1.50 g, 10 mmol) and morpholine (0.87 ml, 0.87 g, 10 mmol) were dissolved in 2-PrOH (30 ml); 37% aqueous formaldehyde (0.90 ml, 12 mmol) was added, and the mixture was refluxed for 3 h (precipitate formed almost immediately). Th

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Bespalov; Gorchakova; Ivanov; Kuznetsov; Kuznetsova; Pankova; Prokopenko; Avdontceva; Chemistry of Heterocyclic Compounds; vol. 50; 11; (2015); p. 1547 – 1558;,
Author Jessica.FPosted on November 18, 2020Categories 583-39-1, imidazoles-derivativesTags M.W=100-200

583-39-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 583-39-1, name is 2-Mercaptobenzimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To the solution of PdCl2(PPh3)2 (0.050 g, 0.07 mmol) dissolvedin 10 mL of CH3CN, bzimSH (0.021 g, 0.14 mmol) was added followedby Et3N base (0.5 mL). The solution became turbid and yellowishorange in color. Then the refluxing was done for 6 h. Thecolor of the reaction mixture became orange and was filtered.The filtrate was evaporated using rotary evaporator until a solidwas obtained. It was treated with acetone which dissolved thecomplex leaving behind Et3NH+Cl, white solid. The acetone solutionwas filtered to remove Et3NH+Cl. To it was added 4 mLdichloromethane-methanol (1:1, v/v) mixture and left to evaporateat room temperature. The orange colored crystals of compound2 were formed in a period of 10-15 days (67%, m.p 218-220 C). Anal. Calc. for C75H61ClN6P3Pd2S32H2O (1519.67): C,59.22; H, 4.01; N, 5.53. Found: C, 59.80; H, 4.36; N, 5.52%. IRbands(KBr, cm1): nu(O-H), 3393m (b); m(C-H), 3051m, 2963w; nu(C-C) + nu(C-N) + delta(C-H), 1618s, 1479m, 1433s, 1391s, 1263m,1226w;, 1182 w; nu(P-CPh), 1096s; nu(C-S) 1022s; 802m, 741s,691s, nu(Pd-N), 523s; 422w. ESI Mass could not be recorded dueto poor solubility.

The synthetic route of 2-Mercaptobenzimidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lobana, Tarlok S.; Sandhu, Amanpreet K.; Mahajan, Rakesh K.; Hundal, Geeta; Gupta, Sushil K.; Butcher, Ray J.; Castineiras, Alfonso; Polyhedron; vol. 127; (2017); p. 25 – 35;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem