In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57531-38-1, name is 5-Chloro-4-nitro-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C3H2ClN3O2
To a stirred solution of Imidazole compound in DCM (10.0 vol); DMAP and TEA were added at room temperature under nitrogen atmosphere and was kept for stirring for about 30 minutes, then compound-3 was dissolved in DCM (5.0 vol) and was added slowly to it and stirred for another 2.0 hrs. On completion of the reaction, the reaction mass was diluted with water. The layers were separated and aqueous layer was extracted twice with DCM (5.0 vol). The organic layer was washed with water and brine solution and dried over anhydrous Na2S04 under reduced pressure to get yield Compound-4 (Yield 75%).
The synthetic route of 57531-38-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KANDULA, Mahesh; WO2014/68506; (2014); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem