Category: 54147-04-5

Wong, John L.;Fuchs, David S. published 《Reactivities and electronic aspects of nucleic acid heterocycles. III. Hydrolytic behavior of 6-methoxypurines》 in 1974. The article was appeared in 《Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999)》. They have made some progress in their research.Formula: C7H11N3O2 The article mentions the following:

Aqueous acidic hydrolysis of the methoxypurine I (0.1M) gave Me 5-amino-1-methylimidazole-4-carboxylate and 9-methylhypoxanthine (7:3). II and III behaved analogously. At >0.2M concentrations of the methoxypurines, O to N methyl migration became competitive. The hydrolysis proceeded via purine dications. The results indicated that no O-methylated pyrimidines or purines could survive the acidic conditions used prevalently in the chem. hydrolysis of nucleic acids. And Ethyl 5-amino-1-methyl-1H-imidazole-4-carboxylate (cas: 54147-04-5) was used in the research process.

Ethyl 5-amino-1-methyl-1H-imidazole-4-carboxylate (cas: 54147-04-5 Formula: C7H11N3O2) is a synthetic retinoid that has been shown to be effective in the treatment of psoriasis. It inhibits the activation of histone lysine residues and increases the terminal half life of endogenous synthesis.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 54147-04-5《Reductive methylation of N¹-substituted 4-ethoxycarbonyl-5-imidazoles》 was published in 1980. The authors were Alenin, V. V.;Domkin, V. D., and the article was included in《Zhurnal Obshchei Khimii》. The author mentioned the following in the article:

Reductive methylation of I (R¹ = Me, R² = H, R³ = Et) by CH₂O and NaBH₄ gave I (R¹ = R² = Me, R³ = Et) which was hydrolyzed by base to give I (R¹ = R² = Me, R³ = H). Analogously obtained was I (R¹ = 2,3-O-isopropylidene-β-D-ribofuranosyl, R² = Me, R³ = Et) which was phosphorylated and deblocked to give I (R¹ = 5-O-phospho-β-D-ribofuranosyl, R² = Me, R³ = H). And Ethyl 5-amino-1-methyl-1H-imidazole-4-carboxylate (cas: 54147-04-5) was used in the research process.

Ethyl 5-amino-1-methyl-1H-imidazole-4-carboxylate (cas: 54147-04-5 Application of 54147-04-5) is a synthetic retinoid that has been shown to be effective in the treatment of psoriasis. It inhibits the activation of histone lysine residues and increases the terminal half life of endogenous synthesis.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem