Category: 57473-33-3

Revankar, Ganapathi R.; Matthews, Thomas R.; Robins, Roland K. published an article in 1975, the title of the article was Synthesis and antimicrobial activity of certain imidazo[1,2-a]pyrimidines.Computed Properties of 57473-33-3 And the article contains the following content:

A series of 5-substituted and 5,7-disubstituted imidazo[1,2-a]pyrimidines (I) were prepared and the in vitro antimicrobial activity of these compounds against a variety of microorganisms tested. 5-N-octylaminoimidazo[1,2-a]pyrimidine [57473-44-6] exhibited significant activity against all the microorganisms tested. The experimental process involved the reaction of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one(cas: 57473-33-3).Computed Properties of 57473-33-3

The Article related to bactericide imidazopyrimidine derivative, bactericide methylsulfinyl nitrofuran analog, Pharmacodynamics: Structure-Activity and other aspects.Computed Properties of 57473-33-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Revankar, Ganapathi R.; Robins, Roland K. published an article in 1975, the title of the article was Synthesis and biological activity of some nucleosides resembling guanosine: imidazo[1,2-a]pyrimidine nucleosides.Quality Control of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one And the article contains the following content:

Refluxing di-Et malonate in NaOEt with 2-aminoimidazole hemisulfate gave 49.6% 5,7-dihydroxyimidazo[1,2-a]pyrimidine, which was chlorinated with POCl3 and treated with 5% aqueous NaOH to give I. Refluxing I with NH(SiMe3)2 and (NH4)2SO4 followed by addition of tetra-O-acetyl-β-D-ribofuranose and deacetylation gave II (R = Cl) (III). Amination of III with NH3 in MeOH at 100° gave 46% II (R = NH2) which showed no in vitro antiviral activity with the RNA and DNA virus tested. The experimental process involved the reaction of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one(cas: 57473-33-3).Quality Control of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one

The Article related to imidazopyrimidine nucleoside, ribofuranosylimidazopyrimidine virucide, Carbohydrates: Nucleosides, Nucleotides and other aspects.Quality Control of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 15, 2012, Lin, Hong; Erhard, Karl; Hardwicke, Mary Ann; Luengo, Juan I.; Mack, James F.; McSurdy-Freed, Jeanelle; Plant, Ramona; Raha, Kaushik; Rominger, Cynthia M.; Sanchez, Robert M.; Schaber, Michael D.; Schulz, Mark J.; Spengler, Michael D.; Tedesco, Rosanna; Xie, Ren; Zeng, Jin J.; Rivero, Ralph A. published an article.Quality Control of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one The title of the article was Synthesis and structure-activity relationships of imidazo[1,2-a]pyrimidin-5(1H)-ones as a novel series of beta isoform selective phosphatidylinositol 3-kinase inhibitors. And the article contained the following:

A series of PI3K-beta selective inhibitors, imidazo[1,2-a]-pyrimidin-5(1H)-ones, has been rationally designed based on the docking model of the more potent R enantiomer of TGX-221, identified by a chiral separation, in a PI3K-beta homol. model. Synthesis and SAR of this novel chemotype are described. Several compounds in the series demonstrated potent growth inhibition in a PTEN-deficient breast cancer cell line MDA-MB-468 under anchorage independent conditions. The experimental process involved the reaction of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one(cas: 57473-33-3).Quality Control of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one

The Article related to phosphatidylinositol kinase isoform inhibitor imidazopyrimidinone preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Quality Control of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On November 30, 1993, Bhattacharya, Birendra K.; Rao, T. Sudhakar; Lewis, Arthur F.; Revankar, Ganapathi R.; Sanghvi, Yogesh S.; Robins, Roland K. published an article.Safety of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one The title of the article was Synthesis of certain N- and C-alkyl purine analogs. And the article contained the following:

A number of N- and C-alkyl derivatives of selected guanine analogs have been synthesized as potential antiviral agents. N-Pentyl, N-hexyl and 6-hydroxyhexyl derivatives in the imidazo[1,2-a]-s-triazine, I [R = (CH2)4Me, (CH2)5Me, (CH2)5CH2OH, X = NH2] , imidazo[1,2-a]pyrimidine, I (X = Cl, NH2), and thiazolo[4,5-d]pyrimidine, II, ring system have been prepared by the direct alkylation of the sodium salt of the appropriate aglycon with the resp. alkylbromides. Dehydrative coupling of 3-amino-6-hydrazino-1,2,4-triazin-5(4H)-one with either hexanoic acid or heptanoic acid, and further ring closure of the reaction products provided the n-pentyl and n-hexyl derivatives of 6-amino-1,2,4-triazolo[3,4-f][1,2,4]triazin-8(7H)-one III [R1 = (CH2)4Me, (CH2)5Me, X = NH, Y = N], resp. A similar condensation of 3-amino-6-aminomethyl-1,2,4-triazin-5(4H)-one with heptanoic acid, followed by ring annulation, readily gave 2-amino-7-n-hexylimidazo[5,1-f][1,2,4]triazin-4(3H)-one III [R1 = (CH2)5Me, X = CH2, Y = CH] (IV). Bromination of IV with N-bromosuccinimide afforded the corresponding 5-bromo derivative Alkylation of the in situ generated sodium salt of 4-methoxycarbonylmethyl-5-methoxycarbonyl-2-oxo-1H,3H-imidazole with 1-bromohexane gave the N-1 alkylated product. Manipulation of the functional groups in the latter compound and further hydrazine mediated ring annulation furnished 5,6-diamino-1-n-hexyl-3-methylimidazo[4,5-c]pyridine-2,4-dione. The experimental process involved the reaction of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one(cas: 57473-33-3).Safety of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one

The Article related to purine alkyl analog, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Safety of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On April 30, 1991, Seela, F.; Rosemeyer, H.; Gumbiowski, R.; Mersmann, K.; Muth, H. P.; Roeling, A. published an article.Formula: C6H4ClN3O The title of the article was Base-modified purine 2′,3′-dideoxyribonucleosides: synthesis via deoxygenation or direct nucleobase anion glycosylation. And the article contained the following:

A symposium report. 5-Aza-7-deazapurine, 5-aza-1,7-dideazapurine, and 8-azapurine 2′,3′-dideoxy-D-ribonucleosides were synthesized and inhibitory activity against HIV reverse transcriptase and DNA-polymerases was evaluated. The experimental process involved the reaction of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one(cas: 57473-33-3).Formula: C6H4ClN3O

The Article related to purine dideoxyribonucleoside base modified symposium, deoxygenation nucleoside symposium, nucleobase anion glycosylation symposium, hiv reverse transcriptase inhibitor symposium, dna polymerase inhibitor symposium, aids inhibitor purine dideoxyribonucleoside symposium, azadeazapurine dideoxyribonucleoside symposium and other aspects.Formula: C6H4ClN3O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On July 31, 1992, Seela, Frank; Gumbiowski, Rainer published an article.Category: imidazoles-derivatives The title of the article was Imidazo[1,2-a]pyrimidine 2′-deoxyribo- and 2′,3′-dideoxyribonucleosides: glycosylation of the nucleobase anion. And the article contained the following:

The synthesis of the imidazopyrimidine deoxyribonucleosides I (R = NH2, H, R1 = H, R2 = H, OH) via stereoselective glycosidation of the nucleobase anion of II, is described. The inhibitory activity of the dideoxynucleoside 5′-triphosphates I (R = H, NH2, R1 = P3O9H4, R2 = H) against HIV reverse transcriptase was tested. The experimental process involved the reaction of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one(cas: 57473-33-3).Category: imidazoles-derivatives

The Article related to imidazopyrimidine deoxyribonucleoside preparation phosphorylation, nucleotide dideoxy imidazopyrimidine triphosphate enzyme inhibition, nucleoside deoxy imidazopyrimidine preparation phosphorylation, stereoselective glycosidation chloroimidazopyrimidinone and other aspects.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem