Category: 5496-35-5

Crystal structures and solution spectroscopy of lophine derivatives was written by Fridman, Natalya;Kaftory, Menahem;Eichen, Yoav;Speiser, Shammai. And the article was included in Journal of Molecular Structure in 2009.Category: imidazoles-derivatives This article mentions the following:

Lophine (2,4,5-triphenylimidazole) derivatives were synthesized and their physicochem. properties were determined Spectroscopic and fluorescence behavior of lophine derivatives in methanol at different pH and various solvents were presented. The observed spectroscopic features in the solution are determined by specific interactions of the NH hydrogen. These kinds of interactions are manifested both in the solid state and in solution The crystal and mol. structures of lophine derivatives with different solvents of crystallization are presented and discussed. In all solvates the solvent mols. link host mols. through hydrogen bonds. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Category: imidazoles-derivatives).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid was written by Kortagere, Sandhya;Madani, Navid;Mankowski, Marie K.;Schon, Arne;Zentner, Isaac;Swaminathan, Gokul;Princiotto, Amy;Anthony, Kevin;Oza, Apara;Sierra, Luz-Jeannette;Passic, Shendra R.;Wang, Xiaozhao;Jones, David M.;Stavale, Eric;Krebs, Fred C.;Martin-Garcia, Julio;Freire, Ernesto;Ptak, Roger G.;Sodroski, Joseph;Cocklin, Simon;Smith, Amos B. III. And the article was included in Journal of Virology in 2012.HPLC of Formula: 5496-35-5 This article mentions the following:

The HIV-1 capsid (CA) protein plays essential roles in both early and late stages of virl replication and has emerged as a novel drug target. We report hybrid structure-based virtual screening to identify small mols. with the potential to interact with the N-terminal domain (NTD) of HIV-1 CA and disrupt early, preintegration steps of the HIV-1 replication cycle. The small mol. 4,4′-[dibenzo[b,d]furan-2,8-diylbis(5-phenyl-1H-imidazole-4,2-diyl)]dibenzoic acid (CK026), which had anti-HIV-1 activity in single- and multiple-round infections but failed to inhibit viral replication in peripheral blood mononuclear cells (PBMCs), was identified. Three analogs of CK026 with reduced size and better drug-like properties were synthesized and assessed. Compound I-XW-053 (4-(4,5-diphenyl-1H-imidazol-2-yl)benzoic acid) retained all of the antiviral activity of the parental compound and inhibited the replication of a diverse panel of primary HIV-1 isolates in PBMCs, while displaying no appreciable cytotoxicity. This antiviral activity was specific to HIV-1, as I-XW-053 displayed no effect on the replication of SIV or against a panel of nonretroviruses. Direct interaction of I-XW-053 was quantified with wild-type and mutant CA protein using surface plasmon resonance and isothermal titration calorimetry. Mutation of Ile37 and Arg173, which are required for interaction with compound I-XW-053, crippled the virus at an early, preintegration step. Using quant. PCR, we demonstrated that treatment with I-XW-053 inhibited HIV-1 reverse transcription in multiple cell types, indirectly pointing to dysfunction in the uncoating process. In summary, we have identified a CA-specific compound that targets and inhibits a novel region in the NTD-NTD interface, affects uncoating, and possesses broad-spectrum anti-HIV-1 activity. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5HPLC of Formula: 5496-35-5).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.HPLC of Formula: 5496-35-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

An efficient ICT based fluorescent turn-on dyad for selective detection of fluoride and carbon dioxide was written by Ali, Rashid;Razi, Syed S.;Gupta, Ramesh C.;Dwivedi, Sushil K.;Misra, Arvind. And the article was included in New Journal of Chemistry in 2016.Name: 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid This article mentions the following:

A new intramol. charge transfer (ICT) based fluorescent turn-on ratiometric probe 2 (D-蟺-A type) has been designed and synthesized by bridging imidazole (donor, D) and benzothiazole (acceptor, A) moieties through a Ph ring. The photophys. behavior of probe 2 in solvents of different polarities and at different pH values has been investigated. Upon interaction with different types of anions probe 2 showed selective high affinity for fluoride anions (F^–) in aqueous DMSO (20%) solution The ratiometric fluorescence turn-on behavior displayed by 2 with F^– is attributed to changes in the ICT process. Job’s plot anal. revealed a 1 : 1 binding stoichiometry for 2 + F^– interactions with a high binding constant and detection sensitivity (30 ppb). Moreover, a solution of 2 + F^– enabled the detection of CO₂ (鈭?00 ppb; 2.29 渭M) through enhanced emission. The mode of interaction has been confirmed by ¹H NMR titration studies which suggested the deprotonation of the -NH fragment of an imidazolyl unit in the presence of F^–. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Name: 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Name: 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chemiluminescent intensities from substituted lophines was written by Philbrook, G. E.;Maxwell, M. A.. And the article was included in Tetrahedron Letters in 1964.Formula: C22H16N2O2 This article mentions the following:

Chemiluminescent intensities of 14 lophine derivatives, substituted in the 3 and (or) 4 position(s) of the 2-phenyl group, were determined in 7:3 Me₂SO-H₂O solution, N in NaOH. O was passed through the solution continuously. The intensity of emission passed through a maximum (I_maximum) after 1-2 min. and then declined. A Hammett plot of I_maximum/I₀ against 蟽 values was reported, where I₀ is the intensity maximum for lophine (I). The observed slope, -1.96 卤 0.06, compares with a value of -1.16 卤 0.06 obtained when similar plots were constructed with 蟽⁺ values (Brown and Okamoto, CA 53, 9120f). The emission intensity was a linear function of concentration for I, and the 4-carboxy, 4-MeO, 3,4-dimethoxy, and 4-Cl derivatives over the concentration range 3 脳 10^-3 to 3 脳 10^-5 M. The chemiluminescent maximum for all the compounds, except the nitro derivative, fell at 5300 A. It appeared that the chemiluminescent processes in all cases examined yield the same mol. fragment. Probably the substituent present in the original derivative was not present in this fragment. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Formula: C22H16N2O2).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Formula: C22H16N2O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Structures and photophysics of lophine and double lophine derivatives was written by Fridman, Natalya;Kaftory, Menahem;Speiser, Shammai. And the article was included in Sensors and Actuators, B: Chemical in 2007.SDS of cas: 5496-35-5 This article mentions the following:

Novel lophine (2,4,5-triphenylimidazole) derivatives, ortho-, meta- and para-substituted in the 2-Ph ring and p-Ph, p-tolyl, and p-anisyl rings in the 4- and 5-aryl rings and double lophine derivatives were synthesized and their physico-chem. properties were determined We included arylimidazoles, derivatives substituted with electron-donating and electron attracting groups. MeO- and OH-groups release electrons and activate the ring. In contrast, COOH- and CN-groups withdraw electrons and deactivate the ring. Nitro derivatives of imidazole, phenol, 2-[4,5-bis(4-methoxyphenyl)-1H-imidazole-2-yl]-4-nitro 23 and phenol, 2-[4,5-bis(4-methyl-phenyl)-1H-imidazole-2-yl]-4-nitro 24 crystallize with guest mols. in various colors. Double imidazole derivatives of lophine, 2,2′-(2,5-thiophenediyl)bis[4,5-diphenyl-1H-imidazole] 27 and 2,2′-(1,4-phenylene)bis[4,5-diphenyl-1H-imidazole] 29 show piezochromism, photochromism and thermochromism in the solid state and form inclusion compounds in various colors. Four inclusion compounds in two different colors: yellow and green, depending on the solvent mols. were found for 27 and two different colors: light yellow and colorless were obtained for 29. The fluorescence intensity for 27 substituted with MeO-group in the 4,5-Ph rings is decreased and it is increased for 29 by changing Ph rings to MeO-substituent in the 4,5-Ph rings. Upon irradiation with UV light at room temperature, green solution of 29 turned into orange and colorless solution of 29 turned into light yellow. The photochem. properties of 27 and 29 and their derivatives were studied by irradiating basic and neutral degassed acetonitrile solutions with medium pressure xenon lamp and their photochem. quantum yields, ranging from 0.0011 to 0.0024, together with the corresponding fluorescence quantum yields, ranging from 0.52 to 0.90 and lifetimes, ranging from 1.03 to 1.42 ns were determined These compounds are sensitive to different external stimulations, such as UV irradiation, heat, increasing pressure, and changing of the environmental pH, causing spectral changes. Our results suggest potential applications of these compounds in mol. photonics and sensing. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5SDS of cas: 5496-35-5).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.SDS of cas: 5496-35-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Prop-2-en-1-yl 4-(4,5-diphenyl-1H-imidazol-2-yl)benzoate was written by Mohamed, Shaaban K.;Akkurt, Mehmet;Marzouk, Adel A.;Abdelhamid, Antar A.;Santoyo-Gonzalez, Francisco. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2013.Category: imidazoles-derivatives This article mentions the following:

Prop-2-en-1-yl 4-(4,5-diphenyl-1H-imidazol-2-yl)benzoate, C₂₅H₂₀N₂O₂, crystallized with 2 mols. in the asym. unit, in 1 of which the atoms of the terminal propenyl group are disordered over 2 sets of sites, with a refined occupancy ratio of 0.870(4):0.130(4). The central imidazole ring makes dihedral angles of 25.51(11), 40.73(11) and 27.36(11)掳 with the 3 pendant rings in 1 mol. and 22.56(10), 60.72(10) and 5.85(10)掳 in the other. In the crystal, mols. are linked by N-H路路路N and C-H路路路O H bonds, forming a 3-dimensional network. The crystal structure also features C-H路路路蟺 interactions and 蟺-蟺 stacking [centroid-centroid distances = 3.8834(18) and 3.9621(17) 脜] interactions. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5Category: imidazoles-derivatives).

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic acid (cas: 5496-35-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem