As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5468-66-6 name is 2-(4-Chlorobenzyl)benzimidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 5468-66-6
General procedure: To a 25 mL of Schlenk tube equipped with a Teflon septum were added Imidazoles/Pyrazoles (0.4 mmol, 1.0 equiv) and KF (46.4 mg, 2.0 equiv) under Ar, followed by MeCN (3 mL) with stirring. 2 (0.40 mmol, 1.0 equiv) were added subsequently. After stirring for 12 h, the reaction mixture was concentrated. The residue was purified with silica gel chromatography to provide pure product.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(4-Chlorobenzyl)benzimidazole, and friends who are interested can also refer to it.
Reference:
Article; Mao, Ting; Zhao, Liang; Huang, Yang; Lou, Yue-Guang; Yao, Qiuli; Li, Xiao-Fei; He, Chun-Yang; Tetrahedron Letters; vol. 59; 28; (2018); p. 2752 – 2754;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem