Category: 5805-39-0

Application In Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)aniline《An efficient green synthesis of 5H-spiro[benzo[4,5]imidazo[1,2-c]quinazoline-6,3′-indolin]-2′-ones catalyzed by iodine in ionic liquids》 was published in 2017. The authors were Zhang, Mei-Mei;Wang, Yue;Liu, Jian-Quan;Wang, Xiang-Shan, and the article was included in《Heterocyclic Communications》. The author mentioned the following in the article:

Benzene-1,2-diamine was treated with 2-nitrobenzaldehyde in EtOH, and the product was reduced with hydrazine hydrate in the presence of Fe(C) without separation to give 2-(1H-benzo[d]imidazol-2-yl)aniline. Reactions of compound 2-(1H-benzo[d]imidazol-2-yl)aniline with isatins in the presence of iodine in an ionic liquid furnished 5H-spiro[benzo[4,5]imidazo[1,2-c]quinazoline-6,3′-indolin]-2′-ones I [R= H, 5′-Me, 4′-Cl, 6′-Br, 7′-F, etc.] in high yields.2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) were involved in the experimental procedure.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Application In Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Fu, Qing-Qing;Hu, Jing-Han;Yao, Ying;Yin, Zhi-Yuan;Gui, Kai;Xu, Nuo;Niu, Li-Yi;Zhang, Yu-Qing published 《A benzimidazole derivative based LMCT sensor for the detection of Cu²⁺ in DMSO/H₂O (2:3 v/v) solution and its application in implication logic gates》. The research results were published in《Journal of Photochemistry and Photobiology, A: Chemistry》 in 2020.Application In Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)aniline The article conveys some information:

Reversible dual channel sensor F2 for detection Cu²⁺ is designed and synthesized. F2 is substantially unaffected by other cationic ions during the recognition of Cu²⁺. It is worth noting that the low detection limit of sensor F2 is 9.09 × 10^-9, and the detection limit is lower that to the reported sensor for identifying Cu²⁺. Through various experiments and characterization, it is proved that ligand-metal charge transfer (LMCT) is the interaction mechanism between F2 and Cu²⁺. It is further certified that the stoichiometry between F2 and Cu²⁺ is 1:1. In addition, the fluorescence changes of F2 upon the addition of Cu²⁺ and EDTA are applied as an ultrasensitive IMPLICATION logic gate at the mol. level. At the same time, mol. keyboard experiments have achieved information protection at the mol. level. More importantly, the test strips containing F2 can be easily and quickly tested to achieve on-site inspection.2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) were involved in the experimental procedure.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Application In Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Odame, F.;Hosten, Eric C.;Betz, R.;Krause, J.;Frost, Carminita L.;Lobb, K.;Tshentu, Zenixole R. published 《Synthesis, characterization, computational studies and DPPH scavenging activity of some triazatetracyclic derivatives》 in 2021. The article was appeared in 《Journal of the Iranian Chemical Society》. They have made some progress in their research.SDS of cas: 5805-39-0 The article mentions the following:

Some dihydrobenzo[4,5]imidazo[1,2-c]quinazolines I (R = Me, 2-methylpropyl, Ph, etc.; R¹ = H, Me) have been synthesized from aldehydes RCHO and ketones RC(O)CH₃, using the ketones as both reagents and solvents and THF (THF) as the solvent for the aldehydes, to yield the triazatetracyclics I. The compounds I have been characterized with spectroscopy and microanal. The crystal structures of triazatetracyclics I [R = Me, R¹ = Me (II); R = Et, R¹ = Me (III); and R = Ph, R¹ = H (IV)] have been discussed. The computed NMR, IR, mol. electrostatic potential and frontier MOs of compounds II, III and IV have been discussed. The M06 functional gave most of its values closest to the exptl. values for the bond lengths and bond angles of compounds II and III. For compound IV, none of the functionals gave values for bond lengths and bond angles that were consistent with the exptl. values, but M06 gave values closest to exptl. values. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity of the triazatetracyclics showed that compound II exhibits significant DPPH scavenging activity with an IC₅₀ of 56.18μM compared to 2.37μM for ascorbic acid. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 SDS of cas: 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Iniya, Murugan;Vidya, Balasubramanian;Anand, Thangaraj;Sivaraman, Gandhi;Jeyanthi, Dharmaraj;Krishnaveni, Karuppiah;Chellappa, Duraisamy published 《Microwave-Assisted Synthesis of Imidazoquinazoline for Chemosensing of Pb²⁺ and Fe³⁺ and Living Cell Application》. The research results were published in《ChemistrySelect》 in 2018.COA of Formula: C13H11N3 The article conveys some information:

An efficient dual-responsive fluorescent probe based on imidazoquinazoline has been synthesized using microwave-assisted solvent-free condition. Its sensing behavior towards Pb²⁺ and Fe³⁺ has been investigated sep. through fluorescence, absorbance and visual fluorescence color changes in different solvent systems. Interestingly, the binding event triggers selective “turn-on” response to Pb²⁺ and ratiometric response to Fe³⁺ against other commonly coexistent metal ions. The observed exptl. data has been rationalized in terms of theor. calculations The living cell imaging experiment demonstrated the practical value of the sensor in mapping intracellular Fe³⁺ and Pb²⁺ distributions in biol. systems. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 COA of Formula: C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Si, Wei-Jie;Wang, Xiao-Bin;Chen, Min;Wang, Meng-Qi;Lu, Ai-Min;Yang, Chun-Long published 《Design, synthesis, antifungal activity and 3D-QSAR study of novel pyrazole carboxamide and niacinamide derivatives containing benzimidazole moiety》 in 2019. The article was appeared in 《New Journal of Chemistry》. They have made some progress in their research.Reference of 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

A series of novel pyrazole carboxamide I (R¹ = H, Cl, Me; R² = Me, CF₃), II (R¹ = H, Cl, Me; R² = Me, i-Bu) and niacinamide derivatives III (R¹ = H, Cl, Me; R² = H, Cl, SH) containing a benzimidazole moiety were designed and synthesized as antifungal candidate agents. The structure of compound I (R¹ = H; R² = Me) was confirmed by single crystal X-ray diffraction anal. The antifungal activities of the target compounds were evaluated in vitro against four phytopathogenic fungi (namely Botrytis cinerea, Rhizoctonia solani, Fusarium graminearum and Alternaria solani) by the mycelium growth inhibition method. The bioassay results indicated that some of the compounds exhibited good antifungal activity against B. cinerea at 100 μg ML^-1 compared to other three fungi. In order to better explore the structure-activity relationship (SAR), the EC₅₀ values of target compounds against B. cinerea were measured and assessed. Subsequently, a 3D quant. structure-activity relationship (3D-QSAR) study was carried out using the comparative mol. field anal. (CoMFA) technique based on the inhibitory activities of tested compounds against B. cinerea. Mol. modeling results revealed fine predictive ability with cross-validated q² and non-cross-validated r² values of 0.578 and 0.850, resp. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Reference of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Odame, F.;Hosten, E. C.;Tshentu, Z. R. published 《Synthesis,characterization and computational studies of N-[(9E)-8,10,17-triazatetracyclo[8.7.0.0^2,7.0^11,16]heptadeca-1(17),2,4,6,11(16),12,14-heptaen-9-ylidene] benzamide》 in 2020. The article was appeared in 《Journal of Structural Chemistry》. They have made some progress in their research.SDS of cas: 5805-39-0 The article mentions the following:

N-[(9E)-8,10,17-Triazatetracyclo[8.7.0.0^2,7.0^11,16]heptadeca-1(17),2,4,6,11(16),12,14-heptaen-9-ylidene] benzamide (I) is synthesized and characterized by spectroscopy, microanal., and single crystal X-ray diffractometry. Compound I crystallizes in the monoclinic space group P2₁/c with a = 15.8980(7) Å, b = 4.8067(2) Å, c = 21.0455(10) Å, β = 101.153(2)°, and Z = 4. The exptl. bond lengths and bond angles are contrasted with computed bond lengths and bond angles.2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) were involved in the experimental procedure.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 SDS of cas: 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Jeyanthi, D.;Joel, C.;Bennie, R. Biju;Livingston, D. Jim;Balakrishnan, C. published 《Crystal structure and chemosensing property of benzimidazole-based probe towards detection of multiple analytes – A combined experimental and DFT approach》 in 2022. The article was appeared in 《Journal of Photochemistry and Photobiology, A: Chemistry》. They have made some progress in their research.Name: 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

A benzimidazole derived probe [(6-(1H-indol-3-yl)-5,6-dihydrobenzo[4,5]imidazo [1,2-c]quinazoline) (IDBIQ)] was synthesized and structurally characterized by single-crystal X-ray diffraction anal. and spectroscopic methods. The probe IDBIQ crystallizes in a monoclinic P2_1/c space group which is found to be highly sensitive and also selective towards the analytes Hg^II, F^– and histidine. The probe exhibits turn-off fluorescence for Hg^II and histidine while it is ratiometric towards F^– ions. These quenching and ratiometric fluorescent changes have been further explored by ¹H NMR titrations and DFT/TD-DFT calculations The limit of detection of the probe towards the analytes was found to be in nano-molar range and the receptor was observed to bind with the analytes in 1:1 stoichiometric manner. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Name: 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 5805-39-0In 2018, Chen, Dong-Sheng;Liu, Shu-Jun;Lu, Wen-Qiang;Wang, Xiang-Shan published 《Green synthesis of 6-aryl-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline derivatives in ionic liquid under catalyst-free conditions》. 《Journal of Heterocyclic Chemistry》published the findings. The article contains the following contents:

Using ionic liquids as green media, a series of 6-arylbenzimidazolo[1,2-c]quinazoline derivatives I [R¹ = 3-Cl, 4-Br, 3,5-(MeO)₂, etc.] was synthesized via reaction of 2-(1H-benzo[d]imidazol-2-yl)aniline and benzaldehydes in the air. The intermediate products of 6-arylbenzimidazolo[1,2-c]quinazolines II [R² = 2,4-Cl₂, 2-Br, 3,5-(MeO)₂, etc.] were obtained in high yields at the same conditions under nitrogen protection. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Application of 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kanlayakan, Narissa;Kungwan, Nawee published 《Theoretical study of heteroatom and substituent effects on excited-state intramolecular proton transfers and electronic properties of amino-type hydrogen bonding molecules》 in 2021. The article was appeared in 《Journal of Luminescence》. They have made some progress in their research.Application In Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

Excited-state intramol. proton transfer (ESIPT) reactions and electronic properties of the NH-type hydrogen bonding mols. (APBI, APBO, APBT, and APIP) and their derivatives have been theor. investigated. For the different heteroatoms at the same position, the oxygen (APBO) and sulfur (APBT) bring weak intra-HB leading to only normal emission while the nitrogen (APBI) makes moderatly strong intra-HB in APBI giving dual emission. For the nitrogen heteroatoms at the different positions, the tertiary nitrogen in APIP greatly enhances intramol. charge transfer (ICT) resulting in a tautomer emission maximum (driven by ESIPT) at much longer wavelength compared to that of APBI with secondary nitrogen. Moreover, the introduction of a tosyl (Ts) into one of amino protons of the NH-type mols. yielding Ts-substituted derivatives can ensure their ESIPT providing a single tautomer emission. Furthermore, the addition of a moderatly strong electron withdrawing group (cyano) in tosylaminophenyl causes a slight blue-shift of the tautomer emission maximum while the addition of a moderatly strong electron donating group (amino) makes a noticeable red-shift of the emission maximum compared to their parents. Among the designed derivatives, APIP-tosyl-NH2 photoexcited at around 360 nm exhibits the longest wavelength of tautomer emission in near IR region caused by strong ICT leading to large Stokes shift that can avoid self-reabsorption which is an important character for fluorescent probes.2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) were involved in the experimental procedure.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Application In Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Odame, F.;Hosten, E. C.;Tshentu, Z. R. published 《Synthesis, Characterization, and Computional Studies of Triazatetracyclo Acetamide》 in 2018. The article was appeared in 《Journal of Structural Chemistry》. They have made some progress in their research.Recommanded Product: 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

N-[(9E)-8,0 10,0 17-triazatetracyclo[8.7.0.0^2,7.0^11,18]heptadeca-1(17),2(7),3,5,11,13,15-heptaen-9-ylidene] acetamide (I) was synthesized and characterized by spectroscopy, microanal., and single crystal X-ray diffractometry. Compound I crystallizes in the monoclinic space group P21/n with a = 17.5552(17) Å, b = 4.6163(4) Å, c = 17.7662(17) Å, β = 115.953(3)°, and Z = 4. The bond angles and bond lengths of the compound are computed using the d. functional theory with B3LYP, BPW91, and wB97XD functionals and the 6-31G++(d,p) basis set. The frontier orbitals that contribute to the reactivity of triazatetracyclics were discussed. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Recommanded Product: 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem