Category: 5805-39-0

Kravtsov, Dmytro published 《Oxidation of some benzyl substituted fused quinazoline derivatives》 in 2019. The article was appeared in 《Organic Communications》. They have made some progress in their research.Recommanded Product: 5805-39-0 The article mentions the following:

In this study, synthesis of some benzoyl substituted fused quinazoline derivatives e.g., I, using Fieser’s reagent, was reported. An unexpected product fused quinazolinone and BzOH were isolated from the reaction mixture Based on the exptl. data, a possible oxidation mechanism of ketone I with chromium trioxide was described. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Recommanded Product: 5805-39-0) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Category: imidazoles-derivatives《A fluorescent chemosensor for the sequential detection of copper(II) and histidine and its biological applications》 was published in 2016. The authors were Wang, Dan;Zheng, Jian-Quan;Zheng, Xiang-Jun;Fang, De-Cai;Yuan, Da-Qiang;Jin, Lin-Pei, and the article was included in《Sensors and Actuators, B: Chemical》. The author mentioned the following in the article:

A new fluorescent sensor 6-(2,3-dihydroxyphenyl)-5,6-dihydrobenzoimidazo[1,2-c] quinazoline (H₂L) and the Zn(II) complex [Zn₂L¹2]·C₂H₅OH (H₂L¹ = 3-{[2-(1H-benzoimidazol-2-yl)-phenylimino]-methyl}-benzene-1,2-diol) (1) were synthesized and characterized by single-crystal X-ray diffraction. H₂L can be used to recognize Cu²⁺ in aqueous media as an on-off fluorescent sensor, forming the Cu(II) Schiff-base complex (CuL¹). Furthermore, CuL¹ can serve as an off-on fluorescent sensor to detect histidine (His) via the ligand displacement approach. The sequential detection of Cu(II) and histidine shows on-off-on phenomenon. The crystal structure of the dinuclear Zn(II) complex indicates that the coordination of H₂L with Zn(II) promotes C-N bond breakage, resulting in the quinazoline ring-opening of H₂L to form the Zn(II) Schiff-base complex (1). The exptl. results proved that H⁺ can also assist the ring-opening of H₂L to form a Schiff base, H₂L¹. H₂L is stable in neutral and weak basic solutions This is further confirmed by the theor. calculations The cell imaging studies indicated that H₂L and CuL¹ can be used to detect the intracellular Cu²⁺ ion and His under physiol. conditions, resp. CuL¹ can also be used to determine His in urine. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Category: imidazoles-derivatives) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Name: 2-(1H-Benzo[d]imidazol-2-yl)anilineIn 2020, Jadhavar, Pradeep S.;Patel, Kshitij I.;Dhameliya, Tejas M.;Saha, Nirjhar;Vaja, Maulikkumar D.;Krishna, Vagolu Siva;Sriram, Dharmarajan;Chakraborti, Asit K. published 《Benzimidazoquinazolines as new potent anti-TB chemotypes: Design, synthesis, and biological evaluation》. 《Bioorganic Chemistry》published the findings. The article contains the following contents:

In search for new mol. entities as anti-TB agents, the benzimidazoquinazoline polyheterocyclic scaffolds I (R¹ = H, F, Cl, Br, Me, OMe; R² = H, Cl; R³ = H, Cl; R²R³ = -(CH)₄-; R⁴ = H, Me, Et, n-Pr, n-Bu) have been designed adopting the scaffold hopping strategy. Thirty-two compounds I have been synthesized through an improved tandem decarboxylative nucleophilic addition cyclocondensation reaction of o-phenylenediamines 1,2-(NH₂)₂-4- R²C₆H₂R³ with isatoic anhydrides II followed by further cyclocondensation of the intermediately formed 2-(o-aminoaryl)benzimidazoles III with trialkyl orthoformates R⁴C(OEt)₃. The resultant benzimidazoquinazolines I were evaluated in vitro for anti-TB activity against M. tuberculosis H37Rv (ATCC27294 strain). Fourteen compounds exhibiting MIC values in the range of 0.4-6.25μg/mL were subjected to cell viability test against RAW 264.7 cell lines and found to be non-toxic (<30% inhibition at 50μg/mL). The active compounds were further evaluated against INH resistant Mtb strains. The most active compound I (R¹ = Me; R² = R³ = H; R⁴ = n-Pr) [MIC (H37Rv) of 0.4μg/mL] and the compound I (R¹ = R² = R³ = H; R⁴ = n-Pr) [MIC (H37Rv) of 0.78μg/mL] were also found to be active against INH resistant Mtb strain with MIC values of 12.5 and 0.78μg/mL, resp. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Name: 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wang, Wan-Wan;Wang, Yuan;Wu, Wei-Na;Zhao, Xiao-Lei;Xu, Zhou-Qing;Xu, Zhi-Hong;Li, Xiao-Xia;Fan, Yun-Chang published 《Pyrrole-quinazoline derivative as an easily accessible turn-off optical chemosensor for Cu²⁺ and resultant Cu²⁺ complex as a turn-on sensor for pyrophosphate in almost neat aqueous solution》 in 2020. The article was appeared in 《Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy》. They have made some progress in their research.Computed Properties of C13H11N3 The article mentions the following:

A simple chemosensor, 6-(1H-pyrrol-2-yl)-5,6-dihydro-benzo[4,5]imidazo[1,2-c]quinazoline (1), was synthesized via simple nucleophilic addition reaction coupled with Schiff base condensation. The probe 1 is aggregation-induced emission-active and could be used as an on-off fluorescence sensor toward Cu²⁺ in H₂O/CH₃CN (99.5%, volume/volume) solution Furthermore, the resultant Cu²⁺ complex selectively responded to pyrophosphate (PPi) among various anions based on fluorescent on-off signal. In addition, the probe could be used for detecting Cu²⁺ and PPi in HeLa cells. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Computed Properties of C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Donthiboina, Kavitha;Anchi, Pratibha;Gurram, Sowmyasree;Sai Mani, Geeta;Lakshmi Uppu, Jaya;Godugu, Chandraiah;Shankaraiah, Nagula;Kamal, Ahmed published 《Synthesis and biological evaluation of substituted N-(2-(1H-benzo[d]imidazol-2-yl)phenyl)cinnamides as tubulin polymerization inhibitors》 in 2020. The article was appeared in 《Bioorganic Chemistry》. They have made some progress in their research.COA of Formula: C13H11N3 The article mentions the following:

A new series of N-(2-(1H-benzo[d]imidazol-2-yl)phenyl) cinnamides I [R = H, 4-CH₃, 4-F, etc.; R¹ = H, 4-NO₂, 4-Br, etc.] was prepared and evaluated for their in-vitro cytotoxic activity using various cancer cell lines viz.A549 (human non-small cell lung cancer), MDA-MB-231 (human triple neg. breast cancer), B16-F10 (mouse melanoma), BT-474 (human breast cancer), and 4 T1 (mouse triple neg. breast cancer). In the series of tested compounds, I [R = 4-CH₃ ; R¹ = 4-OC₂H₅] showed potent cytotoxic activity against non-small cell lung cancer cell line with IC₅₀ value of 0.29 ± 0.02μM. The cytotoxicity of most potent compound I [R = 4-CH₃ ; R¹ = 4-OC₂H₅] was also tested on NRK-52E (normal rat kidney epithelial cell line) and showed less cytotoxicity compared to cancer cells. Tubulin polymerization assay indicated that the I [R = 4-CH₃ ; R¹ = 4-OC₂H₅] was able to impede the cell division by inhibiting tubulin polymerization Moreover, mol. docking study also suggested the binding of I [R = 4-CH₃ ; R¹ = 4-OC₂H₅] at the colchicine-binding site of the tubulin protein. Cell cycle anal. revealed that the I [R = 4-CH₃ ; R¹ = 4-OC₂H₅] arrests G2/M phase. In addition, I [R = 4-CH₃ ; R¹ = 4-OC₂H₅] induced apoptosis in A549 cell lines was evaluated by various staining studies like acridine orange, DAPI, anal. of mitochondrial membrane potential, annexin V-FITC, and DCFDA assays. The experimental procedure involved many compounds, such as 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 COA of Formula: C13H11N3) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Peng, Hongliang;Huang, Pengru;Yi, Pinggui;Xu, Fen;Sun, Lixian published 《Theoretical studies of π-electron delocalization and localization on intramolecular proton transfer in the ground state》 in 2018. The article was appeared in 《Journal of Molecular Structure》. They have made some progress in their research.Name: 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

Proton transfer processes of 15 benzimidazole compounds are studied by d. functional theory methods, and natural orbital energy index (NOEI) is introduced. Here, NOEI and nucleus independent chem. shift (NICS) are applied to estimate the π-electron localization and delocalization, resp. Proton transfer potential energy surfaces are calculated to explore these processes, and the results show that the changes of the π-electron delocalization of the Ph (pyridyl) is the main factors for the stability of keto form. There is high correlation between the π-electron delocalization and the proton transfer barrier. When the π-electron localization is considered, the regression increases the correlation coefficient, increasing from 0.9663 to 0.9864. NOEI index is sensitive to π-electron localization; it is a beneficial and useful complement to NICS.2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) were involved in the experimental procedure.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Name: 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Lohar, Somenath;Maji, Abhishek;Pal, Siddhartha;Mukhopadhyay, Subhra Kanti;Nag, Dipta;Demitri, Nicola;Chattopadhyay, Pabitra published 《Naphthalimide-Based Turn-On Fluorosensor for Aqueous Sulfide Ions for Staining in Living Cells》. The research results were published in《ChemistrySelect》 in 2017.Application In Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)aniline The article conveys some information:

A newly synthesized and characterized naphthalimide derivative (L¹) acts as a highly sensitive chemosensor for aqueous sulfide ions in water/DMSO (3:1, volume/volume) medium as L¹ offers distinctive reactive properties toward aqueous sulfide ions to be converted to L^1A of potential turn-on fluorescent properties over other competitive anions. Gradual addition of aqueous sulfide ions led to the formation of in situ L^1A compound which showed a single point fluorescence enhancement based on intramol. charge transfer (ICT). To establish this new interesting pathway in favor of ICT for sensing sulfide ions, the detailed spectroscopic studies of other three similar type new 1,8-naphthalimide based organic probes (L², L³ and L⁴) duly structurally characterized including theor. (DFT) studies have been carried out systematically. The probe (L¹) detects aqueous sulfide ions as low as 2.4μM in at biol. pH within a very short responsive time (15-20 s) and this non-cytotoxic the probe, L¹ is also useful in acquiring the fluorescent image of the distribution of sulfide ions in living cells using fluorescence microscope. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Application In Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wang, Yi-Ping;Ou, Xue-Rong;Wang, Yue;Liu, Jian-Quan;Wang, Xiang-Shan published 《A Consecutive Condensation, Cyclization, and Dehydration for the Synthesis of Benzimidazopyrroloquinazolines Catalyzed by TsOH》 in 2018. The article was appeared in 《Journal of Heterocyclic Chemistry》. They have made some progress in their research.Recommanded Product: 2-(1H-Benzo[d]imidazol-2-yl)aniline The article mentions the following:

A consecutive condensation, cyclization, and dehydration of 2-(1H-benzo[d]imidazol-2-yl)anilines and ketonic acid in toluene catalyzed by TsOH gave a series of benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolin-3(2H)-one derivatives, e.g., I, in good to high yields. The structure of I was further confirmed unambiguously by X-ray diffraction anal. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Recommanded Product: 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Name: 2-(1H-Benzo[d]imidazol-2-yl)aniline《Spectroscopic evaluation of a novel multi-element sensitive fluorescent probe derived from 2-(2′-phenylbenzamide)benzimidazole: Selective discrimination of Al^3 + and Cd^2 + from their congeners》 was published in 2016. The authors were Dhaka, Gargi;Kaur, Navneet;Singh, Jasvinder, and the article was included in《Inorganic Chemistry Communications》. The author mentioned the following in the article:

A novel fluorescent chemosensor 2-(2′-phenylbenzamide)benzimidazole (2) exhibiting excited-state intramol. proton transfer (ESIPT) process was synthesized by condensation approach, among which 2 could be used as a multielement sensitive fluorescent probe for both Al^3 + and Cd^2 +. The emission wavelength of 2 underwent blue shift of 78 nm upon binding with these ions. The cation-induced inhibition of ESIPT phenomenon was responsible for these fluorescence changes. Also, the absorption spectra of 2 showed changes with F^– and AcO^– ions also. TD-DFT studies well displayed the blue shift in the emission wavelength of 2 upon binding with Al^3 + ions. To complete the study, the researchers used 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) .

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Name: 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application In Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)aniline《Molecular design of amino-type hydrogen-bonding molecules for excited-state intramolecular proton transfer (ESIPT)-based fluorescent probe using the TD-DFT approach》 was published in 2021. The authors were Kanlayakan, Narissa;Kungwan, Nawee, and the article was included in《New Journal of Chemistry》. The author mentioned the following in the article:

A mol. screening has been carried out for fluorescent probes harnessing excited-stated intramol. proton transfer (ESIPT) of NH-type mols. having aminophenyl or tosylaminophenyl as a proton donor and benzimidazole, benzoxazole, benzothiazole, or imidazo[1,2-a]pyridine as a proton acceptor with different substituents using time-dependent d. functional theory. Among the designed ESIPT mols., 2-(2′-tosylaminophenyl)benzimidazole, 2-(2′-tosylaminophenyl)benzothiazole, and 2-(2′-tosylaminophenyl)imidazo[1,2-a]pyridine with dimethylamino in the tosylaminophenyl and/or cyano in the benzimidazole, benzothiazole, and imidazo[1,2-a]pyridine, resp., were revealed to be the best five candidates because they passed the screening requirements, including photophys., kinetics, and thermodn. parameters. Here, these five candidates required less photo-absorption around 380 nm and emitted the tautomer peaks in the near IR (NIR) region, leading to large Stokes shifts (~200 nm) with no self-reabsorption, which are important characteristics for fluorescent probes. The NIR emission is caused by the intramol. charge-transfer character of the strong electron-donating dimethylamino in the tosylaminophenyl moiety and heteroatoms in the benzimidazole/benzothiazole/imidazo[1,2-a]pyridine moiety as evidenced by the electron-d. differences and frontier MOs. In addition, they exhibit high photo-acidity and photo-basicity (low PT barrier with highly exothermic) to warrantee the ESIPT. Therefore, the obtained screening information in this work could be beneficial for designing new ESIPT fluorescent-based probes. And 2-(1H-Benzo[d]imidazol-2-yl)aniline (cas: 5805-39-0) was used in the research process.

2-(1H-Benzo[d]imidazol-2-yl)aniline(cas:5805-39-0 Application In Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)aniline) is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem