Category: 54624-57-6

Application of 54624-57-6, The chemical industry reduces the impact on the environment during synthesis 54624-57-6, name is 2-Bromobenzimidazole, I believe this compound will play a more active role in future production and life.

(1) In a 250 mL three-necked flask, nitrogen gas was introduced, and 0.02 mol of the raw material B1, 0.03 mol of the raw material E1, 0.04 mol of sodium hydride,0.004 mol of cuprous iodide and 0.01 mol of phenanthroline are dissolved in 100 ml of 1,3-dimethyl-2-imidazolidinone, and the reaction is stirred for 20-30 h.After the reaction, water was added and the mixture was extracted with dichloromethane.The mixture was washed with a mixture of petroleum ether and ethyl acetate, and the volume ratio of petroleum ether to ethyl acetate in the eluent was 1:100.Purification by column chromatography gave Intermediate X1; HPLC purity: 99.7%, yield 78.5%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromobenzimidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Wang Fang; Zhang Zhaochao; Li Chong; Zhang Xiaoqing; (57 pag.)CN109956933; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54624-57-6, name is 2-Bromobenzimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. category: imidazoles-derivatives

2-bromo-1 H-benzo[d]imidazole (177 mg, 0.9 mmol), bispinacolato diboron (250 mg, 0.99 mmol) and KOAc (265 mg, 2.7 mmol) were dissolved in dioxane (9 ml). After purging with N2, Pd(dppf)CI2 (37 mg, 0.045 mmol) was added. After stirring overnight at reflux temperature the reaction was cooled to room temperature the reaction mixture was diluted with some ethyl acetate (20 ml). The mixture was filtrated through a pad of celite and the solvent was evaporated under reduced pressure to give 2-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)-1 H- benzofdlimidazole as a black oil. The crude product was used in the next step without further purification

The synthetic route of 54624-57-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MSD OSS B.V.; HUISMAN, Ines; VAN DER STELT, Marcelis; WIEDENHOF, Wouter; BAKER-GLENN, Charles, Anthony, Graham; BLACKABY, Wesley, Peter; TRIVEDI, Naimisha; WO2013/41457; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 54624-57-6, name is 2-Bromobenzimidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 54624-57-6, category: imidazoles-derivatives

2-bromobenzoimidazole 100mmol, nitrogen eight membered (or sulfur) heterocyclic boride intermediate 220mmol were added to a 1L three-necked flask, was dissolved in 400mL of toluene, was added under nitrogen tetrakistriphenylphosphine palladium 1.5mmol, 250mmol potassium carbonate, distilled water 100mL, the reaction was stirred at reflux for 24 hours, cooled to room temperature, after the reaction liquid separation, silica gel funnel, washing, spin-dry, recrystallized, filtered, 65mmol obtain compound 8 as a white solid, yield 65percent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromobenzimidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jilin Optical and Electronic Materials Co., Ltd.; Ma, Xiaoyu; Song, Qiaohong; Zhao, He; (22 pag.)CN105315229; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 54624-57-6, These common heterocyclic compound, 54624-57-6, name is 2-Bromobenzimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 2-bromobenzimidazole (0.05 g, 0.254 mmol), 2-fluoropyridine-5-boronic acid (0.036 g, 0.254 mmol), Potassium carbonate (0.190 ml, 0.381 mmol), and PdCl2(dppf)2DCM (10.36 mg, 0.013 mmol) in DMF (1.0 mL) was heated at 150 ¡ãC for 15 rain. The crude product was purifled by prepHPLC to afford T452 (6 mg, 11.09 percent).

The synthetic route of 54624-57-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eli Lilly and Company; Cashion, D.K; chen, G.; Kasi, D; kolb, C; liu, C; sinha, A; Szardenings, A.k; wang, E; yu, C; zhang, W; Gangadharmath, Umesh B; Walsh, J.C; (204 pag.)CN102985411; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 54624-57-6, A common heterocyclic compound, 54624-57-6, name is 2-Bromobenzimidazole, molecular formula is C7H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2. 2-(lH-Benzoimidazol-2-yl)-3-cyclohexyl-lH-indole-6-carboxylic acid methyl ester (10.3)A reaction flask was charged with 100 mg (0.26 mmol) 10.2, 64 mg (0.33 mmol, 1.25 eq) 2-bromobenzimidazole and 15 mg (0.013 mmol, 0.05 eq) Pd(PPh3 )4. To this was added 4 mL dioxane and 1 mL NaHCO3 (sat., aq.). The reaction mixture was degassed and purged with Argon (2x), and then gently heated to 90 0C for 4 h. HPLC and LC-MS analysis confirmed complete consumption of 10.2. The reaction mixture was allowed to cool to room temperature and then concentrated. The desired methyl ester was precipitated by addition of cold H2O and collected by centrifuge. 10.3 was dried under vacuum and used without further purification. MS: 374.1 (M+H+).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GENELABS TECHNOLOGIES, INC.; WO2008/11521; (2008); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 54624-57-6, name is 2-Bromobenzimidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 54624-57-6, COA of Formula: C7H5BrN2

Sodium hydride (60% dispersion in mineral oil, 0.665 g, 16.63 mmol) was added to a solution of 2-bromo-1H-benzo[d]imidazole (2.73 g, 13.86 mmol) in DMF (30 mL), and the reaction stirred for 10 minutes at ambient temperature. 1-Bromo-2-methoxyethane (1.541 ml, 16.63 mmol) was added, and reaction stirred overnight at ambient temperature. The reaction was diluted with ethyl acetate and washed several times with brine. The organic layer was separated and dried over anhydrous magnesium sulfate, filtered and concentrated. The residue was purified via column chromatography on a 100 gram silica gel column eluting with 20-40% ethyl acetate-hexane. The desired fractions were combined and concentrated to afford 2-bromo-1-(2-methoxyethyl)-1H-benzo[d]imidazole (2.9 g, 82%) as an orange oil. 1H NMR (300 MHz, DMSO-d6) delta ppm 7.54-7.67 (m, 2H) 7.14-7.34 (m, 2H) 4.42 (t, J=5.28 Hz, 2H) 3.67 (t, J=5.28 Hz, 2H) 3.20 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromobenzimidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Forma Therapeutics, Inc.; Bair, Kenneth W; Barczak, Nicholas; Han, Bingsong; Lancia, JR., David R.; Liu, Cuixian; Martin, Matthew W; Ng, Pui Yee; Rudnitskaya, Aleksandra; Thomason, Jennifer R; Zablocki, Mary Margaret; Zheng, Xiaozhang; (195 pag.)US2016/264518; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 54624-57-6, name is 2-Bromobenzimidazole, This compound has unique chemical properties. The synthetic route is as follows., 54624-57-6

Step 1. l-allyl-2-bromo-lH-benzo[d]imidazole [0724] A mixture of 2-bromo-lH-benzo[d] imidazole (0.400 g, 2.04 mmol), allyl bromide (0.35 mL, 4.08 mmol), 1,4-dioxane (15 mL), and 2 M aqueous sodium hydroxide solution (15 mL, 3.00 mmol) stirred for 2 h at 100 ¡ãC. The reaction mixture was cooled to room temperature and diluted with ethyl acetate (50 mL). The organic phase was separated and washed with brine (30 mL), dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum. The residue was purified via preparative thin layer chromatography (eluting with 20percent ethyl acetate/petroleum ether) to afford 1- allyl-2-bromo-lH-benzo[d]imidazole (0.251 g, 52percent) as a yellow oil. MS (ESI, pos. ion) m/z 237, 239 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; BAIR, Kenneth W.; HERBERTZ, Torsten; KAUFFMAN, Goss Stryker; KAYSER-BRICKER, Katherine J.; LUKE, George P.; MARTIN, Matthew W.; MILLAN, David S.; SCHILLER, Shawn E. R.; TALBOT, Adam C.; WO2015/74064; (2015); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

54624-57-6, A common heterocyclic compound, 54624-57-6, name is 2-Bromobenzimidazole, molecular formula is C7H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Tri-tert-butylphosphine (4.4 mL of 1.0 M in toluene, 1.48 g, 0.05 mmol), palladium acetate (0.4 g, 1.83 mmol) and sodium tert-butoxide (22.8 g, 238 mmol)A solution of 2-bromo-1H-benzimidazole (36.0 g, 183 mmol) and p-methoxybromobenzene (35.0 g, 187 mmol) in degassed toluene (1 L) was added and the mixture was heated under reflux 2 hour.The reaction mixture was cooled to room temperature, diluted with toluene and filtered over EtOAc.The filtrate was diluted with water and extracted with toluene and the organic phases were combined and evaporated in vacuo.The residue was filtered through silica gel and recrystallized.Compound a (44.2 g, yield 80percent) was obtained.

The synthetic route of 54624-57-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Liu Xiqing; Cai Hui; (35 pag.)CN108218787; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

54624-57-6,Some common heterocyclic compound, 54624-57-6, name is 2-Bromobenzimidazole, molecular formula is C7H5BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1) In a 250mL three-necked flask, purged with nitrogen, 0.02mol raw material 2-bromo-1H-benzimidazole, 0.03mol iodobenzene, 0.04mol sodium hydride,0.004mol cuprous iodide and 0.01mol o-phenanthroline dissolved in 100ml 1,3-dimethyl-2-imidazolidinone, the reaction was stirred for 20-30h,After the reaction was completed, water was added and the mixture was extracted with methylene chloride. The organic layer was dried over anhydrous sodium sulfate,A mixture of petroleum ether and ethyl acetate was used as a eluent shower, the volume ratio of petroleum ether to ethyl acetate in the eluent was 1: 100,Purification by column chromatography gave Intermediate M1; HPLC purity 99.5%, yield 75.8%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromobenzimidazole, its application will become more common.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Zhang Zhaochao; Li Chong; (51 pag.)CN107417668; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem