Category: 5805-39-0

Recommanded Product: 2-(1H-Benzo[d]imidazol-2-yl)anilineIn 2020, Annan, Neveen A.;Butler, Ian S.;Osman, Yehia A.;Hussein, Mervat H.;Jean-Claude, Bertrand J.;Saad, Eman M.;Mostafa, Sahar I. published 《Complexes based N,N-donors (2,2′-bipyridyl & 2-(2-aminophenyl)benzimidazole); Synthesis, characterization, DNA interaction and toxicity assessment against Chlorella vulgaris microchlorophyte; X-ray crystal structure of [Zn(bpy)₃]Cl₂》. 《Inorganica Chimica Acta》published the findings. The article contains the following contents:

The syntheses of some N,N-donors, 2,2′-bipyridyl (bpy) and 2-(2-aminophenyl)benzimidazole (HAPB) complexes are reported. The structures of the complexes are discussed on the bases of their IR, NMR (¹H, ¹³C, ³¹P), UV-visible, and EI and maldi-mass spectra, elemental analyses, molar conductivities and TGA behavior. HAPB coordinates to the central metal ions in neutral monodentate {[Au(HAPB)Cl₃], cis-[MoO₂(HAPB)(DMF)Cl₂], [Pd(HAPB)(H₂O)Cl₂], [M(HAPB)(PPh₃)Cl₂] and [Pd(bpy)(HAPB)Cl]Cl} or bidentate {[Zn(HAPB)₂](ClO₄)₂, [Zn(PPh₃)(HAPB)Cl₂(H₂O)], [Ag(L)(HAPB)]NO₃ (L = bpy, PPh₃), [M(HAPB)Cl₂] (M(II) = Pd, Pt), [Rh(HAPB)₂Cl₂]Cl and [Rh(PPh₃)(HAPB)Cl]Cl₂} fashion, via the imidazole N- atom or both amino N- and imidazole N-atoms, resp. The X-ray crystal structure of the complex, [Zn(bpy)₃]Cl₂, was determined It was crystallized in a monoclinic lattice with space group symmetry P_2/n. The Zn(II) ion is coordinated in a distorted octahedral geometry by the two nitrogen atoms of three bpy moieties in the expected neutral bidentate fashion. The stoichiometries and the formation constants of Pd(II), Pt(II), [M(L)Cl₂] (L = bpy, 2PPh₃) complexes were determined using both Job’s and the molar ratio methods. The DNA-binding constants of some of the complexes were calculated based on UV-visible spectroscopy. The results indicate intercalative CT-DNA binding in view of their hypochromism and low-to-moderate binding abilities. The DNA binding abilities of the complexes follow the order [Pd(PPh₃)(HAPB)Cl₂] > [Pt(HAPB)Cl₂] > [Pd(HAPB)(H₂O)Cl₂] > [Pd(HAPB)Cl₂], which may result from steric hindrance around the metal ions comes from HAPB with bpy or PPh₃ chelates. Moreover, the toxicity of HAPB and its Pd(II) complexes against the microchlorophyte (Chlorella vulgaris) were assessed. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Recommanded Product: 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Liang, Danqing;Ming, Jin;Li, Li;Mohammadnia, Majid published 《Preparation and characterization of Cu supported on 2-(1H-benzo[d]imidazol-2-yl)aniline-functionalized Fe₃O₄ nanoparticles as a novel magnetic catalyst for Ullmann and Suzuki cross-coupling reactions》. The research results were published in《Applied Organometallic Chemistry》 in 2020.Recommanded Product: 5805-39-0 The article conveys some information:

Copper supported on 2-(1H-benzo[d]imidazol-2-yl)aniline (BIA)-functionalized Fe₃O₄ nanoparticles (Cu-BIA-Si-Fe₃O₄) as a novel magnetic catalyst was designed and used for the synthesis of new products via Ullmann and Suzuki cross-coupling reactions. The Ullmann reaction was performed by mixing arylboronic acid with aniline derivatives in dimethylsulfoxide solvent. Also, diaryls were synthesized via Suzuki C-C reactions between aryl halides and phenylboronic acid in the same solvent. The prepared materials and catalyst were characterized with various anal. techniques. The Cu-BIA-Si-Fe₃O₄ catalyst demonstrated catalytic efficiency with good to excellent yields for both types of reactions in comparison with com. palladium catalysts. Also, the catalyst could be recovered by a simple filtration and retained its activity even after several cycles. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Recommanded Product: 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Muslim, Mohd;Faizi, Serajul Haque Md.;Ali, Arif;Afzal, Mohd;Ahmad, Musheer;Dege, Necmi;Mashrai, Ashraf published 《Crystal structure and Hirshfeld surface analysis of [2-(1H-benzimidazol-2-yl-κN³)aniline-κN]dichloridozinc(II) N,N-dimethylformamide monosolvate》 in 2021. The article was appeared in 《Acta Crystallographica, Section E: Crystallographic Communications》. They have made some progress in their research.Reference of 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

The title compound, [ZnCl₂(C₁₃H₁₁N3)]·C₃H₇NO, crystallized in the monoclinic crystal system in space group P2₁/n. The asym. unit contains one neutral complex mol., which consists of a zinc ion, a bidentate ligand, and two chlorido ligands with DMF monosolvate. The ligand has two moieties, a benzimidazole and an aniline group. The benzimidazole and aniline planes are not coplanar, subtending a dihedral angle of 18.24 (8)°. The Zn(II) ion shows distorted tetrahedral geometry, being coordinated by an imidazole N atom, the aniline N atom, and two chlorido ligands. The packing features N-H···O, N-H···Cl, C-H···Cl hydrogen bonding. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Reference of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Nawrot, I.;Czerwinska, Katarzyna;Machura, B.;Kruszynski, R. published 《Synthesis, structural diversity and luminescent properties of cadmium(II) coordination assemblies with 2-(2-aminophenyl)-1H-benzimidazole and pseudohalide ions》 in 2017. The article was appeared in 《Journal of Luminescence》. They have made some progress in their research.Name: 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

A systematic investigation of Cd(II)-(apbim)-X systems (apbim=2-(2-aminophenyl)-1H-benzimidazole and X=N^–₃,SCN^– and N(NC)^–₂) was conducted, and the following cadmium(II) coordination compounds [Cd(N₃)₂(apbim)]_n•nMeOH (1), [Cd(SCN)₂(apbim)]_n•nMeOH (2), [Cd(dca)(apbim)₂]_n•n(NO₃) (3), [Cd(SCN)₂(apbim)₂] (4) and [Cd(dca)₂(apbim)₂]•H₂O (5) were successfully synthesized and characterized by single-crystal diffraction, X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) anal. and IR spectroscopy. The luminescent properties of 2-(2-aminophenyl)-1H-benzimidazole and cadmium(II) coordination compounds were studied in solution (4 and 5) and solid state (1-5). The studies revealed that the solid state architecture and solid state photoluminescent properties of the Cd(II)-apbim-X systems (X=N₃, NCS^– and dca^–) are strongly influenced by intermol. interactions. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Name: 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of C13H11N3In 2021, Meng, Xiang-He;Wu, Dan-Ni;Zhang, Yu-Jia;Zhao, Yu-Long published 《PPTS-Catalyzed Bicyclization Reaction of 2-Isocyanobenzaldehydes with Various Amines: Synthesis of Diverse Fused Quinazolines》. 《Advanced Synthesis & Catalysis》published the findings. The article contains the following contents:

A PPTS (pyridinium p-toluenesulfonate)-catalyzed bicyclization reaction of 2-isocyanobenzaldehydes 2-NC-4-R-5-R¹C₆H₂CHO (R = H, Br, OMe; R¹ = H, Cl, F, OMe) as 1,5-dielectrophiles with various amines R²NH₂ (R² = 3-hydroxypropyl, 2-amino-4,5-difluorophenyl, 2-(1H-pyrrol-1-yl)benzen-1-yl, etc.) has been developed. The reaction not only provides a simple and efficient strategy for the assembly of structurally diverse fused quinazoline derivatives e.g., I from readily available substrates under metal-free and mild conditions in a single step with only water and hydrogen as the byproducts, but also opens the way to the application of o-formyl arylisocyanides in the synthesis of nitrogen-containing heterocycles e.g., I. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Electric Literature of C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Voskoboinik, Olexii Yu.;Stavytskyi, Viktor V.;Antypenko, Oleksii M.;Kazunin, Maksym S.;Kravtsov, Dmytro V.;Shishkina, Svetlana V.;Kovalenkoa, Sergiy I. published 《Synthesis and structure of pyrido[1,2-a]quinazoline condensed derivatives》. The research results were published in《Synthetic Communications》 in 2020.Quality Control of 2-(1H-Benzo[d]imidazol-2-yl)aniline The article conveys some information:

Present manuscript describes the synthesis and mol. structure features of novel condensed pyrido[1,2-a]quinazolines e.g., I. The above mentioned compounds e.g., I were synthesized via condensation of 2-[azolyl-(azinyl-)]anilines 2-R-4-R¹-C₆H₃NH₂ (R = 1H-1,3-benzodiazol-2-yl, 3-methyl-1H-1,2,4-triazol-5-yl, 1H-1,2,3,4-tetrazol-5-yl, 5-oxo-6-phenyl-2,5-dihydro-1,2,4-triazin-3-yl, etc.; R¹ = H, Br) with 5-oxohexanoic acid. The tandem condensation intermediates e.g., II were isolated and cyclized under various conditions. The structures of synthesized compounds e.g., I were confirmed by LC-MS and NMR-spectroscopy. The existence of the e.g., I mols. as superposition of two resonance structures was detected by the X-Ray anal. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Quality Control of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

COA of Formula: C13H11N3《I₂/TBHP promoted isocyanide insertion cyclization reaction for the synthesis of quinazolin fused benzoimidazole as a selective methanol detection probe》 was published in 2021. The authors were Ahmadi, Fereshteh;Ahmadi, Nafiseh;Balmohammadi, Yaser;Naimi-Jamal, Mohammad Reza;Bazgir, Ayoob, and the article was included in《Catalysis Communications》. The author mentioned the following in the article:

An efficient I₂/TBHP promoted isocyanide insertion cyclization reaction for the synthesis of quinazoline-fused benzoimidazoles was reported. The synthesized compounds have a unique potential to use as a selective solvatochromic fluorescence probe for methanol detection from other solvents, especially EtOH. Introducing a simple one-step method and using a more acceptable iodine mol. instead of expensive transition metal catalysts are the most important advantages of this strategy. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 COA of Formula: C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Pandey, Rampal;Mehes, Gabor;Kumar, Ashish;Singh, Roop Shikha;Kumar, Amit;Adachi, Chihaya;Pandey, Daya Shankar published 《Strong luminescence behavior of mono- and dimeric imidazoquinazolines: Swift OLED degradation under electrical current》 in 2017. The article was appeared in 《Journal of Luminescence》. They have made some progress in their research.Product Details of 5805-39-0 The article mentions the following:

Design and synthesis of novel mono- and dimeric quinazoline derivatives (+)-6-methyl-6-pyridin-2-yl-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline (1) and (+)-6-[(6-methyl-5,6-dihydrobenzo-[4,5]imidazo[1,2-c]quinazolin-6-yl)-pyridin-2-yl]-6-methyl-5,6-dihydro-benzo-[4,5]imidazo-[1,2-c]quinazoline (2) have been described. Both 1 and 2 have been characterized by elemental analyses, FT-IR, ¹H and ¹³C NMR, HRMS spectroscopic studies and their structures authenticated by X-ray single crystal analyses. Photophys. properties of these compounds have been studied by UV/VIS absorption and fluorescence spectroscopy and transient photoluminescence anal. in solution, powder, and non-doped (neat) and doped vacuum-deposited films. A broad emission spectrum spanning most of the visible range and good thermal stability indicated promising application of 1 and 2 as OLED emitters. Unfortunately, under current flow we observed rapid device degradation, presumably to be related to free -NH moiety in these compounds And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Product Details of 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Shree, Ganesan Jeya;Sivaraman, Gandhi;Siva, Ayyanar;Chellappa, Duraisamy published 《Anthracene- and pyrene-bearing imidazoles as turn-on fluorescent chemosensor for aluminum ion in living cells》 in 2019. The article was appeared in 《Dyes and Pigments》. They have made some progress in their research.Name: 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

A newly designed 2-(2-Aminophenyl)-1H-benzimidazole integrated anthracene/pyrene derivatives as efficient chemosensors were synthesized. The probes N-(anthracen-9-ylmethylene)-2-(1H-benzo[d]imidazol-2-yl)aniline (ANP) and N-(pyren-1-ylmethylene)-2-(1H-benzo[d]imidazol-2-yl)-aniline (PYP) exhibited high selectivity and sensitivity towards Al³⁺ ion over other interfering and competing cations in aqueous solution Job’s plot anal. reveals that the interaction of ANP/PYP with Al³⁺ was 1:1 binding stoichiometry. The detection limit of probes ANP and PYP for Al³⁺ ions are 1.85 × 10^-7 M and 1.08 × 10^-7 M, resp. The DFT/TD-DFT calculations have also been revealed that the ICT mechanism is responsible for the observed photophys. changes. Moreover, the probes ANP and PYP were applicable to image intracellular Al³⁺ ions in living cells via confocal fluorescence microscopy technique. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Name: 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Korrapati, Suresh Babu;Yedla, Poornachandra;Pillai, Girinath G.;Mohammad, Faruq;Ch., Venkata Ramana Reddy;Bhamidipati, Pranav;Amanchy, Ramars;Syed, Riyaz;Kamal, Ahmed published 《In-silico driven design and development of spirobenzimidazo-quinazolines as potential DNA gyrase inhibitors》. The research results were published in《Biomedicine & Pharmacotherapy》 in 2021.Quality Control of 2-(1H-Benzo[d]imidazol-2-yl)aniline The article conveys some information:

DNA gyrase and Topoisomerase IV are promising antibacterial drug targets as they regulate bacterial DNA replication and topol. In a quest for novel DNA topoisomerase inhibitors, a multidisciplinary approach was adopted that involves computational prediction of binding sites and mol. modeling followed by green synthesis and biol. evaluation of antibacterial activity of spirobenzimidazo quinazolines derivatives Using basic quantum chem. principles, we evaluated spirobenzimidazo quinazolines derivatives with their pharmacokinetic profiles. Based on the results of the aforesaid in-silico studies, we synthesized a series of titled compounds using green synthetic methodol. that were validated as potential antimicrobial agents. Quantum chemoinformatics based predicted activity for the synthesized compounds 9b, 9c, and 9j was concomitant with biol. evaluation of broadspectrum antibacterial activity. Biol. evaluation revealed that inhibition of biofilm formation was due to their potential antibacterial activity. We believe that the novel spirobenzimidazo quinazolines have the potential to be alternatives to aminocoumarins and classical quinazolines upon detailed target specific biol. studies. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Quality Control of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem