Category: 5805-39-0

Xiong, Yucong;Wang, Kaizhi;Ma, Lei;Zhu, Jiukang;Miao, Yujia;Gong, Li;Mu, Xiao;Wan, Jiang;Li, Rong published 《Bimetallic CoMoO₄@C nanorod catalyzes one-pot synthesis of benzimidazoles from benzyl alcohol and o-phenylendiamine without alkali》 in 2022. The article was appeared in 《Applied Organometallic Chemistry》. They have made some progress in their research.Recommanded Product: 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

Benzimidazoles possess a series of applications for industrial chem. and biomedicine. However, the complicated synthetic steps and harsh reaction conditions limit its further development. Herein, authors reported an efficient, environmentally friendly, and stable bimetallic CoMoO4@C catalyst, which used low-cost cobalt and molybdenum as the basic raw material. In base-free conditions, it has been proved that the yield could achieve to 99.9% for the synthesis of benzimidazoles with liberating water as the sole byproduct, and the catalyst remains stable and efficient even after five successive cycle tests. Addnl., experiments and characterizations confirm the good oxidation activity of the catalyst benefits from the numerous oxygen vacancies provided by the high concentration of low-valent cobalt (Co²⁺) and the doping of carbon improves the intermol. transport of electrons. Furthermore, this strategy could potentially be applied in the industrial production of benzimidazoles. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Recommanded Product: 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Product Details of 5805-39-0《Microwave Assisted Green Synthesis of Benzimidazole Derivatives and Evaluation of Their Anticonvulsant Activity》 was published in 2019. The authors were Sahoo, Biswa Mohan;Banik, Bimal Krishna;Mazaharunnisa;Rao, Naidu Srinivasa;Raju, Bodapati, and the article was included in《Current Microwave Chemistry》. The author mentioned the following in the article:

N-(Benzimidazolylphenyl)cinnamides I (R = Ph, 2-ClC₆H₄, 4-ClC₆H₄, 4-FC₆H₄, 4-HC₆H₄) are synthesized by reaction between ortho-phenylene diamine and anthranilic acid followed by acetylation in the presence of acetic anhydride and Claisen-Schmidt condensation with substituted benzaldehydes RCHO. Both conventional and microwave irradiation technol. are followed to get the titled compounds I. The titled compounds are screened for their anticonvulsant activity and neurotoxicity. By the help of microwave synthesis, the yield of product was increased in less reaction time. So, it follows Green chem. approach by making above reactions eco-friendly. Some of the compounds exhibited significant anticonvulsant activity as compared to standard drug. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Product Details of 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Name: 2-(1H-Benzo[d]imidazol-2-yl)anilineIn 2021, Li, Jia-Bin;Zheng, Han-Wen;Wu, Min;Liang, Qiong-Fang;Yang, Dong-Dong;Zheng, Xiang-Jun;Tan, Hong-Wei published 《Multistimulus Response of Two Tautomeric Zn(II) Complexes and Their White-Light Emission Based on Different Mechanisms》. 《Inorganic Chemistry》published the findings. The article contains the following contents:

A triphenylamine (TPA)-based 2H-quinazoline Zn(II) complex (Q-TPA-Zn) exhibiting dual fluorescence and phosphorescence emission in the solid state was designed and prepared It possesses mechanochromic luminescence and thermochromic luminescence properties. In the solid state, the white afterglow luminescence could be observed at 77 K (CIE_xy: 0.27, 0.33) while cyan luminescence could be observed at 297 K. After thermolysis at 300 °C, Q-TPA-Zn could be transformed into Schiff base complex S-TPA-Zn with white fluorescence in the powder state (CIE_xy: 0.32, 0.38), in methanol (CIE_xy: 0.32, 0.39), and in DMF (CIE_xy: 0.26, 0.32) at room temperature This arises from dual emission of normal* emission and tautomeric* emission induced by excited-state intramol. proton transfer (ESIPT) from the benzimidazole NH group to the Schiff base N atom. Q-TPA-Zn could also be transformed into its isomeric form, S-TPA-Zn, through photochem. ring-opening reaction upon irradiation under 365 nm in the solution, exhibiting high-contrast photochromic luminescence. Interestingly, S-TPA-Zn could further be transformed into its zwitterionic isomer after continuous irradiation The same ring-opening reaction could also take place for the organic compound Q-TPA via heating or 365 nm irradiation The ring-opening reaction mechanism and ESIPT emission were interpreted via theor. calculation To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Name: 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Khan, Salman A.;Ullah, Qasim;Parveen, Humaira;Mukhtar, Sayeed;Alzahrani, Khalid Ahmed;Asad, Mohammad published 《Synthesis and photophysical investigation of novel imidazole derivative an efficient multimodal chemosensor for Cu(II) and fluoride ions》. The research results were published in《Journal of Photochemistry and Photobiology, A: Chemistry》 in 2021.SDS of cas: 5805-39-0 The article conveys some information:

Aminophenylbenzimidazole derivative of theonyl trifluoro acetone has been designed, synthesized and characterized to sense Cu(II) and fluoride ions. The probe showed very selective colorimetric and ratiometric fluorescence changes with copper(II), turn-on fluorescence behavior with fluoride ions. ESI-MS anal. and jobs plots anal. provided the information about the interaction mode between Cu(II) and the probe. D. functional theory calculations carried out on the probe with/without Cu(II) and fluoride ions to support the observed photophys. changes. The Probe can be utilized to detect Cu(II) ions via electrochem. detection and hence it can be used to detect copper ions by multiple modes. The fluorescence and absorbance change with fluoride ions showing that the probe is very sensitive towards fluoride ions among other anions. The detection limits for the detection of Cu(II) and fluoride ions were found to be 23 nM and 0.54 nM resp. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 SDS of cas: 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

COA of Formula: C13H11N3《Synthesis, characterization, X-ray crystal structures of heterocyclic Schiff base compounds and in vitro cholinesterase inhibition and anticancer activity》 was published in 2017. The authors were Arafath, Azharul Md.;Adam, Farook;Al-Suede, Fouad Saleih R.;Razali, Mohd. R.;Ahamed, Mohamed B. Khadeer;Abdul Majid, Amin Malik Shah;Hassan, Mohd. Zaheen;Osman, Hasnah;Abubakar, Saifullah, and the article was included in《Journal of Molecular Structure》. The author mentioned the following in the article:

Four heterocyclic embedded Schiff base derivatives, (benzimidazo[1,2-c]quinazolin-6-yl)methoxyphenol I and II [R = 3-OH-4-OMe, 2-OH-5-OMe; R¹ = 5-methyl-2-pyridyl, 2-(1,3-benzothiazol-2-yl)phenyl] were synthesized and characterized by m.p., elemental anal., FTIR, ¹H, ¹³C NMR and UV-visible spectral data. The structures of compounds I and II [R = 2-OH-5-OMe, R¹ = 5-methyl-2-pyridyl; 3-OH-4-OMe, 2-(1,3-benzothiazol-2-yl)phenyl] were successfully established through single crystal X-ray diffraction anal. In-vitro cholinesterase inhibition assays showed that the cyclized derivative I displayed higher BuChE enzyme inhibitory activity with IC₅₀ value of 1.45 ± 0.09 μM. The anti-proliferative efficacies of the compounds were also evaluated using human colorectal HCT 116 and breast MCF-7 adenocarcinoma cell lines. In addition, a human normal endothelial cell line (Ea.hy926) was also tested to assess the safety and selectivity of the compounds towards normal and cancer cells, resp. Among the compounds tested, compound II [R = 3-OH-4-OMe, 2-(1,3-benzothiazol-2-yl)phenyl] displayed potent cytotoxic effect (IC₅₀ = 34 μM) against HCT 116 cells with highest selectivity index of 3.1 with respect to the normal endothelial cells. Whereas, compound II [R = 2-OH-5-OMe, R¹ = 5-methyl-2-pyridyl] exhibited significant anti-proliferative effect (IC₅₀ = 21.1 μM) against MCF-7 cells with highest selectivity index of 3.3 with respect to the normal endothelial cells. The docking result of these compounds against hAChE showed potent activities with different binding modes. These compounds could be a promising pharmacol. agent to treat cancer and Alzheimer’s disease. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 COA of Formula: C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem