Category: 53710-78-4

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 53710-78-4

General procedure: 60% NaH (9.6mg, 0.24mmol) was added to a solution of 5a (100mg, 0.24mmol) in dry DMF (10mL) at room temperature. After stirring for 30min, 1-(3-chloropropyl)-1H-imidazole (52mg, 0.36mmol) was added and the mixture was then stirred for 5h at 80C. After cooling, the mixture was poured into cold water (200mL) and extracted with EtOAc (3×50mL). The combined organic phase was washed with brine (3×150mL), dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using dichloromethane/ 20 methanol/triethylamine (120:4:1, v/v/v) as eluent to afford 64.4mg (51.0%) 6a as a red solid.

According to the analysis of related databases, 53710-78-4, the application of this compound in the production field has become more and more popular.

Synthetic Route of 53710-78-4,Some common heterocyclic compound, 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole, molecular formula is C6H9ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 60% NaH (9.6mg, 0.24mmol) was added to a solution of 5a (100mg, 0.24mmol) in dry DMF (10mL) at room temperature. After stirring for 30min, 1-(3-chloropropyl)-1H-imidazole (52mg, 0.36mmol) was added and the mixture was then stirred for 5h at 80C. After cooling, the mixture was poured into cold water (200mL) and extracted with EtOAc (3×50mL). The combined organic phase was washed with brine (3×150mL), dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using dichloromethane/ 20 methanol/triethylamine (120:4:1, v/v/v) as eluent to afford 64.4mg (51.0%) 6a as a red solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(3-Chloropropyl)-1H-imidazole, its application will become more common.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 53710-78-4 as follows. HPLC of Formula: C6H9ClN2

EXAMPLE 23 A mixture of 4-(3′-chloro-4′-fluoroanilino)-6-hydroxy-7-methoxyquinazoline (1.5 g), 3-(imidazol-1-yl)propyl chloride (0.67 g), potassium carbonate (3 g) and DMF (40 ml) was stirred and heated to 90 C. for 1 hour. A second portion (0.12 g) of the propyl chloride was added and the mixture was heated to 90 C. for a further hour. The mixture was cooled to ambient temperature, filtered and evaporated. The residue was purified by column chromatography using a 9:1 mixture of methylene chloride and methanol as eluent. There was thus obtained 4-(3′-chloro-4′-fluoroanilino)-6-(3-imidazol-1 -ylpropoxy)-7-methoxyquinazoline (0.66 g); NMR Spectrum: 2.5 (m, 2H), 4.12 (s, 3H), 4.25 (t, 2H), 4.35 (t, 2H), 7.08 (s, 1H), 7.4 (d, 2H), 7.6 (t, 1H), 7.8 (s, 1H), 7.95 (m, 2H), 8.25 (m, 1H), 8.65 (s, 1H), 9.7 (broad s, 1H); Elemental Analysis: Found C, 58.2; H, 4.6; N, 16.6; C21 H19 ClFN5 O2 0.2H2 O requires C, 58.5; H, 4.5; N, 16.2%.

According to the analysis of related databases, 53710-78-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zeneca Limited; US5770599; (1998); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 53710-78-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 60% NaH (9.6mg, 0.24mmol) was added to a solution of 5a (100mg, 0.24mmol) in dry DMF (10mL) at room temperature. After stirring for 30min, 1-(3-chloropropyl)-1H-imidazole (52mg, 0.36mmol) was added and the mixture was then stirred for 5h at 80C. After cooling, the mixture was poured into cold water (200mL) and extracted with EtOAc (3¡Á50mL). The combined organic phase was washed with brine (3¡Á150mL), dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using dichloromethane/ 20 methanol/triethylamine (120:4:1, v/v/v) as eluent to afford 64.4mg (51.0%) 6a as a red solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(3-Chloropropyl)-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Liu, Xiaoqi; Hu, Yuanyuan; Gao, Anhui; Xu, Meng; Gao, Lixin; Xu, Lei; Zhou, Yubo; Gao, Jianrong; Ye, Qing; Li, Jia; Bioorganic and Medicinal Chemistry; vol. 27; 4; (2019); p. 589 – 603;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 53710-78-4, The chemical industry reduces the impact on the environment during synthesis 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole, I believe this compound will play a more active role in future production and life.

General procedure: 60% NaH (9.6mg, 0.24mmol) was added to a solution of 5a (100mg, 0.24mmol) in dry DMF (10mL) at room temperature. After stirring for 30min, 1-(3-chloropropyl)-1H-imidazole (52mg, 0.36mmol) was added and the mixture was then stirred for 5h at 80C. After cooling, the mixture was poured into cold water (200mL) and extracted with EtOAc (3¡Á50mL). The combined organic phase was washed with brine (3¡Á150mL), dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using dichloromethane/ 20 methanol/triethylamine (120:4:1, v/v/v) as eluent to afford 64.4mg (51.0%) 6a as a red solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(3-Chloropropyl)-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Liu, Xiaoqi; Hu, Yuanyuan; Gao, Anhui; Xu, Meng; Gao, Lixin; Xu, Lei; Zhou, Yubo; Gao, Jianrong; Ye, Qing; Li, Jia; Bioorganic and Medicinal Chemistry; vol. 27; 4; (2019); p. 589 – 603;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 53710-78-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Under ice-cooling, 1-(3-chloropropyl)-1H-imidazole (1.90 g, 13.14 mmol), cesium carbonate (4.28 g, 13.14 mmol) and a catalytic amount of potassium iodide were dissolved in DMF (30 mL).2-Fluoro-4-nitroaniline (1.38 g, 8.84 mmol) was added in one portion and the reaction was heated to reflux for 36 h.After the reaction was completed, the mixture was cooled to room temperature, filtered, and the solvent was evaporated under reduced pressure. The residue was added to water (50 mL) and extracted with dichloromethane (20 mL ¡Á 2).The organic phase was washed with saturated brine (20 mL¡Á2), the solvent was evaporated under reduced pressure, and the crude product was purified by column chromatography (dichloromethane/methanol (V/V)=15/1).A yellow oil (2.85 g, 82%) was obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(3-Chloropropyl)-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, YINGJUN; ZHANG, JIANCUN; WANG, XIAOJUN; LIN, RUNFENG; CAO, SHENGTIAN; WANG, ZHAOHE; LI, JING; (226 pag.)TWI607995; (2017); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 1-(3-Chloropropyl)-1H-imidazole

Sodium hydride (15 mg, 0.37 mmol) was added to a solution ofcompound 31 (90 mg, 0.31 mmol) in dry 10 mL DMF at 0 C, after 0.5 h,1-(3-chloropropyl)-1H-imidazole (66 mg, 0.47 mmol) was added. Theresultant solution was heated at 65 C for 10 h. After cooling, the solutionwas poured into H2O (50 mL) and then extracted with EtOAc.The organic extracts were washed with brine and dried over Na2SO4.After removal of the solvent, the remaining solid was chromatographedon a silica gel column using CH2Cl2/MeOH (15:1) as eluent to afford asa yellow solid (0.97 g, 78%), mp: 164-166 C. 1H NMR (500 MHz,DMSO-d6) delta 8.76 (s, 1H), 8.59 (s, 1H), 8.38 (s, 1H), 8.16 (d, J=5.2 Hz,1H), 7.65 (s, 1H), 7.55 (d, J=8.5 Hz, 1H), 7.48 (s, 1H), 7.26 (d,J=8.2 Hz, 1H), 7.03 (d, J=5.3 Hz, 1H), 6.86 (s, 2H), 5.43 (s, 1H),4.30 (t, J=6.5 Hz, 2H), 4.22 (t, J=6.5 Hz, 2H), 2.42 (m, 2H), 1.51 (s,6H). HRMS m/z (ESI+): Calculated for C23H24N6OH+ ([M+H]+):401.2090. Found 401.2093

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Ye, Qing; Li, Qiu; Gao, Anhui; Ying, Huazhou; Cheng, Gang; Chen, Jing; Che, Jinxin; Li, Jia; Dong, Xiaowu; Zhou, Yubo; Chemical Physics Letters; vol. 718; (2019); p. 38 – 45;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C6H9ClN2

General procedure: To a 25mL flask was added 6-bromo-2H-benzo[b][1,4]oxazin-3(4H)-one (0.46 g, 2mmol), 4-(2-chloroethyl)morpholine (0.30 g, 2mmol), potassiumcarbonate (0.42 g, 3mmol) and DMF (8 mL), the reaction mixturewas heated at 60 C and stirred for 6 h. After the reaction was completed,the DMF was removed at reduced pressure and the residue was purified onsilica gel with chloroform/methanol (V:V 100:1) to give the title compoundas awhite powder. Yield 94.1%, m.p. 80-82 C. 1H NMR (600MHz,DMSO-d6) delta 7.51 (d, J=2.2 Hz, 1H, Ar-H), 7.17 (dd, J=8.5, 2.2Hz, 1H,Ar-H), 6.97 (d, J=8.5 Hz, 1H, Ar-H), 4.65 (s, 2H, Ar-H), 4.02 (t,J=6.4Hz, 2H, CH2), 3.53 (s, 4H, CH2¡Á2), 2.47 (t, J=6.4 Hz, 2H, CH2),2.43 (s, 4H, CH2¡Á2). ESI-MS: m/z 341.0 [M+H]+.Compounds 2b-j were synthesized according to the procedure describedin 2a.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 53710-78-4.

Reference:
Article; Dong, Fu-Dan; Liu, Dan-Dan; Deng, Cheng-Long; Qin, Xiao-chun; Chen, Kai; Wang, Jian; Song, Hong-Rui; Ding, Huai-Wei; Bioorganic and Medicinal Chemistry; vol. 26; 14; (2018); p. 3982 – 3991;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem