Category: 583-39-1

Adding a certain compound to certain chemical reactions, such as: 583-39-1, name is 2-Mercaptobenzimidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 583-39-1, Safety of 2-Mercaptobenzimidazole

A mixture of 0.1 g of benzimidazole-2-thione, 0.374 g of benzyl acetate 1, and 5 mL of methanol was kept at room temperature for 20 days. The precipitate was filtered off, washed with methanol, and dried in air. Yield 0.21 g (54%), mp 243-245C (mp 244-245C [13]). 1H NMR spectrum (CDCl3), delta, ppm: 1.42 s (36H, CMe3), 5.18 s (2H,OH ), 5.52 s (4H, CH2N), 7.12-7.25 m (4H, ArH), 7.40 s (4H, ArH).

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Reference:
Article; Gataullina; Mogilevtseva; Nugumanova; Bukharov; Tagasheva; Deberdeev, R. Ya.; Russian Journal of General Chemistry; vol. 87; 9; (2017); p. 1919 – 1923; Zh. Obshch. Khim.; vol. 87; 9; (2017); p. -1435 – -1439,5;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 583-39-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 583-39-1 as follows.

Sodium hydroxide (1.60 g, 40 mmol) was dissolved in 2-PrOH (70 ml), benzimidazole-2-thione 1 (6.00 g, 40 mmol) was added followed by portionwise addition of chloroacetamide (3.75 g, 40 mmol). The reaction mixture was refluxed for 3 h, cooled, the precipitate was filtered off, washed with water, and dried. Yield 6.75 g (81%), colorless crystals

According to the analysis of related databases, 583-39-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Bespalov; Gorchakova; Ivanov; Kuznetsov; Kuznetsova; Pankova; Prokopenko; Avdontceva; Chemistry of Heterocyclic Compounds; vol. 50; 11; (2015); p. 1547 – 1558;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 583-39-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 583-39-1, name is 2-Mercaptobenzimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General method: Benzimidazole-2-thiol (7) (1 eq) and pertinent acid chloride or acid anhydride (1.1 eq) were dissolved in pyridine (4.4 eq) under a nitrogen atmosphere. The reaction mixture was stirred overnight at room temperature. After quenching with water (10-25 ml), ethyl acetate (30-45 ml) was added. The organic phase was extracted with 3M hydrochloric acid (3 × 25 ml), dried over magnesium sulfate and concentrated under reduced pressure. The crude product was purified as stated below.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Mercaptobenzimidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Braun, Stephan; Botzki, Alexander; Salmen, Sunnhild; Textor, Christian; Bernhardt, Guenther; Dove, Stefan; Buschauer, Armin; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 4419 – 4429;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 583-39-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 583-39-1, name is 2-Mercaptobenzimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A solution of 2-mercaptobenzimidazole (0.15 g, 1.0 mmol) in methanol(10 mL) was added to a solution of BiI3 (0,294 g, 0.5 mmol) inacetonitrile (10 mL). The resulting solution was stirred for 3 h at 50 C.The solution obtained was filtered and slowly evaporated until the redcrystals were isolated. Yield: % 79.5; mp, 234-238 C; mw, 1780, 19 g/mol. Elemental Anal. Calc. for C28H24Bi2I6N8S4: C, 18.89; H, 1.36; N,6.29; S, 7.20. Found: C, 18.92; H, 1.38; N, 6.32; S, 7.29. UV-Vis(DMSO): lambdamax (logepsilon): 312.50 (5.28), 257.00 (4.90). IR (cm-1): 3198 m,2361m, 1620m, 1491s, 1450s, 1396m, 1344m, 1252w, 1165m, 1149w,1009m, 974m, 926w, 810w, 742s, 671m, 596s, 567w, 410m. 13C NMR[400 MHz, DMSO-d6, delta(ppm)]: 168.71 (C]S), 133.17 (C4, C5), 123.34(C7, C8), 110.49 (C6, C9). Soluble in methanol, acetonitrile, acetone,tetrahydrofuran, dimethylsulfoxide. LambdaM=45.2 Omega-1·cm2·mol-1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Mercaptobenzimidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ozturk; Banti; Hadjikakou; Panagiotou; Tasiopoulos; Inorganica Chimica Acta; vol. 497; (2019);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 583-39-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 583-39-1, name is 2-Mercaptobenzimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Benzyl chloride or 1-iodopropane, 89.25 mmol, and potassium carbonate, 170.0 mmol, were added to a solution of 85.0 mmol of 1,3-dihydro-2H-benzimidazole-2-thione in 140 mL of acetone. The mixture was refluxed for 3 h with stirring and poured into water with stirring to dissolve inorganic com-ponents. The precipitate was filtered off and washed with water and methanol. Compound 1b was dried and recrystallized from 20 mL of methanol. Compound 1a required no additional purification. Compound 1a. Yield 93%, colorless crystals, mp 180-181C. 1 H NMR spectrum, delta, ppm: 4.56 s (2H, CH 2 ), 7.07 t (2H, H arom , J = 4.0 Hz), 7.21 t (1H, H arom , J = 6.8 Hz), 7.28 t (2H, H arom , J = 7.2 Hz), 7.35-7.45 m (4H, H arom ), 12.04 br.s (1H, NH). Compound 1b. Yield 55%, colorless crystals, mp 151-152C. 1 H NMR spectrum, delta, ppm: 1.07 t (3H, CH 3 , J = 7.2 Hz), 1.80 sext (2H, CH 2 , J = 6.8 Hz), 3.25 t (2H, CH 2 , J = 7.2 Hz), 7.05 s (2H, H arom ), 7.37 s (1H, H arom ), 12.27 s (1H, NH).

The synthetic route of 2-Mercaptobenzimidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kharaneko; Russian Journal of Organic Chemistry; vol. 54; 9; (2018); p. 1363 – 1368; Zh. Org. Khim.; vol. 54; 9; (2018); p. 1350 – 1354,5;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 583-39-1, name is 2-Mercaptobenzimidazole, A new synthetic method of this compound is introduced below., Quality Control of 2-Mercaptobenzimidazole

a. A mixture of 0.46 g (0.0016 mol) of benzyl acetate 6, 0.25 g (0.0016 mol) of 1,3-dihydrobenzimidazole-2-thione, 3 mL of acetone, and 3 mL of formic acid was heated at 40C for 6 h. The reaction mixture was cooled down to ambient temperature and poured into aqueous NaCl. The precipitate that formed was filtered off, washed with water, and dried in air. Yield 0.56 g (92%), mp 168-170C (benzene). 1H NMR spectrum (CDCl3), delta,ppm: 1.34 s (18H, CMe3), 4.73 s (2H, CH2N), 5.23 s(1H, OH), 7.17 s (2H, ArH), 7.23-7.30 m (2H, H5,6),7.71-7.78 m (2H, H4,7). Found, %: C 71.45; H 7.83; N 7.27. C22H28N2OS. Calculated, %: C 71.70; H 7.66; N 7.60. b. A solution of benzyl acetate 6 and 1,3-dihydrobenzimidazole-2-thione in a 1 : 1 mixture of acetone and formic acid at ambient temperature for 2 days to obtain 98% of compound 12.

The synthetic route of 583-39-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Tagasheva; Gataullina; Zaripova; Bukharov; Nugumanova; Deberdeev; Voronina, Yu. K.; Russian Journal of General Chemistry; vol. 87; 1; (2017); p. 22 – 28; Zh. Obshch. Khim.; vol. 87; 1; (2017); p. 26 – 32,7;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 583-39-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 583-39-1, name is 2-Mercaptobenzimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Benzyl chloride or 1-iodopropane, 89.25 mmol, and potassium carbonate, 170.0 mmol, were added to a solution of 85.0 mmol of 1,3-dihydro-2H-benzimidazole-2-thione in 140 mL of acetone. The mixture was refluxed for 3 h with stirring and poured into water with stirring to dissolve inorganic com-ponents. The precipitate was filtered off and washed with water and methanol. Compound 1b was dried and recrystallized from 20 mL of methanol. Compound 1a required no additional purification. Compound 1a. Yield 93%, colorless crystals, mp 180-181C. 1 H NMR spectrum, delta, ppm: 4.56 s (2H, CH 2 ), 7.07 t (2H, H arom , J = 4.0 Hz), 7.21 t (1H, H arom , J = 6.8 Hz), 7.28 t (2H, H arom , J = 7.2 Hz), 7.35-7.45 m (4H, H arom ), 12.04 br.s (1H, NH). Compound 1b. Yield 55%, colorless crystals, mp 151-152C. 1 H NMR spectrum, delta, ppm: 1.07 t (3H, CH 3 , J = 7.2 Hz), 1.80 sext (2H, CH 2 , J = 6.8 Hz), 3.25 t (2H, CH 2 , J = 7.2 Hz), 7.05 s (2H, H arom ), 7.37 s (1H, H arom ), 12.27 s (1H, NH).

The synthetic route of 2-Mercaptobenzimidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kharaneko; Russian Journal of Organic Chemistry; vol. 54; 9; (2018); p. 1363 – 1368; Zh. Org. Khim.; vol. 54; 9; (2018); p. 1350 – 1354,5;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 583-39-1, name is 2-Mercaptobenzimidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 583-39-1, Quality Control of 2-Mercaptobenzimidazole

A mixture of 1H-benzo[d]imidazole-2(3H)-thione 1 (0.026 mole, 5 gm) in 60 mL ethanol and inpresence of triethylamine (0.01 mol, 1.39 mL) was refluxed for 1 h, then 1,3-dibromopropane (0.013 mol,2.6 g) was added. The reaction mixture was further heated under reflux for 5 h. Then, ethanol wasremoved under vacuum, and water (20 mL) was added to the product, and kept for 24 h at roomtemperature to give white crystals. The product (4.68 g, 83% yield), was recrystallized from ethanol,TLC, Rf = 0.382 (1:1, n-hexane:ethyl acetate), m.p. 201-202 C. 1H-NMR (DMSO-d6) : 2.29 (m, 2H,CH2), 3.26 (t, 2H, CH2), 4.17 (t, 2H, CH2), 7.11 (m, 2H, Ar-H), and 7.39 ppm (m, 2H, Ar-H). 13C-NMR(DMSO-d6) : 21.9 (CH2), 24.3 (CH2), 41.7 (CH2), 107.9 (CH), 116.1 (CH), 120.02 (CH), 120.94 (CH),134.69 (C), 134.81 (C), 141.4; 145.75 ppm (C=N). Calc. for C10H10N2S (190.26): C, 63.13; H, 5.30;N, 14.72%. Found: C, 63.42; H, 5.11; N, 14.41%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; El Ashry, El Sayed H.; Kilany, Yeldez El; Nahas, Nariman M.; Barakat, Assem; Al-Qurashi, Nadia; Ghabbour, Hazem A.; Fun, Hoong-Kun; Molecules; vol. 21; 1; (2016);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 583-39-1, These common heterocyclic compound, 583-39-1, name is 2-Mercaptobenzimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General method: Benzimidazole-2-thiol (7) (1 eq) and pertinent acid chloride or acid anhydride (1.1 eq) were dissolved in pyridine (4.4 eq) under a nitrogen atmosphere. The reaction mixture was stirred overnight at room temperature. After quenching with water (10-25 ml), ethyl acetate (30-45 ml) was added. The organic phase was extracted with 3M hydrochloric acid (3 × 25 ml), dried over magnesium sulfate and concentrated under reduced pressure. The crude product was purified as stated below.

The synthetic route of 583-39-1 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 583-39-1, name is 2-Mercaptobenzimidazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 583-39-1

A mixture of benzimidazole-2-thione (7) (1.5 g, 10 mmol), triethylamine (2.88 g, 28.5 mmol), a catalytic amount (100 mg) of DMAP and anhydrous dichloromethane was stirred at room temperature for 10 min. A solution of acetyl chloride (2.83 g) and anhydrous dichloromethane was added dropwise and stirring was continued for 16 h. After diluting with water (100 ml) and dichloromethane (50 ml), the organic layer was separated, washed three times with an aqueous solution of potassium hydrogen sulfate (1 M, 50 ml) and water (50 ml) and dried over sodium sulfate. The solvent was removed under reduced pressure, and the product was purified by column chromatography on silica gel eluting with a 1:8 (v/v) mixture containing ethyl acetate and petroleum ether at 60-80 C to give a white solid. The product decomposes at ambient temperature and moisture to 1-acetylbenzimidazole-2-thione. Yield 1.3 g (5.55 mmol), 56%, white solid. Mp: 100-102 C (Mp: 102-103 C refPreviewPlaceHolder[40]). 1H NMR (CDCl3) delta 3.05 (s, 6H, OCH3), 7.31 (dd, 2H, 4J = 3.4 Hz, 3J = 6.3 Hz, H-5 and H-6), 7.97 (dd, 2H, 4J = 3.4 Hz, 3J = 6.3 Hz, H-4 and H-7). MS (EI) m/z 234 (M+). Anal. (C11H10N2O2S) C, H, N, S.

According to the analysis of related databases, 583-39-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Braun, Stephan; Botzki, Alexander; Salmen, Sunnhild; Textor, Christian; Bernhardt, Guenther; Dove, Stefan; Buschauer, Armin; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 4419 – 4429;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem