Category: 5805-53-8

Cooper, G. published the artcile1-styrylimidazoles, Related Products of imidazoles-derivatives, the main research area is styrylimidazole; imidazole styryl; benzimidazole styryl; dehydration hydroxyphenylethylimidazole.

Addnl. data considered in abstracting and indexing are available from a source cited in the original document. Styrene oxide reacted with imidazole, its 2-methyl, 2-phenyl, and 4,5-diphenyl derivatives and benzimidazole in DMF in the presence of catalytic quantities of K at room temperature to give 45-98% of the corresponding 1-(2-hydroxy-2-phenylethyl)imidazole, which on heating with SOCl2 and KOH were dehydrated to give 51-90% trans-1-styrylimidazoles.

Journal of the Chemical Society, Perkin Transactions 6: Organic and Bio-Organic Chemistry published new progress about styrylimidazole; imidazole styryl; benzimidazole styryl; dehydration hydroxyphenylethylimidazole. 5805-53-8 belongs to class imidazoles-derivatives, name is Methyl 1H-benzo[d]imidazole-2-carboxylate, and the molecular formula is C9H8N2O2, Related Products of imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Zhao, Yaohong published the artcileApplication of molecular probe to investigate surface structure of metal passivator on copper, Recommanded Product: Methyl 1H-benzo[d]imidazole-2-carboxylate, the main research area is copper sulfide surface structure metal passivator investigative.

Copper sulfide (Cu2S) contaminant is semi-conductive. Its formation and migration to insulating paper and oil caused insulation breakdown. Addition of benzotriazole derivatives as metal passivator slows down the corrosion process, as the metal passivator produces a protective layer on the copper surface, which prevents the reaction between corrosive sulfur and copper. But the surface structure of this impermeable film is still unknown. Herein we reported our investigation on the orientation of metal-passivator complex on copper surface by means of mol. probe. Ageing exptl. study with different steric and electronic groups in benzotriazole skeleton indicated that the second position of the mol. was sensitive to steric effect, suggesting end-on orientation preferable. Subsequently, SEM-EDX revealed the relative amount of copper sulfide on copper surface. Moreover, FTIR represented the characteristic wavenumber of C=O, C=N moiety and benzene skeleton of passivator-copper complex. XPS anal. delivered the organic elemental composition of the protective layer.

IEEE Transactions on Dielectrics and Electrical Insulation published new progress about Corrosion. 5805-53-8 belongs to class imidazoles-derivatives, name is Methyl 1H-benzo[d]imidazole-2-carboxylate, and the molecular formula is C9H8N2O2, Recommanded Product: Methyl 1H-benzo[d]imidazole-2-carboxylate.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Melo, M. J. published the artcilePhotochemistry of 2-(2-furyl)benzimidazole (Fuberidazole), COA of Formula: C9H8N2O2, the main research area is photolysis furylbenzimidazole; benzimidazole furyl photolysis; Fuberidazole photolysis.

The photodegradation of 2-(2-furyl)benzimidazole (Fuberidazole) has been reinvestigated employing advanced HPLC-UV/VIS technique and fluorescence emission and excitation spectroscopy in methanol at natural pH, in acidic medium and in aqueous solutions at pH 7 and 3; four main products, benzimidazole-2-carboxylic acid, its Me ester, 1-methoxybenzimidazole, and Me 4-oxo-2-benzimidazolecrotonate (cis and trans isomers), besides benzimidazole and 2,2′-bibenzimidazole and other side products, have been isolated and characterized. The kinetics of the photodegradation process were followed independently by HPLC-UV and fluorescence emission and showed significant similarity; this allowed monitoring of a photodegradation at very low concentrations (5 × 10-5-5 × 10-6 M). The quantum yield of disappearance of Fuberidazole has been determined

Zeitschrift fuer Naturforschung, B: Chemical Sciences published new progress about Photolysis. 5805-53-8 belongs to class imidazoles-derivatives, name is Methyl 1H-benzo[d]imidazole-2-carboxylate, and the molecular formula is C9H8N2O2, COA of Formula: C9H8N2O2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ennis, B. C. published the artcile2-Trihalomethylbenzazoles. III. Reactions of 2-(trichloromethyl)benzimidazole with nucleophiles, Product Details of C9H8N2O2, the main research area is BENZAZOLES; BENZIMIDAZOLES; IMIDAZOLES BENZ.

cf. preceding abstracts Nucleophilic displacements of Cl from 2-(trichloromethyl)benzimidazole (I) by water, alcs., phenols, and their S analogs are described. The special reactivity of the trichloromethyl group in this compound is compared with that of the trichloromethyl group in non-activated positions. The Friedel-Crafts reaction of 2-(trichloromethyl)benzimidazole with benzene is reported.

Journal of the Chemical Society [Section] C: Organic published new progress about Nucleophiles. 5805-53-8 belongs to class imidazoles-derivatives, name is Methyl 1H-benzo[d]imidazole-2-carboxylate, and the molecular formula is C9H8N2O2, Product Details of C9H8N2O2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kiselyov, Alexander S. published the artcileNovel inhibitors of VEGF receptors-1 and -2 based on azole-5-carboxamide templates, Quality Control of 5805-53-8, the main research area is inhibitor VEGF receptor azole carboxamide preparation SAR.

We have developed a series of novel potent 1-(2-(pyridin-4-yl)ethyl)-1H-azole-5-carboxamides active against kinases VEGFR-2 and -1. Both specific and dual ATP-competitive inhibitors of VEGFR-2 were identified. Kinase selectivity could be controlled by varying the 5-carboxamide substituent at the azole ring. The most specific mols. displayed >10-fold selectivity for VEGFR-2 over VEGFR-1. Compound activities in vitro and in cell-based assays (IC50 < 100 nM) were similar to those of reported clin. and development candidates, including PTK787 (Vatalanibtrade) and ZD6474 (Vandetanib). High permeability of active compounds across the Caco-2 cell monolayer (>40×10-5 cm/min) is indicative of their potential for intestinal absorption upon oral administration.

Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 5805-53-8 belongs to class imidazoles-derivatives, name is Methyl 1H-benzo[d]imidazole-2-carboxylate, and the molecular formula is C9H8N2O2, Quality Control of 5805-53-8.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Garuti, L. published the artcileSynthesis and antiviral assays of some 2-substituted benzimidazole-N-carbamates, Application of Methyl 1H-benzo[d]imidazole-2-carboxylate, the main research area is benzimidazolecarbamate preparation antiviral activity; carbamate benzimidazole preparation antiviral activity.

The title compounds were synthesized and tested in vitro for antiviral activity. Carbamates I (R = i-PrNHCO, R1 = MeO; R = MeSCH2, R1 = i-PrO) were active at noncytotoxic concentrations The results confirmed the importance of the substituents at the 2-position of benzimidazole; an isopropylcarboxamide group led to the best activity.

Farmaco published new progress about Antiviral agents. 5805-53-8 belongs to class imidazoles-derivatives, name is Methyl 1H-benzo[d]imidazole-2-carboxylate, and the molecular formula is C9H8N2O2, Application of Methyl 1H-benzo[d]imidazole-2-carboxylate.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Garuti, Laura published the artcileSynthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles, Recommanded Product: Methyl 1H-benzo[d]imidazole-2-carboxylate, the main research area is benzimidazolyl sulfone antiviral antiproliferative preparation.

Some benzimidazolyl sulfones were synthesized and evaluated for their antiviral and antiproliferative properties. I (R = CHMe2) displayed significant and selective activity against human cytomegalovirus (CMV), I (R = 3-NO2-C6H4) showed activity against varicella zoster virus (VZV). The compounds were further evaluated for inhibitory effect on the proliferation of murine leukemia cells and human T-lymphocyte cells. Marked cytotoxicity was noted with different derivatives Some structure-activity relationships are discussed.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 5805-53-8 belongs to class imidazoles-derivatives, name is Methyl 1H-benzo[d]imidazole-2-carboxylate, and the molecular formula is C9H8N2O2, Recommanded Product: Methyl 1H-benzo[d]imidazole-2-carboxylate.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Vaultier, Michel published the artcileFormation of a 1,2,4-oxadiazoline from an aziridine: mechanism of the reaction and photochemical conversion into a benzimidazole derivative, Application In Synthesis of 5805-53-8, the main research area is aziridinedicarboxylate cleavage nitrite; phenylaziridinedicarboxylate cleavage nitrite; rearrangement photolysis phenyloxadiazoline; oxadiazoline phenyl rearrangement benzimidazole; benzimidazolecarboxylate.

Reaction of NaNO2 with the aziridine I in the presence of BzOH gave 75% oxadiazoline II, which on photolysis in C6H6 gave 86% benzimidazole III. The formation of II probably involved addition of NaNO2 to PhCH:N+PhCH(CO2Me)2 BzO-, followed by cyclization, and demethoxycarbonylation by a β-lactam path.

Journal of the Chemical Society, Chemical Communications published new progress about Photorearrangement. 5805-53-8 belongs to class imidazoles-derivatives, name is Methyl 1H-benzo[d]imidazole-2-carboxylate, and the molecular formula is C9H8N2O2, Application In Synthesis of 5805-53-8.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Alkorta, Ibon published the artcileA Theoretical Study on the Tautomerism of C-Carboxylic and Methoxycarbonyl Substituted Azoles, Product Details of C9H8N2O2, the main research area is tautomerism carboxylic methoxycarbonyl substituted azole B3LYP.

DFT calculations (B3LYP/6-31+G**) have been carried out on 106 tautomers and conformers of NH-azoles bearing CO2H and CO2CH3 groups. The following azoles systems have been studied: 2-substituted pyrroles, 2-substituted indoles, 2-substituted imidazoles, 2-substituted benzimidazoles, 4(5)-substituted imidazoles, 3(5)-substituted pyrazoles, 3-substituted indazoles (1H and 2H), 3,4(5)-substituted-1,2,3(5)-triazoles, 2,3(5)-substituted-1,2(3),4-triazoles, 4(5)-1,2,3,4(5)-tetrazoles. In the case of pyrazole, 3,5-disubstituted derivatives have also been computed, including four dimers.

Structural Chemistry published new progress about Azoles Role: PRP (Properties). 5805-53-8 belongs to class imidazoles-derivatives, name is Methyl 1H-benzo[d]imidazole-2-carboxylate, and the molecular formula is C9H8N2O2, Product Details of C9H8N2O2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Musser, J. H. published the artcileA simple one-step synthesis of alkyl benzazol-2-carboxylates, Recommanded Product: Methyl 1H-benzo[d]imidazole-2-carboxylate, the main research area is benzoxazolecarboxylate ester; cyclocondensation aminophenol trialkoxyacetate; oxalate ortho ester cyclocondensation aminophenol.

Benzoxazoles, benzothiazole derivative, and benzimidazoles I (Z = CH, N; Z1 = O, S, NH, NPh; R = Me, Et; R1 = H and R2 = H, Cl, OMe, or R1R2 = benzo) were prepared from the resp. II and (RO)3CCO2R. Thus, 2-H2NC6H4OH was treated with (MeO)3CCO2Me to give I (R = Me, Z = CH, Z1 = O, R1 = R2 = H).

Synthetic Communications published new progress about Cyclocondensation reaction. 5805-53-8 belongs to class imidazoles-derivatives, name is Methyl 1H-benzo[d]imidazole-2-carboxylate, and the molecular formula is C9H8N2O2, Recommanded Product: Methyl 1H-benzo[d]imidazole-2-carboxylate.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem