Category: 53981-69-4

Synthetic Route of 53981-69-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53981-69-4 name is 1-(1H-Imidazol-2-yl)ethanone, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 6-bromo-3-(bromomethyl)-l,2-benzoxazole (55 mg) in acetonitrile (0.9 mL) were added potassium carbonate (78 mg) and l-(lH-imidazol-2-yl)ethanone (22 mg). After stirring for 2 hours at 80 C, the reaction was filtered and the filtrate was concentrated in vacuo. The residue was purified with OH-type silica gel column chromatography (5-60 % EtOAc in n-hexane) to give the title compound (54 mg, 89 % yield) as colorless solid. MS (ESI) m/z : 320[M+l] RT = 0.936 min. LCMS Condition : B.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(1H-Imidazol-2-yl)ethanone, and friends who are interested can also refer to it.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; TAKASHIMA, Hajime; SASAKI, Toru; TANAKA, Nozomi; OTAKE, Norikazu; TSURUTA, Risa; YAMADA, Yousuke; MATSUDA, Yohei; OGATA, Yuya; (346 pag.)WO2018/216822; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 53981-69-4, name is 1-(1H-Imidazol-2-yl)ethanone, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-(1H-Imidazol-2-yl)ethanone

To a mixture of l-(l /-imidazol-2-yl) ethan-l-one (32 mg, 0.290 mmol) and 2-(4- formylphenyl)-N-(perfluorophenyl) acetamide (124 mg, 0.377 mmol, 1.3 eq) in a microwave vial under nitrogen were added piperidine (61 mu, 0.726 mmol, 2.5 eq) and anhydrous methanol (5.0 mL) via syringe. The reaction mixture was heated in the microwave synthesizer for 5 h and it was monitored by TLC (50% ethyl acetate/hexanes). Methanol was removed on a rotary evaporator to obtain a brown oil. It was chromatographed by preparative TLC in 50-75% ethyl acetate /hexanes to obtain (£)-2-(4-(3-(l /-imidazol-2-yl)-3-oxoprop- l-en-l-yl) phenyl)-N-(perfluorophenyl) acetamide 35 as a brown solid (16 mg, 13.07%). TLC R/ = 0.5 (50% ethyl acetate/hexanes), mp 235 C. NMR (600 MHz, CD3OD) delta 7.94 (s, 1H), 7.92 (s, 2H), 7.89 (s, 2H), 7.86 (s, 1H), 7.75 (d, J = 8.1 Hz, 6H), 7.46 (d, J = 8.0 Hz, 6H), 7.41 (s, 3H), 7.29 (s, 3H), 3.83 (s, 7H). 13C NMR (151 MHz, MeOD) delta 178.61, 170.86, 166.79, 145.98, 140.81, 137.75, 133.73,130.15,129.59,128.66 ,121.42120.82,41.70 ppm. HRMS calcd for C20H14F5N3O2 :423.10 found: 423.1146

The synthetic route of 53981-69-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE UNIVERSITY OF TOLEDO; TILLEKERATNE, Viranga; AL-HAMASHI, Ayad; DLAMINI, Samkeliso; ALQAHTANI, Abdulateef, Saeed; KARAJ, Endri; (69 pag.)WO2019/36607; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 53981-69-4,Some common heterocyclic compound, 53981-69-4, name is 1-(1H-Imidazol-2-yl)ethanone, molecular formula is C5H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 1-(3-bromopropyl)-4-chlorobenzene (1.5 g) and 2-acetylimidazole (0.87 g) in DMF (15 mL) was added potassium carbonate (3.6 g). The mixture was stirred for 1.5 hours at 70 C and allowed to cool to room temperature. The reaction was quenched with water and extracted with EtOAc. The organic layer was washed with brine three times and concentrated in vacuo onto ISOLUTE HM-N. The residue was purified with OH-type silica gel column chromatography (1-20 % MeOH in CHCI3) to give the title compound (Intermediate- 1, 1.6 g, 94 % yield) as light yellow oil. -NMR, MS and LCMS retention time data of Intermediate- 1 are shown in Table 1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(1H-Imidazol-2-yl)ethanone, its application will become more common.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; TAKASHIMA, Hajime; SASAKI, Toru; TANAKA, Nozomi; OTAKE, Norikazu; TSURUTA, Risa; YAMADA, Yousuke; MATSUDA, Yohei; OGATA, Yuya; (346 pag.)WO2018/216822; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 53981-69-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53981-69-4, name is 1-(1H-Imidazol-2-yl)ethanone belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

alpha-Mangostin (1, 205 mg, 0.5 mmol) was dissolved in dichloromethane (10 mL) and acetylimidazole (55 mg, 0.5 mmol) was added at room temperature. After 6 hours, additional acetylimidazole (55 mg, 0.5 mmol) was added and the reaction was allowed to proceed overnight. The mixture was then diluted with ethyl acetate (15 mL) and washed in succession with 1M HCl (2 × 10 mL), saturated sodium hydrogen carbonate (2 × 10 mL) and saturated sodium chloride (2 × 10 mL). The organic layer was dried (sodium sulfate) and the solvent was evaporated under reduced pressure to give a yellow, oily solid (210 mg). Flash-column chromatography of the residue (silica gel, ethyl acetate/hexane 15 : 85) afforded three fractions: 3,6-O-diacetyl–mangostin (4, yellow solid, 20 mg, 8% yield); 3-O-acetyl–mangostin (6, yellow solid, 100 mg, 44% yield); unreacted -mangostin (1, yellow solid, 40 mg, 20 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(1H-Imidazol-2-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Electric Literature of 53981-69-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53981-69-4 name is 1-(1H-Imidazol-2-yl)ethanone, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To an ice coled solution of 1-(1H-imidazol-2-yl)ethanone (2.0 g) in MeOH (36 mL) was added NaBH4 (0.69 g). After stirring for 30 minutes at 0C, the reaction mixture was concentrated in vacuo. The residue was purified with amino-type silica gel column chromatography (0- 10 % MeOH in CHCb) to give the title compound (lntermediate-3, 1.9g, 96 % yield) as colorless solid. -NMR data of Intermediate -3 is shown in Table 1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(1H-Imidazol-2-yl)ethanone, and friends who are interested can also refer to it.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; TAKASHIMA, Hajime; SASAKI, Toru; TANAKA, Nozomi; OTAKE, Norikazu; TSURUTA, Risa; YAMADA, Yousuke; MATSUDA, Yohei; OGATA, Yuya; (346 pag.)WO2018/216822; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem