Category: 570-22-9

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 570-22-9 as follows. name: 1H-Imidazole-4,5-dicarboxylic acid

General procedure: Ethane-1,2-diamine (4a; 60mg; 1mmol) and iminodiacetic acid (5; 266mg; 2mmol) were mixed thoroughly, grinded and subjected to focused microwave irradiation at 135 C for 4 minutes. TLC of reaction mixture over silica gel G using ethyl acetate: MeOH (7:3) as mobile phase showed that the reaction is complete. Crude product, so obtained was purified by crystallization from methanol: water (9.5:0.5) to give pure product 9a. Yield: 83%.

According to the analysis of related databases, 570-22-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kumar, Anuj; Banerjee, Somesh; Roy, Partha; Sondhi; Sharma, Anuj; Bioorganic and Medicinal Chemistry Letters; vol. 27; 3; (2017); p. 501 – 504;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 570-22-9,Some common heterocyclic compound, 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid, molecular formula is C5H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a dry round-bottom flask was added 1.0 g of imidazole-4,5-dicarboxylic acid (10, 1 mmol) and 10 mL of toluene. To this stirred suspension were added 3.0 mL of thionyl chloride (6.5 mmol) and 0.250 mL of DMF (catalytic). The resulting mixture was refluxed for 16 h. After the mixture was cooled in ice bath, the solid product was collected by vacuum filtration, washed with two 20 mL portions of toluene, and dried under vacuum to yield 0.95 g of crude 11 (Yield: 95%) as a yellow solid. This product was used further without characterization.

The synthetic route of 570-22-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Saudi, Milind; Zmurko, Joanna; Kaptein, Suzanne; Rozenski, Jef; Neyts, Johan; Van Aerschot, Arthur; European Journal of Medicinal Chemistry; vol. 87; (2014); p. 529 – 539;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

These common heterocyclic compound, 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C5H4N2O4

The complex was synthesized by hydrothermal method. A mixture of Zn(NO3)2.6H2O (0.47 g; 1.6 mmol), H3idc (0.25 g, 1.6 mmol) and water (30 mL) was sealed in a 45 mL Parr brand teflon-linedacid digestion bomb and heated at 180 C for 5 days, and then cooled to room temperature at a rate of 5 C/h. Pale yellow crystals of 1 were obtained (yield: 0.195 g, 73% based on Zn(NO3)26H2O). Anal. Calc. for C10H2N4O8Zn3: C, 23.91; H, 0.40; N, 11.15. Found:C, 23.90; H, 0.52; N, 10.90%. IR data (KBr, cm1): 3531m, 3359m, 3120m, 1589s, 1544s, 1474s, 1477s, 1384s, 1296m, 1253s, 1205m, 1107s, 1020w, 871m, 835m, 792m, 661m, 540w.

The synthetic route of 1H-Imidazole-4,5-dicarboxylic acid has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 570-22-9, Safety of 1H-Imidazole-4,5-dicarboxylic acid

H3IMDC ligand (0.1500 g, 0.961 mmol) was dissolved in a baker with 30mL of deionizated water and 3.45 mL of NaOH dissolution (0.276 mol L-1) and left stirring in a round bottom flask. Then, when all the ligand was dissolved, 0.4548 g of Co(hfacac)2 (0.952 mmol) previously disolved in 10 mL of absolute ethanol was added. A pale orange suspension was formed which was left stirring for 3 hours and filtered under vacuum using a porous glass filter. The solid was washed first with 10 mL cool water and 15 mL of cool ethanol and then dried overnight at 70C. Yield: 182 mg (0.449 mmol, 47%)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Imidazole-4,5-dicarboxylic acid, and friends who are interested can also refer to it.

Reference:
Article; Arrue, Ramon; Toledo, Dominique; Pena, Octavio; Pivan, Jean-Yves; Reis, Mario; Moreno, Yanko; Journal of the Chilean Chemical Society; vol. 63; 2; (2018); p. 4006 – 4011;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 570-22-9,Some common heterocyclic compound, 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid, molecular formula is C5H4N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 29 Diethyl imidazole-4,5-dicarboxylate (46) Imidazole-4,5-dicarboxylic acid (7.55 g, 50.0 mmol) is dissolved in absolute ethyl alcohol (120 mL). The solution was cooled in an ice bath to 0 C. and bubbled dry HCl gas for 1 h. Later, the reaction mixture was refluxed at 80 C. for 7 h during which time all the starting material was consumed. The solvent was removed and the residue that obtained was dissolved in dichloromethane (200 mL) and the organic layer was neutralized with triethylamine. The organic layer was washed with cold water (100 mL) and brine (50 mL), dried over anhydrous sodium sulfate and concentrated in vacuo to give 5.50 g (52%) of white solid: mp 175-177 C.; 1 H NMR (CDCl3) delta 1.40 (t, 3H), 4.41 (m, 2H), 7.84 (1H, C2 H) and 11.55 (br s, 1H, NH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Imidazole-4,5-dicarboxylic acid, its application will become more common.

Reference:
Patent; ICN Pharmaceuticals, Inc.; US6130326; (2000); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 1H-Imidazole-4,5-dicarboxylic acid

Into a 100mL round bottom flask, successively added the 1-hydimidazole-4, 5-dicarboxylic acid (600 mg, 1eq, 3.84mmol), thionyl chloride (1.81mL, 6.5eq, 24.8mmol), ultra-dry dimethylformamide (DMF) (0.15mL, 0.5eq, 1.92mmol) and 5mL of toluene, refluxed at 90 C for 16 h. After the reaction, cooling, by using too much toluene in the reaction solution with straw, dissolved in thionyl chloride and DMF aspiration, toluene washed twice and then obtained crude product (compound 1), without further purification directly use for the next step.

The synthetic route of 570-22-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Long Yaqiu; Xu Zhongliang; Wang Heyao; Cai Mengxin; (31 pag.)CN106892871; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 570-22-9, name: 1H-Imidazole-4,5-dicarboxylic acid

Thionyl chloride (94 ml; 1.29 mol) was added to a suspension of 1H-imidazole4;5- dicarboxylic acid (25 g; 157 mmol) in toluene (334 ml) and N;N-dimethylformamide (12.1 ml) and the mixture was stirred for 24 h at 80C. The mixture was concentrated under reduced pressure; 100 ml toluene were added and the mixture was concentrated under reduced pressure to give 35.5 g of the title compound as crude material; which was usedat the same day without further purification for subsequent steps.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Imidazole-4,5-dicarboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; EIS, Knut; ACKERSTAFF, Jens; WAGNER, Sarah; BUCHGRABER, Philipp; SUeLZLE, Detlev; BENDER, Eckhard; LI, Volkhart Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philip; (136 pag.)WO2017/55313; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 570-22-9, These common heterocyclic compound, 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of CoCl2¡¤6H2O (0.1 mmol, 0.0237 g), imidazole-4,5-dicarboxylate (0.1 mmol,0.0156 g), 1,4-bis(1-imidazoly)benzene (0.1 mmol, 0.0210 g), NaOH (0.2 mmol, 0.0800 g), H2O(10 mL) and DMF (2 mL) was stirred for 1 h in air, then transferred to and sealed in a 25 mLTeflon-lined reactor and heated in an oven to 110 C for 72 h. After cooling to room temperature,brown block crystals of 1 were collected by ltration and washed with water and DMFseveral times.

Statistics shows that 1H-Imidazole-4,5-dicarboxylic acid is playing an increasingly important role. we look forward to future research findings about 570-22-9.

Reference:
Article; Wang, Ke-Hua; Journal of Coordination Chemistry; vol. 70; 24; (2017); p. 3982 – 3995;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 570-22-9, These common heterocyclic compound, 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

REFERENCE EXAMPLE 13 4,5-Bis(ethoxycarbonyl)imidazole A mixture of 4.0 g (25.6 mmols) of imidazole-4,5-dicarboxylic acid, 600 ml of ethanol and 16 ml of conc. sulfuric acid was heated under reflux for 7 hours. After cooling to 0 C., the mixture was neutralized with a 2 normal aqueous sodium hydroxide solution. The solvent was evaporated under reduced pressure, and then water was added to the residue followed by extraction of the solution with chloroform. The chloroform layer was washed with an aqueous saturated sodium bicarbonate solution and then with an aqueous saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was dried to afford 2.5 g (yield: 46%) of the title compound. NMR (CDCl3) delta (ppm): 7.83(1H, s), 7.26(1H, s), 4.41 (4H, q, J=7.2 Hz), 1.38(6H, t, J=7.2 Hz)

The synthetic route of 570-22-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kyowa Hakko Kogyo Co., Ltd.; US5053408; (1991); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid, A new synthetic method of this compound is introduced below., 570-22-9

In a dried flask, to 1H-imidazole-4,5-dicarboxylic acid (25 g, 157 mmol) in toluene (334 ml), DMF (12.1 ml) and thionyl chloride (94 ml, 1.29 mol) were added. The mixture was stirred for24 h at 80G. The mixture was concentrated under reduced pressure. Toluene (100 ml) was added and the mixture was concentrated under reduced pressure to give 35.5 g of the title compound as crude material which was used at the same day without further purification for subsequent steps.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; WAGNER, Sarah; SUeLZLE, Detlev; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philip; (232 pag.)WO2018/78009; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem