Category: 58235-81-7

Related Products of 58235-81-7. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Methyl 5-chlorofuran-2-carboxylate, is researched, Molecular C6H5ClO3, CAS is 58235-81-7, about Synthesis of tetrakis(2-furyl)methane. Author is Kurata, Hiroyuki; Oki, Yoshiaki; Matsumoto, Kouzou; Kawase, Takeshi; Oda, Masaji.

The parent tetrakis(2-furyl)methane (I) is synthesized using aromatic nucleophilic substitution on 2-chlorofurans as a key reaction. X-ray anal. reveals the shortest bond length between the central methane carbon and furyl ipso-carbons among known tetraarylmethanes. Successful tetrabromination and tetralithiation promise its high synthetic utility.

This compound(Methyl 5-chlorofuran-2-carboxylate)Related Products of 58235-81-7 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Name: Methyl 5-chlorofuran-2-carboxylate. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Methyl 5-chlorofuran-2-carboxylate, is researched, Molecular C6H5ClO3, CAS is 58235-81-7, about QSAR in a series of muscarinic agents. Note II. Pyridine and furan derivatives. Author is Pratesi, P.; Villa, L.; Ferri, V.; De Micheli, C.; Grana, E.; Santagostino Barbone, M. G.; Grieco, C.; Silipo, C.; Vittoria, A..

Substituted furfuryl- and picolyltrimethylammonium salts, some of which were synthesized, were evaluated for ligand-muscarinic receptor interaction on isolated rat jejunum. The affinity of the ligand, expressed as pD2 values, was dependent on hydrophobic and steric parameters of the ring substituent. QSARs between muscarinic receptor and ligand are discussed.

Different reactions of this compound(Methyl 5-chlorofuran-2-carboxylate)Name: Methyl 5-chlorofuran-2-carboxylate require different conditions, so the reaction conditions are very important.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Martinez, Roberto; Espitia-Pinzon, Clara I.; Silva Miranda, Mayra; Chavez-Santos, Rosa Maria; Pretelin-Castillo, Gustavo; Ramos-Orea, Aldahir; Hernandez-Baez, Angela M.; Cotlame-Perez, Sandra; Pedraza-Rodriguez, Rogelio researched the compound: Methyl 5-chlorofuran-2-carboxylate( cas:58235-81-7 ).Reference of Methyl 5-chlorofuran-2-carboxylate.They published the article 《Synthesis and antituberculosis activity of new acylthiosemicarbazides designed by structural modification》 about this compound( cas:58235-81-7 ) in Drug Development Research. Keywords: benzamidocarbamothioyl pyridinecarboxamide preparation antituberculosis activity SAR; acylthiosemicarbazides; antituberculosis agents; design; isosteric modification; synthesis. We’ll tell you more about this compound (cas:58235-81-7).

Acylthiosemicarbazides I [R = 5-nitro-1H-pyrrol-2-yl, 4-chlorophenyl, 5-nitrofuran-2-yl, etc.; R1 = 5-chloropyrrol-2-oyl, 4-chlorophenyl, 3,4-dichlorophenyl, etc.] were designed by structural modification of lead N-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)5-nitrofuran-2-carboxamide. The syntheses of I involve a five-step procedure starting from carboxylic acids. Compounds I were tested against three Mycobacterium tuberculosis strains to measure their inhibitory antituberculosis activities. These activities were explained according to the presence or absence of the chlorine substituent in the aromatic ring of the amide joined to the thiosemicarbazide core. Thiosemicarbazide derivative I [R = R1 = phenyl] is a candidate for the development of novel antitubercular agents. Ongoing studies are focused on exploring the mechanism by which these compounds inhibit M. tuberculosis cell growth.

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Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Ultraviolet spectra of 2-substituted furans and 5-substituted methyl furoates》. Authors are Manly, Donald G.; Amstutz, E. D..The article about the compound:Methyl 5-chlorofuran-2-carboxylatecas:58235-81-7,SMILESS:O=C(C1=CC=C(Cl)O1)OC).Reference of Methyl 5-chlorofuran-2-carboxylate. Through the article, more information about this compound (cas:58235-81-7) is conveyed.

Ultraviolet spectral data for simple furan compounds are reported. 2-Substituted furans were prepared by the methods of Manly and Amstutz (C.A. 51, 3549f). Passing Cl through rapidly stirred Me 2-furoate 3 hrs. at 150° gave 42% 5-Cl derivative, m. 40-1°, and 5-methoxy-2-furoates were prepared as previously reported (loc. cit.). 5-Phenylthio-2-furoic acid (loc. cit.) with CH2N2 gave 98% Me ester (I), b0.5 146-8° m. 39-40°. I with excess 30% H2O2 in AcOH gave a quant. yield of Ph 5-carbomethoxy-2-furyl sulfone, needles, m. 102-3°. Me 5-nitro-2-furoate, m. 79-80°, was prepared by the method of Freure and Johnson (C.A. 25, 1825). Carbonation of 4-PhOC6H4MgBr gave the acid, m. 158-9°; Me ester, m. 56-7° (95% EtOH), λmaximum 258.0 mμ (log ε 4.26). Addition of 4-HO2CC6H4N2Cl to PhSH in cold dilute NaOH gave a poor yield of 4-PhSC6H4CO2H, m. 170-4° (95% EtOH); Me ester (II), m. 69-70°, λmaximum 293.2 mμ (log ε 4.23). II with H2O2 yielded 4-PhSO2C6H4CO2Me, m. 145-6° (95% EtOH), λ 242.5 mμ (log ε 4.29). Other compounds reported (m.p. or b.p., λmaximum (mμ), and log ε given): BzOMe, b15 85°, 220.8, 4.08; 4-BrC6H4CO2Me, m. 77-8°, 245.0, 4.26; 4-MeOC6H4CO2Me, m. 47-8°, 256.5, 4.43; 4-O2NC6H4CO2Me, m. 95-6°, 259.0, 4.12; 1,4-C6H4(CO2Me)2, m. 139-40°, 242.5 4.47; Ph2SO2, m. 128-30°, 236.3 4.17; Ph2S, b15 151-3°, 231.8, 3.80; Ph2O, b12 129.5°, 226.7, 4.01. The following ultraviolet spectral data are reported for the 2-substituted furans [2-substituent, λmaximum (mμ), log ε, Δ λ(λmaximum – λ where λ = 208), ΔλPh (λmaximum – λ where λ = 203.5 given]: H, 208 (by extrapolation), 3.9, 0, 0; Br, 215.5, 3.99, 7.5, 6.5; MeO, 221.0, 3.82, 13.0, 13.5; PhO, 222.0, 4.06, 14.0, 23.2; PhS, 241.5, 4.21, 33.5, 28.3; PhSO2, 249.5, 4.13, 41.5, 32.8; MeO2C, 252.1, 4.13, 44.1, 26.3. The following ultraviolet spectral data are reported for the Me 5-substituted-2-furoates (5-substituent given): H, 252.1, 4.13, 44.1, 26.3; Cl, 260.5, 4.23, 52.5, 37.5; PhSO2, 261.7, 4.33, 53.7, 39.0; Br, 264.1, 4.23, 56.1, 41.5; MeO2C, 264.6, 4.19, 56.6, 38.5; PhO, 275.0, 4.25, 67.0, 54.5; MeO, 279.0, 4.10, 71.5, 53.0; PhS, 291.8, 4.33, 83.8, 89.7; O2N, 295.4, 4.08, 87.4, 55.0.

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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

COA of Formula: C6H5ClO3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Methyl 5-chlorofuran-2-carboxylate, is researched, Molecular C6H5ClO3, CAS is 58235-81-7, about Infrared examination of rotational isomerism in alkyl furan-2-carboxylates: determination of thermodynamic parameters from infrared data. Author is Chadwick, Derek J.; Chambers, John; Macrae, Robert; Meakins, G. Denis; Snowden, Roger L..

Addnl. data considered in abstracting and indexing are available from a source cited in the original document. Solutions of 66 alkyl furan-2-carboxylates in CCl4 and MeCN were examined at high dispersion in the ir C:O region. In CCl4 one ester shows 4 bands, 8 show single bands, and 57 show well-separated doublets. With 1 exception, the doublets are due to rotational isomerism between syn-S-trans and anti-s-trans forms. The higher waveno. component of a doublet arises from the form with the higher dipole moment and higher enthalpy, probably the syn-s-trans rotamer. The failure of attempts to obtain reliable free energy and entropy differences reveals the shortcomings of standard approaches to the determination of energy differences between rotational isomers from ir data.

From this literature《Infrared examination of rotational isomerism in alkyl furan-2-carboxylates: determination of thermodynamic parameters from infrared data》,we know some information about this compound(58235-81-7)COA of Formula: C6H5ClO3, but this is not all information, there are many literatures related to this compound(58235-81-7).

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Khimiya Geterotsiklicheskikh Soedinenii called Reactions of aromatic and heteroaromatic compounds bearing electron-acceptor substituents. XX. Possible ways of forming chlorosubstituted compounds during bromination of complexes of some furan carbonyl compounds with aluminum halides, Author is Belen’kii, L. I.; Gromova, G. P.; Gol’dfarb, Ya. L., which mentions a compound: 58235-81-7, SMILESS is O=C(C1=CC=C(Cl)O1)OC, Molecular C6H5ClO3, Reference of Methyl 5-chlorofuran-2-carboxylate.

The conflict between the authors’ results and those of Chadwick et al. (1973) was explained by the different methods of product anal. NMR chem. shifts, in conjunction with gas chromatog., are most reliable for anal. of the halogenated furan products.

There is still a lot of research devoted to this compound(SMILES：O=C(C1=CC=C(Cl)O1)OC)Reference of Methyl 5-chlorofuran-2-carboxylate, and with the development of science, more effects of this compound(58235-81-7) can be discovered.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Studies of furan derivatives. I. Synthesis of chlorofuran derivatives, published in 1958, which mentions a compound: 58235-81-7, Name is Methyl 5-chlorofuran-2-carboxylate, Molecular C6H5ClO3, HPLC of Formula: 58235-81-7.

Tetrachloro-2-furoic acid (I) dissolved in methanol, dropped into methanolic NaOH solution, previously chilled below 0°, with stirring, the mixture kept 24 hrs., and methanol removed under reduced pressure, gave 3,4-dichloro-2-furoic acid (II), m. 167-8° (dilute EtOH). II (8 g.) heated in 50 cc. water at 100°, 20 g. 1% Na-Hg added gradually, and the mixture kept at 100° for 1 hr. with stirring, cooled, and acidified deposited 3.8 g. 3-chloro-2-furoic acid (III), m. 148-9° (water). III yielded a chloride (IV) with SOCl2. IV added 1 mole Cl; the mixture was distilled at room pressure, the fraction b. 180-20° gradually added to a cold ethanolic solution of NaOH with stirring, the deposit filtered off, and dissolved in water, and the solution acidified with HCl to give 5-chloro-2-furoic acid (V), yield 4%, m. 176-7° (dilute MeOH). A similar run with Me 5-chloro-2-furoate (VI), which was prepared from 30 g. V, 60 cc. ethanol, and 15 g. concentrated H2SO4, gave 3,5-dichloro-2-furancarboxylic acid (VII) in 22% yield, m. 155-6° (dilute methanol). The acid chloride of II (8 g.), heated with 0.8 g. Pd-BaSO4 (5%) and 75 cc. dry xylene in 140-5° oil bath while passing H with stirring, gave 3,4-dichlorofurfural in 83% yield, m. 52-3°. A similar run with the chlorides of III, VI, and VII gave 3-chlorofurfural (VIII), 60%, m. 28°, 5-chlorofurfural, 7%, m. 31-3%, and 3,5-chlorofurfural, 59%, m. 11-13°, b4 59-61°, resp.

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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem