Category: 5805-52-7

Adding a certain compound to certain chemical reactions, such as: 5805-52-7, name is 1H-Benzimidazole-2-carboxamide, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5805-52-7, SDS of cas: 5805-52-7

To a solution of 9 (3.0 g, 18.6 mmol) in THF (70 mL) wasadded Lawesson?s reagent (7.5 g, 18.6 mmol). The resulting solution was stirred at 66 C for 5 h. Aftercomplete conversion of the starting material, the reaction mixture was concentrated in vacuo and theresidue was redissolved in DCM (500 mL), the solution was washed with saturated NaCl solutionthree times, dried over anhydrous sodium sulfate, concentrated and purified by flash silica gel columnchromatography (DCM:MeOH = 100:1) to obtain 10 as yellow solid in 61.2% yield. LC-MS m/z: 178.2[M + H]+.

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Reference:
Article; Wang, Shuxiang; Guan, Lihong; Zang, Jie; Xing, Kun; Zhang, Jian; Liu, Dan; Zhao, Linxiang; Molecules; vol. 24; 7; (2019);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5805-52-7, name is 1H-Benzimidazole-2-carboxamide, A new synthetic method of this compound is introduced below., Computed Properties of C8H7N3O

At room temperature, 3.0 g (18.6 mmol)1H-benzimidazole-2-carboxamide and 7.5 g (18.6 mmol)Lawson reagent placed in 250mL eggplant bottle,Add 150 mL of tetrahydrofuran to reflux at 66 C for 5 h.After the completion of the reaction, the solvent was evaporated to drynessWith methylene chloride dissolved, saturated sodium bicarbonate wash, saturated sodium chloride wash, the organic phase, anhydrous sodium sulfate drying, filtration, columnChromatography to obtain a white solid. Yield: 60.0%.

The synthetic route of 5805-52-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shenyang Pharmaceutical University; Zhao Linxiang; Liu Dan; Li Kun; Wang Shuxiang; Jing Yongkui; (21 pag.)CN106905241; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem