Category: 570-22-9

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 570-22-9 name is 1H-Imidazole-4,5-dicarboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 570-22-9

Example 29 Diethyl imidazole-4,5-dicarboxylate (46) Imidazole-4,5-dicarboxylic acid (7.55 g, 50.0 mmol) is dissolved in absolute ethyl alcohol (120 mL). The solution was cooled in an ice bath to 0 C. and bubbled dry HCl gas for 1 h. Later, the reaction mixture was refluxed at 80 C. for 7 h during which time all the starting material was consumed. The solvent was removed and the residue that obtained was dissolved in dichloromethane (200 mL) and the organic layer was neutralized with triethylamine. The organic layer was washed with cold water (100 mL) and brine (50 mL), dried over anhydrous sodium sulfate and concentrated in vacuo to give 5.50 g (52%) of white solid: mp 175-177 C.; 1 H NMR (CDCl3) delta 1.40 (t, 3H), 4.41 (m, 2H), 7.84 (1H, C2 H) and 11.55 (br s, 1H, NH).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Imidazole-4,5-dicarboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; ICN Pharmaceuticals, Inc.; US6130326; (2000); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

570-22-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of imidazole-4,5-dicarboxylic acid (400 mg, 2.56 mmol) in 5 mL of toluene was added 1.12 mL of thionyl chloride (15.38 mmol) and 0.1 mL of DMF at rt. The reaction mixture was stirred at 90 C for 16 h. Then 5 mL of DCM was added to the suspension and the solvent was removed by evaporation. This process was repeated twice. The resulting acid chloride was dissolved in 10 mL of DCM and cooled to 0 C. Phenol (2.82 mmol) in 5 mL of DCM was added and the resulting solution was stirred at 0 C for 1 h. Then the solid product was collected by vacuum filtration, washed with 10 mL of DCM twice, and dried under vacuum to yield 0.632 g of crude product 17 (83.6 % over two steps) as a tan solid. 1H NMR (300Hz, DMSO) delta 9.12 (s, 2H), 7.52-7.56 (m, 4H), 7.34-7.40 (m, 6H); ESI-MS: 429 [M+1]+

The synthetic route of 1H-Imidazole-4,5-dicarboxylic acid has been constantly updated, and we look forward to future research findings.

Reference:
Article; Serrao, Erik; Xu, Zhong-Liang; Debnath, Bikash; Christ, Frauke; Debyser, Zeger; Long, Ya-Qiu; Neamati, Nouri; Bioorganic and Medicinal Chemistry; vol. 21; 19; (2013); p. 5963 – 5972;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

570-22-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of imidazole-4,5-dicarboxylic acid (400 mg, 2.56 mmol) in 5 mL of toluene was added 1.12 mL of thionyl chloride (15.38 mmol) and 0.1 mL of DMF at rt. The reaction mixture was stirred at 90 C for 16 h. Then 5 mL of DCM was added to the suspension and the solvent was removed by evaporation. This process was repeated twice. The resulting acid chloride was dissolved in 10 mL of DCM and cooled to 0 C. Phenol (2.82 mmol) in 5 mL of DCM was added and the resulting solution was stirred at 0 C for 1 h. Then the solid product was collected by vacuum filtration, washed with 10 mL of DCM twice, and dried under vacuum to yield 0.632 g of crude product 17 (83.6 % over two steps) as a tan solid. 1H NMR (300Hz, DMSO) delta 9.12 (s, 2H), 7.52-7.56 (m, 4H), 7.34-7.40 (m, 6H); ESI-MS: 429 [M+1]+

The synthetic route of 1H-Imidazole-4,5-dicarboxylic acid has been constantly updated, and we look forward to future research findings.

Reference:
Article; Serrao, Erik; Xu, Zhong-Liang; Debnath, Bikash; Christ, Frauke; Debyser, Zeger; Long, Ya-Qiu; Neamati, Nouri; Bioorganic and Medicinal Chemistry; vol. 21; 19; (2013); p. 5963 – 5972;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

570-22-9,Some common heterocyclic compound, 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid, molecular formula is C5H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The synthesis method is as follows: In a 100 ml single-mouth flask, add 2.85g (10mmol) dehydroabietylamine, 1.87g (12mmol) imidazol-4,5-dicarboxylic acid (molar ratio of 1:1.2) and 50 ml of toluene. 110 C reflux condenser reaction 8h. After the reaction heat filter, steaming and obtaining white solid, quality is 2.0329g, yield of 46.1%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Imidazole-4,5-dicarboxylic acid, its application will become more common.

Reference:
Patent; Nanjing Forestry University; Xu, Li; Zhao, Fengyi; Xu, Yuanyuan; Yang, Shilong; Sun, Li; Wang, Luna; Wang, Weifan; (9 pag.)CN105037191; (2017); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

570-22-9, The chemical industry reduces the impact on the environment during synthesis 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid, I believe this compound will play a more active role in future production and life.

A mixture of CaCl2 (0.012 g, 0.1 mmol), H3imdc (0.039 g,0.25 mmol), Zn(Ac)2?2H2O (0.022 g, 0.1 mmol) and a buffer solution of HAc-NaAc (pH = 5.7, 2 mL) was put into 25 mL Teflon-lined stainless steel autoclave and heated at 180 C for 3 days, then cooled to room temperature. Dark yellow block crystals were obtained by filtration to give a yield of 32.7% (0.010 g). Elemental Anal. Calc. for C12H8Ca2N4O12Zn2: C, 23.58; H, 1.32; N, 9.17. Found: C, 23.22; H, 1.37; N, 8.95%. IR (KBr, cm-1): 3448 s, 1600 s, 1482 vs 1400 s, 1252 m, 1105 m, 804 m, 664 m.

The chemical industry reduces the impact on the environment during synthesis 1H-Imidazole-4,5-dicarboxylic acid. I believe this compound will play a more active role in future production and life.

Reference:
Article; Ablet, Ayjamal; Li, Shu-Mu; Cao, Wei; Zheng, Xiang-Jun; Jin, Lin-Pei; Polyhedron; vol. 83; (2014); p. 122 – 129;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem