Category: 5805-39-0

Hasan, Hiba Ali;Abdulmalek, Emilia;Abdul Rahman, Mohd Basyaruddin;Shaari, Khozirah Binti;Yamin, Bohari Mohd.;Chan, Kim Wei published 《Microwave synthesis, crystal structure, antioxidant, and antimicrobial study of new 6-heptyl-5,6-dihydrobenzo[4,5]imidazo[1,2-c] quinazoline compound》 in 2018. The article was appeared in 《Chemistry Central Journal》. They have made some progress in their research.Synthetic Route of C13H11N3 The article mentions the following:

A comparative study between two methods, (microwave-assisted and conventional heating approaches), was performed to synthesize a new quinazoline derivative from 2-(2-aminophenyl)-1H-benzimidazole and octanal to produce 6-heptyl-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline (OCT). The compound was characterised using FTIR, ¹H and ¹³C NMR, DIMS, as well as X-ray crystallog. The most significant peak in the ¹³C NMR spectrum is C-7 at 65.5 ppm which confirmed the cyclization process. Crystal structure anal. revealed that the mol. growed in the monoclinic crystal system P2₁/n space group and stabilized by an intermol. hydrogen bond between the N1-H1A···N3 atoms. The crystal packing anal. showed that the mol. adopts zig-zag one dimensional chains. Fluorescence study of OCT revealed that it produced blue light when expose to UV-light and its quantum yield equal to 26%. Antioxidant activity, which included DPPH· and ABTS^·+ assays was also performed and statistical anal. was achieved via a paired T-test using Minitab 16 software with P < 0.05. Also, the antimicrobial assay against two Gram-pos., two Gram-neg., and one fungus was screened for these derivatives Using microwave to synthesize OCT have drastically reduced reaction time, and increased yield. OCT showed good antioxidant activity in one of the tests and moderate antimicrobial activity. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Synthetic Route of C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

HPLC of Formula: 5805-39-0In 2019, Hu, Wangqin;Yang, Wen;Gong, Tingfeng;Zhou, Weiqun;Zhang, Yuhan published 《Multi-stimuli responsive properties switch by intra- and inter-molecular charge transfer constructed from triphenylamine derivative》. 《CrystEngComm》published the findings. The article contains the following contents:

Combining triphenylamine (TPA) and 2-(1H-benzo[d]imidazol-2-yl) aniline (BI), a typical fluorescent dye, TPA-BI, was designed and synthesized. The photo-phys. properties of this compound were investigated both in solution and the solid state. TPA-BI showed a strong AIEE effect and its relative fluorescence quantum yield (φ_f) was up to 63.4% in the aggregation state. The tunable fluorescence phenomenon by the MCF effect was observed between the amorphous (bluish violet) and crystalline (green) states, and the absolute φ_f was determined to be 56.2% and 21.9%, resp., by the integral sphere method. Meanwhile, pH titration experiments exhibited the tunable fluorescence phenomenon in different pH solutions Thus, TPA-BI could also be used as a fluorescent switch from green to bluish-violet based on its response to volatile acidic and alk. organic compounds in the solid state repeatedly without fatigue and destruction under UV illumination (365 nm), which can be explained by the reversible transformation by protonation and deprotonation. The protonation process was further confirmed in detail by ¹HNMR titration experiments D. functional theory (DFT) and time-dependent d. functional theory (TD-DFT) were used to predict the multi-stimuli responsive fluorescence properties. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 HPLC of Formula: 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Category: imidazoles-derivatives《High accuracy machine learning identification of fentanyl-relevant molecular compound classification via constituent functional group analysis》 was published in 2020. The authors were Xu, Mengyu;Wang, Chun-Hung;Terracciano, Anthony C.;Masunov, Artem E.;Vasu, Subith S., and the article was included in《Scientific Reports》. The author mentioned the following in the article:

Fentanyl is an anesthetic with a high bioavailability and is the leading cause of drug overdose death in the U. S. Fentanyl and its derivatives have a low LD and street drugs which contain such compounds may lead to death of the user and simultaneously pose hazards for first responders. Rapid identification methods of both known and emerging opioid fentanyl substances is crucial. In this effort, machine learning (ML) is applied in a systematic manner to identify fentanyl-related functional groups in such compounds based on their observed spectral properties. In our study, accurate IR (IR) spectra of common organic mols. which contain functional groups that are constituents of fentanyl is determined by investigating the structure-property relationship. The average accuracy rate of correctly identifying the functional groups of interest is 92.5% on our testing data. All the IR spectra of 632 organic mols. are from National Institute of Standards and Technol. (NIST) database as the training set and are assessed. Results from this work will provide Artificial Intelligence (AI) based tools and algorithms increased confidence, which serves as a basis to detect fentanyl and its derivatives The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Category: imidazoles-derivatives) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 5805-39-0《Benzimidazolyl based Schiff base palladium complex in an ionic liquid: an effective combination for Suzuki coupling》 was published in 2017. The authors were Basappa Chidananda, Vasantha Kumar;Ramakrishna, Dileep;Kaur, Manpreet;Hosakere Doddarevanna, Revanasiddappa, and the article was included in《Journal of Coordination Chemistry》. The author mentioned the following in the article:

A new benzimidazole based Pd(II) Schiff base complex (I) was prepared and its catalytic activity was evaluated for Suzuki cross-coupling reactions in ethyl-Me imidazolium hexafluorophosphate [EMIM PF₆] ionic liquid at ambient temperature The system provides a stable and reusable method for coupling reactions. Optimization for suitable reaction conditions were studied with respect to the effect of catalyst concentration, effects of additives, solvent and substituents on boronic acid. Good to excellent yields were achieved using a modest amount of the catalyst. The reaction time was less and the yield was more compared to previously reported results. In addition, the catalyst can be easily reused and recycled for six times without much loss in activity; this is an example of sustainable and green methodol. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Related Products of 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Recommanded Product: 5805-39-0《4-Chloro-2-(5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazolin-6-yl)phenol (HL); synthesis, characterization, crystal structure, Hirshfeld surface analysis and BSA binding studies》 was published in 2018. The authors were Kumar, B. C. Vasantha;K, Savithri;Chandra;Kaur, Manpreet;Jasinski, Jerry P.;Revanasiddappa, H. D., and the article was included in《Journal of Molecular Structure》. The author mentioned the following in the article:

A new asym. bidentate Schiff-base mol. 4-chloro-2-(5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazolin-6-yl)phenol (HL), has been synthesized and characterized using physicochem. and spectroscopic techniques, single crystal X-ray diffraction and Hirshfeld surface anal. Crystal structure anal. reveals that the compound crystallized in the orthorhombic system in the Pbca space group. The in vitro interactions of the synthesized compound, with bovine serum albumin was thoroughly investigated using UV-Vis absorption in combination with fluorescence quenching techniques, and these methods were used to determine the binding parameters also the mechanism of interaction behind the new compound HL bound to BSA. Values of the binding constants (K_b) were about ∼105 M^-1 signifying a moderate interaction between HL and BSA making the protein suitable for transportation and delivery of the compound Thermodn. parameters also revealed binding through weak van der Waals forces and hydrogen bonding interactions of HL to BSA. The results obtained from docking studies were consistent and complemented those derived from other exptl. studies. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Recommanded Product: 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Xie, Caixia;Zhang, Zeyuan;Li, Danyang;Gong, Jian;Han, Xushuang;Liu, Xuan;Ma, Chen published 《Dimethyl Sulfoxide Involved One-Pot Synthesis of Quinoxaline Derivatives》. The research results were published in《Journal of Organic Chemistry》 in 2017.Synthetic Route of C13H11N3 The article conveys some information:

An efficient, green, and novel method for the synthesis of N-heterocycle-fused quinoxalines is reported herein. DMSO was used as both a reactant and a solvent in this reaction. A wide range of products in moderate to excellent yields were obtained, including pyrrolo[1,2-a]quinoxalines, indolo[1,2-a]quinoxalines, 1H-pyrrolo[3,2-c]quinolines, and benzo[4,5]imidazo[1,2-c]quinazolines. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Synthetic Route of C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Category: imidazoles-derivativesIn 2019, Li, Jia-Bin;Liu, Yang;Zheng, Xiang-Jun;Wang, Dan published 《An off-on chemosensor for Hg²⁺ based on the excimer emission of anthracene》. 《Microchemical Journal》published the findings. The article contains the following contents:

A quinazoline derivative 6-anthracenyl-5,6-2H-benzimidazo[1,2-c]quinazoline (L) was obtained and characterized by elemental anal., IR spectroscopy, ¹H NMR and single-crystal X-ray diffraction. L shows very weak emission in DMSO, but can respond to Hg²⁺ ion intensively in off-on mode. Job’s plot and titration experiments show that Hg²⁺ ion binds L in 1:1 stoichiometry. The detection limit for Hg²⁺ is 6.34μM. ¹H NMR titration experiments indicate that only one benzimidazo nitrogen atom coordinates with Hg2+. And the fluorescence emission spectra imply that an excimer formed in the Hg²⁺-L system, and the detection of Hg²⁺ was realized by excimer emission of anthracene moiety. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Category: imidazoles-derivatives) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Shaikh, Irfan N.;Bagwan, Umar Farooq;Hunagund, Shirajahammad M.;Shaikh, Imran N.;Afzal, Mohammed published 《Cu-catalyzed Rapid Synthesis of Novel Fluorinated Indole Derivatives Under Microwave Irradiation》 in 2018. The article was appeared in 《Chemistry Africa》. They have made some progress in their research.Product Details of 5805-39-0 The article mentions the following:

Herein, a simple microwave-assisted synthesis of novel fluorinated indole derivatives I [R = (1H-benzimidazol-2-yl)phenyl, 6-chloro-7H-purin-2-yl, 3-amino-2,2-dimethyl-3-phenylpropyl, etc.] have been developed by the reaction of 5-fluoroindoline-2,3-dione with various anilines RNH₂. The reaction could be conducted using readily available substrates within short periods of 9-15 min under microwave irradiation with good to excellent yields of the product (64-92%). This approach exploits the synthetic potential of microwave irradiation and copper dipyridine dichloride (CuPy₂Cl₂) combination and offers many advantages such as full reaction control, excellent product yields, shorter reaction time, eco-friendly procedure and rapid feedback. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Product Details of 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Odame, Felix;Hosten, Eric C. published 《Synthesis, characterization and computational studies of two triazaspiro tetracycles》 in 2018. The article was appeared in 《Acta Chimica Slovenica》. They have made some progress in their research.Reference of 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

Synthesis of two new triazaspiro tetracycles I (R = 3-Me, 4-Me) and their characterization using spectroscopy, microanal. and single crystal X-ray diffractometry are discussed. The DFT computed bond angles were obtained for both compounds and compared to exptl. results for the compound I (R = 4-Me). The HOMO-LUMO anal. of both compounds has been carried out. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Reference of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sharada, Duddu S.;Shinde, Anand H.;Patel, Srilaxmi M.;Vidyacharan, Shinde published 《Scaffold Diversity through a Branching Double-Annulation Cascade Strategy: Iminium-Induced One-Pot Synthesis of Diverse Fused Tetrahydroisoquinoline Scaffolds》 in 2016. The article was appeared in 《Journal of Organic Chemistry》. They have made some progress in their research.Synthetic Route of C13H11N3 The article mentions the following:

A branching double-annulation cascade (BDAC) strategy for diverse and complex fused THIQ scaffolds via a highly reactive iminium-induced one-pot double-cyclization sequence involving Pictet-Spengler-type cyclization has been developed for the first time. The salient features of this protocol are that it allows direct and rapid access to unprecedented diverse fused THIQ skeletons, is metal/catalyst free, has a cleaner reaction profile, provides good to excellent yields, and is a convenient approach. This catalyst-free domino process facilitates the double annulation with a variety of scaffold building agents via two C-N and one C-X (X = C, N, O) bond formation in a single step under uniform reaction conditions. Furthermore, we reveal an unusual dual BDAC sequence leading to N-N-linked isoquinoline dimer. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Synthetic Route of C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem